Publications:

Teichweyde N, Horn PA, and Klump H (2017) HOXB4 increases Runx1 expression to promote the de novo formation of Multipotent Hematopoietic Cells. Transfus Med Hemother 44, 128-134. DOI: 10.1159/000477130

Steens J, Zuk M, Benchellal M, Bornemann L, Teichweyde N, Hess J, Unger K, Görgens A, Klump H and Klein D (2017) In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells. Stem Cell Reports 8, 919-932.

Stanurova J, Neureiter A, Hiber M, de Oliveira Kessler H, Stolp K, Goetzke R, Klein D, Bankfalvi A, Klump H and Steenpass L (2016) Angelman Syndrome-derived neurons display late onset of paternal UBE3A silencing. Sci Rep 6, 30792.

von Wnuck Lipinski K, Sattler K, Peters S, Weske S, Keul P, Klump H, Heusch G, Göthert JR and Levkau B (2016) Hepatocyte Nuclear Factor 1A is a cell intrinsic transcription factor required for B cell differentiation and development in mice. J Immunol 196, 1655-1665.

Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, Duyvene de Wit T, Eichinger S, Fibbe W, Green T, de Haas F, Iolascon A, Jaffredo T, Rodeghiero F, Salles G, Schuringa JJ (2016) The European Hematology Association Roadmap for European Hematology Research: a consensus document.
section 1.9. Kouskoff V, Forrester L, Graf T, Klump H, Lacaud G, Menendez P, Mountford J. Reprogramming/induced pluripotent stem cells/embryonic stem cells. Haematologica 101, 115-208.

Pilat S, Carotta S, and Klump H (2013) Development of Hematopoietic Stem and Progenitor Cells from Mouse Embryonic Stem Cells, in vitro, Supported by Ectopic HOXB4 Expression. Methods Mol Biol 1029, 129-147.

Klump H, Teichweyde N, Meyer C, and Horn PA (2013) Development of patient-specific hematopoietic stem- and progenitor cell grafts from pluripotent stem cells, in vitro. Curr Mol Med 13, 815-820.

Lesinski DA, Heinz N, Pilat S, Rudolph C, Jacobs R, Schlegelberger B, Klump H, Schiedlmeier B. (2012) Serum- and stromal cell-free generation of embryonic stem cell-derived hematopoietic cells, in vitro, capable of multilineage repopulation of immunocompetent mice.  Stem Cells Transl Med 1, 581-591.

Warlich E, Kühle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Schöler HR, Baum, C, Schroeder T, Schambach A. (2011) Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming. Mol Ther 19, 782-9.

Chan KM, Bonde S, Klump H, Zavazava N. (2008) Hematopoiesis and immunity of HOXB4 transduced embryonic stem cell-derived hematopoietic progenitor cells. Blood 111, 2953-61.

Schiedlmeier B, Santos AC, Ribeiro A, Moncaut N, Lesinski D, Auer H, Kornacker K, Ostertag W, Baum C, Mallo M, Klump H. (2007) HOXB4´s road map to stem cell expansion. Proc Natl Acad Sci USA 104, 16952-57.

Will E, Speidel D, Wang Z, Ghiaur G, Rimek A, Schiedlmeier B, Ostertag W, Baum C, Klump H. (2006) HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle 5, 14-22.

Pilat S, Carotta S, Schiedlmeier B, Kamino K, Mairhofer A, Will E, Modlich U, Beug H, Ostertag W, Steinlein P, Baum C, Klump H. (2005) HOXB4 Enforces Equivalent Fates of ES-Cell Derived and Adult Hematopoietic Cells. Proc Natl Acad Sci USA 102, 12101-06.

Klump H, Schiedlmeier B, Baum C. Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold. (2005) Annals NY Acad Sci 1044, 1-10.

Kraunus J, Schaumann DHS, Meyer J, Modlich U, Fehse B, Brandenburg G, von Laer D, Klump H, Schambach A, Bohne J, Baum C. (2004) Self-inactivating retroviral vectors with improved RNA processing. Gene Therapy 11, 1568-78.

Warncke M, Vogt B, Ulrich J, von Laer MD, Beyer W, Klump H, Micheel B, and Sheriff A (2004) Efficient in vitro transduction of naive murine B cells with lentiviral vectors. Biochem Biophys Res Commun 318, 673-679.

Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag,W. (2003) High level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage to human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Blood 101, 1759-68.

Will E, Klump H, Heffner N, Schwieger M, Schiedlmeier B, Ostertag W, Baum C, Stocking C (2002) Unmodified Cre recombinase crosses the membrane. Nucl Acids Res 30, e59.

Klump H, Schiedlmeier B, Vogt B, Ryan M, Ostertag W, Baum C (2001) Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy. Gene Therapy 8, 811-17.

Fehse B, Richters A, Putimtseva-Scharf O, Klump H, Li Z, Ostertag W, Zander AR, and Baum C (2000) CD34 splice variant: an attractive marker for selection of gene-modified cells. Molecular Therapy 1, 448-456.

Klump H, Auer H, Liebig HD, Kuechler E, and Skern T (1997) Proteolytically active 2A proteinase of human rhinovirus 2 is toxic for Saccharomyces cerevisiae but does not cleave the homologues of eIF-4 gamma in vivo or in vitro. Virology 220, 109-118.

Sommergruber W, Ahorn H, Klump H, Seipelt J, Zoephel A, Fessl F, Krystek E, Blaas D, Kuechler E, Liebig HD, and Skern T (1994) 2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif. Virology 198, 741-745.

Lamphear BJ, Yan R, Yang F, Waters D, Liebig HD, Klump H, Kuechler E, Skern T, and Rhoads RE (1993) Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus. J Biol Chem 268, 19200-192003.

Liebig HD, Ziegler E, Yan R, Hartmuth K, Klump H, Kowalski H, Blaas D, Sommergruber W, Frasel L, Lamphear B, Rhoads RE, Kuechler E, and Skern T (1993) Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation. Biochemistry 32, 7581-7588.