Publikationen (alle)
- Pellegrini, M., Calzascia, T., Toe, J.G., Preston, S.P., Lin, A.E., Elford, A.R., Shahinian, A., Lang, P.A., Lang, K.S., Morre, M., Assouline, B., Lahl, K., Sparwasser, T., Tedder, T.F., Paik, J.H., Depinho, R.A., Basta, S., Ohashi, P.S. & Mak, T.W. IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology. Cell Feb 2. [Epub ahead of print](2011).
- Navarini, A.A., Krzyzowska, M., Lang, K.S., Horvath, E., Hengartner, H., Niemialtowski, M.G. & Zinkernagel, R.M. Long-lasting immunity by early infection of maternal-antibody-protected infants. Eur J Immunol 40, 113-116 (2010).
- Lang, P.A., Recher, M., Honke, N., Scheu, S., Borkens, S., Gailus, N., Krings, C., Meryk, A., Kulawik, A., Cervantes-Barragan, L., Van Rooijen, N., Kalinke, U., Ludewig, B., Hengartner, H., Harris, N., Haussinger, D., Ohashi, P.S., Zinkernagel, R.M. & Lang, K.S. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 52, 25-32 (2010).
- Lang, P.A., Merkler, D., Funkner, P., Shaabani, N., Meryk, A., Krings, C., Barthuber, C., Recher, M., Bruck, W., Haussinger, D., Ohashi, P.S. & Lang, K.S. Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur J Immunol 40, 2401-2408 (2010).
- Gibbert, K., Dietze, K.K., Zelinskyy, G., Lang, K.S., Barchet, W., Kirschning, C.J. & Dittmer, U. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol 185, 6179-6189 (2010).
- Contaldo, C., Lindenblatt, N., Elsherbiny, A., Hogger, D.C., Borozadi, M.K., Vetter, S.T., Lang, K.S., Handschin, A.E. & Giovanoli, P. EPO REQUIRES ENOS TO COUNTERACT TNF-alpha INDUCED MICROCIRCULATORY DYSFUNCTION IN MURINE STRIATED MUSCLE. Shock (2010).
- Navarini, A.A., *Lang, K.S., Verschoor, A., Recher, M., Zinkernagel, A.S., Nizet, V., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci U S A 106, 7107-7112 (2009).
- Lang, P.A., Kasinathan, R.S., Brand, V.B., Duranton, C., Lang, C., Koka, S., Shumilina, E., Kempe, D.S., Tanneur, V., Akel, A., Lang, K.S., Foller, M., Kun, J.F., Kremsner, P.G., Wesselborg, S., Laufer, S., Clemen, C.S., Herr, C., Noegel, A.A., Wieder, T., Gulbins, E., Lang, F. & Huber, S.M. Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cell Physiol Biochem 24, 415-428 (2009).
- Lang, P.A., Cervantes-Barragan, L., Verschoor, A., Navarini, A.A., Recher, M., Pellegrini, M., Flatz, L., Bergthaler, A., Honda, K., Ludewig, B., Ohashi, P.S. & Lang, K.S. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 113, 1045-1052 (2009).
- Joly, S., Francke, M., Ulbricht, E., Beck, S., Seeliger, M., Hirrlinger, P., Hirrlinger, J., Lang, K.S., Zinkernagel, M., Odermatt, B., Samardzija, M., Reichenbach, A., Grimm, C. & Reme, C.E. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol 174, 2310-2323 (2009).
- Cervantes-Barragan, L., Gil-Cruz, C., Pastelin-Palacios, R., Lang, K.S., Isibasi, A., Ludewig, B. & Lopez-Macias, C. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 39, 126-135 (2009).
- Wang, K., Mahmud, H., Foller, M., Biswas, R., Lang, K.S., Bohn, E., Gotz, F. & Lang, F. Lipopeptides in the triggering of erythrocyte cell membrane scrambling. Cell Physiol Biochem 22, 381-386 (2008).
- Lohning, M., Hegazy, A.N., Pinschewer, D.D., Busse, D., Lang, K.S., Hofer, T., Radbruch, A., Zinkernagel, R.M. & Hengartner, H. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med 205, 53-61 (2008).
- Lang, P.A., Contaldo, C., Georgiev, P., El-Badry, A.M., Recher, M., Kurrer, M., Cervantes-Barragan, L., Ludewig, B., Calzascia, T., Bolinger, B., Merkler, D., Odermatt, B., Bader, M., Graf, R., Clavien, P.A., Hegazy, A.N., Lohning, M., Harris, N.L., Ohashi, P.S., Hengartner, H., Zinkernagel, R.M. & *Lang, K.S. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 14, 756-761 (2008).
- Johansen, P., Storni, T., Rettig, L., Qiu, Z., Der-Sarkissian, A., Smith, K.A., Manolova, V., Lang, K.S., Senti, G., Mullhaupt, B., Gerlach, T., Speck, R.F., Bot, A. & Kundig, T.M. Antigen kinetics determines immune reactivity. Proc Natl Acad Sci U S A 105, 5189-5194 (2008).
- Ittner, L.M., Schwerdtfeger, K., Kunz, T.H., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K.S., Kurrer, M.O., Gotz, J., Born, W. & Fischer, J.A. Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clin Sci (Lond) 114, 49-58 (2008).
- Heikenwalder, M., Prinz, M., Zeller, N., Lang, K.S., Junt, T., Rossi, S., Tumanov, A., Schmidt, H., Priller, J., Flatz, L., Rulicke, T., Macpherson, A.J., Hollander, G.A., Nedospasov, S.A. & Aguzzi, A. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol 172, 1555-1570 (2008).
- Falk, S., Wurdak, H., Ittner, L.M., Ille, F., Sumara, G., Schmid, M.T., Draganova, K., Lang, K.S., Paratore, C., Leveen, P., Suter, U., Karlsson, S., Born, W., Ricci, R., Gotz, M. & Sommer, L. Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell 2, 472-483 (2008).
- Recher, M., *Lang, K.S., Navarini, A., Hunziker, L., Lang, P.A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A.N., Eschli, B., Theocharides, A., Jeker, L.T., Merkler, D., Odermatt, B., Hersberger, M., Hengartner, H. & Zinkernagel, R.M. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med 13, 1316-1323 (2007).
- Lotscher, M., Recher, M., Lang, K.S., Navarini, A., Hunziker, L., Santimaria, R., Glatzel, M., Schwarz, P., Boni, J. & Zinkernagel, R.M. Induced prion protein controls immune-activated retroviruses in the mouse spleen. PLoS ONE 2, e1158 (2007).
- Lang, K.S., Navarini, A.A., Recher, M., Lang, P.A., Heikenwalder, M., Stecher, B., Bergthaler, A., Odermatt, B., Akira, S., Honda, K., Hengartner, H. & Zinkernagel, R.M. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. Eur J Immunol 37, 2434-2440 (2007).
- Lang, K.S., Hegazy, A.N., Lang, P.A., Eschli, B., Lohning, M., Hengartner, H., Zinkernagel, R.M. & Recher, M. "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses. PLoS ONE 2, e1162 (2007).
- Georgiev, P., Navarini, A.A., Eloranta, J.J., Lang, K.S., Kullak-Ublick, G.A., Nocito, A., Dahm, F., Jochum, W., Graf, R. & Clavien, P.A. Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse. Gut 56, 121-128 (2007).
- Eschli, B., Zellweger, R.M., Wepf, A., Lang, K.S., Quirin, K., Weber, J., Zinkernagel, R.M. & Hengartner, H. Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus. J Virol 81, 11650-11657 (2007).
- Cervantes-Barragan, L., Zust, R., Weber, F., Spiegel, M., Lang, K.S., Akira, S., Thiel, V. & Ludewig, B. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109, 1131-1137 (2007).
- Navarini, A.A., Recher, M., Lang, K.S., Georgiev, P., Meury, S., Bergthaler, A., Flatz, L., Bille, J., Landmann, R., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci U S A 103, 15535-15539 (2006).
- Kempe, D.S., Lang, P.A., Duranton, C., Akel, A., Lang, K.S., Huber, S.M., Wieder, T. & Lang, F. Enhanced programmed cell death of iron-deficient erythrocytes. FASEB J 20, 368-370 (2006).
- Fink, K., Lang, K.S., Manjarrez-Orduno, N., Junt, T., Senn, B.M., Holdener, M., Akira, S., Zinkernagel, R.M. & Hengartner, H. Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur J Immunol 36, 2094-2105 (2006).
- Dahm, F., Nocito, A., Bielawska, A., Lang, K.S., Georgiev, P., Asmis, L.M., Bielawski, J., Madon, J., Hannun, Y.A. & Clavien, P.A. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost 4, 2704-2709 (2006).
- *Lang, K.S., Georgiev, P., Recher, M., Navarini, A.A., Bergthaler, A., Heikenwalder, M., Harris, N.L., Junt, T., Odermatt, B., Clavien, P.A., Pircher, H., Akira, S., Hengartner, H. & Zinkernagel, R.M. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. J Clin Invest 116, 2456-2463 (2006).
- Wurdak, H., Ittner, L.M., Lang, K.S., Leveen, P., Suter, U., Fischer, J.A., Karlsson, S., Born, W. & Sommer, L. Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 19, 530-535 (2005).
- Lang, K.S., Recher, M., Navarini, A.A., Freigang, S., Harris, N.L., van den Broek, M., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology. J Immunol 175, 5524-5531 (2005).
- *Lang, K.S., Recher, M., Navarini, A.A., Harris, N.L., Lohning, M., Junt, T., Probst, H.C., Hengartner, H. & Zinkernagel, R.M. Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol 35, 738-745 (2005).
- *Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H. & Zinkernagel, R.M. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 11, 138-145 (2005).
- Recher, M., *Lang, K.S., Hunziker, L., Freigang, S., Eschli, B., Harris, N.L., Navarini, A., Senn, B.M., Fink, K., Lotscher, M., Hangartner, L., Zellweger, R., Hersberger, M., Theocharides, A., Hengartner, H. & Zinkernagel, R.M. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol 5, 934-942 (2004).
- Lang, K.S., Myssina, S., Lang, P.A., Tanneur, V., Kempe, D.S., Mack, A.F., Huber, S.M., Wieder, T., Lang, F. & Duranton, C. Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl. Am J Physiol Renal Physiol 286, F1046-1053 (2004).
- Lang, K.S., Myssina, S., Brand, V., Sandu, C., Lang, P.A., Berchtold, S., Huber, S.M., Lang, F. & Wieder, T. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ 11, 231-243 (2004).
- Huber, S.M., Duranton, C., Henke, G., Van De Sand, C., Heussler, V., Shumilina, E., Sandu, C.D., Tanneur, V., Brand, V., Kasinathan, R.S., Lang, K.S., Kremsner, P.G., Hubner, C.A., Rust, M.B., Dedek, K., Jentsch, T.J. & Lang, F. Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte. J Biol Chem 279, 41444-41452 (2004).
- Grau, R., Lang, K.S., Wernet, D., Lang, P., Niethammer, D., Pusch, C.M. & Handgretinger, R. Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hematopoietic stem cells in healthy individuals. Exp Mol Pathol 76, 90-98 (2004).
- Myssina, S., Huber, S.M., Birka, C., Lang, P.A., Lang, K.S., Friedrich, B., Risler, T., Wieder, T. & Lang, F. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol 14, 2750-2757 (2003).
- Lang, K.S., Weigert, C., Braedel, S., Fillon, S., Palmada, M., Schleicher, E., Rammensee, H.G. & Lang, F. Inhibition of interferon-gamma expression by osmotic shrinkage of peripheral blood lymphocytes. Am J Physiol Cell Physiol 284, C200-208 (2003).
- Lang, K.S., Myssina, S., Tanneur, V., Wieder, T., Huber, S.M., Lang, F. & Duranton, C. Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn Schmiedebergs Arch Pharmacol 367, 391-396 (2003).
- Lang, K.S., Mueller, M.M., Tanneur, V., Wallisch, S., Fedorenko, O., Palmada, M., Lang, F., Broer, S., Heilig, C.W., Schleicher, E. & Weigert, C. Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1. Kidney Int 64, 1338-1347 (2003).
- Lang, K.S., Duranton, C., Poehlmann, H., Myssina, S., Bauer, C., Lang, F., Wieder, T. & Huber, S.M. Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ 10, 249-256 (2003).
- Lang, K., Wagner, C., Haddad, G., Burnekova, O. & Geibel, J. Intracellular pH activates membrane-bound Na(+)/H(+) exchanger and vacuolar H(+)-ATPase in human embryonic kidney (HEK) cells. Cell Physiol Biochem 13, 257-262 (2003).
- Lampert, A., Muller, M.M., Berchtold, S., Lang, K.S., Palmada, M., Dobrovinskaya, O. & Lang, F. Effect of dexamethasone on voltage-gated K+ channels in Jurkat T-lymphocytes. Pflugers Arch 447, 168-174 (2003).
- Duranton, C., Huber, S., Tanneur, V., Lang, K., Brand, V., Sandu, C. & Lang, F. Electrophysiological properties of the Plasmodium Falciparum-induced cation conductance of human erythrocytes. Cell Physiol Biochem 13, 189-198 (2003).
- Brand, V.B., Sandu, C.D., Duranton, C., Tanneur, V., Lang, K.S., Huber, S.M. & Lang, F. Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. Cell Physiol Biochem 13, 347-356 (2003).
- Lang, K.S., Roll, B., Myssina, S., Schittenhelm, M., Scheel-Walter, H.G., Kanz, L., Fritz, J., Lang, F., Huber, S.M. & Wieder, T. Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem 12, 365-372 (2002).
- Lang, K.S., Moris, A., Gouttefangeas, C., Walter, S., Teichgraber, V., Miller, M., Wernet, D., Hamprecht, K., Rammensee, H.G. & Stevanovic, S. High frequency of human cytomegalovirus (HCMV)-specific CD8+ T cells detected in a healthy CMV-seropositive donor. Cell Mol Life Sci 59, 1076-1080 (2002).
- Lang, K.S., Fillon, S., Schneider, D., Rammensee, H.G. & Lang, F. Stimulation of TNF alpha expression by hyperosmotic stress. Pflugers Arch 443, 798-803 (2002).
- Lang, K.S., Caroli, C.C., Muhm, A., Wernet, D., Moris, A., Schittek, B., Knauss-Scherwitz, E., Stevanovic, S., Rammensee, H.G. & Garbe, C. HLA-A2 restricted, melanocyte-specific CD8(+) T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA/MART1. J Invest Dermatol 116, 891-897 (2001).
- Lang, F., Madlung, J., Bock, J., Lukewille, U., Kaltenbach, S., Lang, K.S., Belka, C., Wagner, C.A., Lang, H.J., Gulbins, E. & Lepple-Wienhues, A. Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation. Pflugers Arch 440, 902-907 (2000).
Übersichtsarbeiten in Zeitschriften
- Lang, P.A., Recher, M., Haussinger, D. & Lang, K.S. Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. Cell Physiol Biochem 26, 263-272 (2010).
- Lang, K.S. Host mechanisms in viral hepatitis. Dig Dis 28, 25-30 (2010).
- Lang, K.S., Burow, A., Kurrer, M., Lang, P.A. & Recher, M. The role of the innate immune response in autoimmune disease. J Autoimmun 29, 206-212 (2007).
- Lang, F., Foller, M., Lang, K., Lang, P., Ritter, M., Vereninov, A., Szabo, I., Huber, S.M. & Gulbins, E. Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol 428, 209-225 (2007).
- Recher, M. & Lang, K.S. Innate (over)immunity and adaptive autoimmune disease. Curr Top Microbiol Immunol 305, 89-104 (2006).
- Lang, F., Lang, K.S., Lang, P.A., Huber, S.M. & Wieder, T. Osmotic shock-induced suicidal death of erythrocytes. Acta Physiol (Oxf) 187, 191-198 (2006).
- Lang, F., Lang, K.S., Lang, P.A., Huber, S.M. & Wieder, T. Mechanisms and significance of eryptosis. Antioxid Redox Signal 8, 1183-1192 (2006).
- Lang, K.S., Lang, P.A., Bauer, C., Duranton, C., Wieder, T., Huber, S.M. & Lang, F. Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem 15, 195-202 (2005).
- Lang, F., Foller, M., Lang, K.S., Lang, P.A., Ritter, M., Gulbins, E., Vereninov, A. & Huber, S.M. Ion channels in cell proliferation and apoptotic cell death. J Membr Biol 205, 147-157 (2005).
- Recher, M., Hunziker, L., Ciurea, A., Harris, N. & Lang, K.S. Public, private and non-specific antibodies induced by non-cytopathic viral infections. Curr Opin Microbiol 7, 426-433 (2004).
- Lang, F., Lang, P.A., Lang, K.S., Brand, V., Tanneur, V., Duranton, C., Wieder, T. & Huber, S.M. Channel-induced apoptosis of infected host cells-the case of malaria. Pflugers Arch 448, 319-324 (2004).
- Lang, F., Gulbins, E., Szabo, I., Lepple-Wienhues, A., Huber, S.M., Duranton, C., Lang, K.S., Lang, P.A. & Wieder, T. Cell volume and the regulation of apoptotic cell death. J Mol Recognit 17, 473-480 (2004).
- Lang, F., Birka, C., Myssina, S., Lang, K.S., Lang, P.A., Tanneur, V., Duranton, C., Wieder, T. & Huber, S.M. Erythrocyte ion channels in regulation of apoptosis. Adv Exp Med Biol 559, 211-217 (2004).
- Lang, F., Lang, K.S., Wieder, T., Myssina, S., Birka, C., Lang, P.A., Kaiser, S., Kempe, D., Duranton, C. & Huber, S.M. Cation channels, cell volume and the death of an erythrocyte. Pflugers Arch 447, 121-125 (2003).