ORIGINAL ARTIKEL

 

1        Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun. 2015 Nov 7. pii: S0896-8411(15)30049-4.

 

2        Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA. Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.

 

3        Honke N, Shaabani N, Merches K, Gassa A, Kraft A, Ehrhardt K, Häussinger D, Löhning M, Dittmer U, Hengel H, Recher M, Lang PA, Lang KS. Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses. Eur J Immunol. 2015 Oct 28. doi: 10.1002/eji.201545765.

 

4        Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing. PLoS Pathog. 2015 Oct 20;11(10):e1005224.

 

5        Brüstle A, Brenner D, Knobbe-Thomsen CB, Cox M, Lang PA, Lang KS, Mak TW. MALT1 is an intrinsic regulator of regulatory T cells. Cell Death Differ. 2015 Sep 25.

 

6         Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget. 2015 Sep 29;6(29):26909-21.

 

7         Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cell Physiol Biochem. 2015;36(6):2379-92.

 

8        Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS. IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus. J Autoimmun. 2015 Aug;62:11-21.

 

9        Warsi J, Hosseinzadeh Z, Elvira B, Pelzl L, Shumilina E, Zhang DE, Lang KS, Lang PA, Lang F. USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2. PLoS One. 2015 Jun 5;10(6):e0129365.

 

10      Wu W, Dietze KK, Gibbert K, Lang KS, Trilling M, Yan H, Wu J, Yang D, Lu M, Roggendorf M, Dittmer U, Liu J. TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell response during an acute retrovirus infection. Sci Rep. 2015 May 21;5:10501.

 

11     Kubagawa H, Carroll MC, Jacob CO, Lang KS, Lee KH, Mak T, McAndrews M, Morse HC 3rd, Nolan GP, Ohno H, Richter GH, Seal R, Wang JY, Wiestner A, Coligan JE. Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. J Immunol. 2015 May 1;194(9):4055-7.

 

12     Qvartskhava N, Lang PA, Görg B, Pozdeev VI, Ortiz MP, Lang KS, Bidmon HJ, Lang E, Leibrock CB, Herebian D, Bode JG, Lang F, Häussinger D.  Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5521-6.

 

13       Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, Pozdeev V, Xu HC, Seifert M, Sharma P, Baldin F, Marquardsen F, Kirschning C, Merches K, Westendorf AM, Häussinger D, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA and Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nature commun. 2015 Feb 18;6:6217.

 

14       Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häusinger D, Recher M, Lang KS, Lang PA. BAFFR deficiency results in limited CD169+ macrophage function during viral infection. J Virol. 2015 Feb 11.

 

15     Göbel C, Breitenbuecher F, Kalkavan H, Hähnel PS, Kasper S, Hoffarth S, Merches K, Schild H, Lang KS, Schuler M. Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. Cell Death Dis. 2014 Dec 11;5:e1568.

 

16      McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA. T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. Eur J Immunol. 2015 Feb;45(2):418-27.

 

17      Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 2015 Jan;22(1):164-73.

 

18      Joedicke JJ, Myers L, Carmody AB, Messer RJ, Wajant H, Lang KS, Lang PA, Mak TW, Hasenkrug KJ, Dittmer U. Activated CD8+ T cells induce expansion of Vb5+ regulatory T cells via TNFR2 signaling. J Immunol. 2014 Sep 15;193(6):2952-60.

 

19      Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology. 2015 Jan;61(1):275-84.

 

20     Pandyra A, Mullen PJ, Kalkat M, Yu R, Pong JT, Li Z, Trudel S, Lang KS, Minden MD, Schimmer AD, Penn LZ. Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop. Cancer Res. 2014 Sep 1;74(17):4772-82 

 

21     Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rhabar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA (2014) Type I interferon protects anti-viral CD8⁺ T cells from NK cell cytotoxicity. Immunity 2014 Jun 19;40(6):949-60. 

 

22     Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR,Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV. Cell Death Differ. 2014 Feb 14.

 

23     Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW. Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5.

 

24     Honke N, Shaabani N, Zhang DE, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M, Lang PA, Lang KS. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog. 2013 Oct;9(10):e1003650. doi: 10.1371/journal.ppat.1003650. Epub 2013 Oct 24.

 

25     Lang KS, Lang PA, Meryk A, Pandyra AA, Merches K, Lee KH, Mak TW. Reply to Honjo et al.: Functional relevant expression of Toso on granulocytes. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2542-3. No abstract available.

 

26     Crome SQ, Lang PA, Lang KS, Ohashi PS. Natural killer cells regulate diverse T cell responses. Trends Immunol. 2013 Jul;34(7):342-9. doi: 10.1016/j.it.2013.03.002. Epub 2013 Apr 17.

 

27     Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW. Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8. doi: 10.1073/pnas.1222264110. Epub 2013 Jan 28.

 

28      Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS. Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J Allergy Clin Immunol. 2013 Mar;131(3):815-24. doi: 10.1016/j.jaci.2012.08.050. Epub 2012 Nov 6.

 

29     Gibbert K, Joedicke JJ, Meryk A, Trilling M, Francois S, Duppach J, Kraft A, Lang KS, Dittmer U. Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection. PLoS Pathog. 2012;8(8):e1002868. doi: 10.1371/journal.ppat.1002868. Epub 2012 Aug 9.

 

30     Chen G, Dimitriou I, Milne L, Lang KS, Lang PA, Fine N, Ohashi PS, Kubes P, Rottapel R. The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. J Immunol. 2012 Sep 1;189(5):2138-50. doi: 10.4049/jimmunol.1103184. Epub 2012 Jul 18.

 

31     Kaesler S, Sobiesiak M, Kneilling M, Volz T, Kempf WE, Lang PA, Lang KS, Wieder T, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Biedermann T. Effective T-cell recall responses require the taurine transporter Taut. Eur J Immunol. 2012 Apr;42(4):831-41. doi: 10.1002/eji.201141690.

 

32     Shaabani N, Honke N, Lang PA, Görg B, Proksch P, Gailus N, Gotoh T, Häussinger D, Lang KS. Tunicamycin inhibits diabetes. Cell Physiol Biochem. 2012;29(3-4):595-602. doi: 10.1159/000338513. Epub 2012 Apr 3.

 

33     Nguyen XH, Fattakhova G, Lang PA, Lang KS, Adam D, Föger N, Lee KH. Antiapoptotic function of Toso (Faim3) in death receptor signaling. Blood. 2012 Feb 16;119(7):1790-1. No abstract available. 

 

34     Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1.

 

35     McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448.

 

36     Lang PA, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1210-5. doi: 10.1073/pnas.1118834109. Epub 2011 Dec 

 

37      Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol. 2011 Nov 20;13(1):51-7. doi: 10.1038/ni.2169.

 

38     Nguyen XH, Lang PA, Lang KS, Adam D, Fattakhova G, Föger N, Kamal MA, Prilla P, Mathieu S, Wagner C, Mak T, Chan AC, Lee KH. Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 2011 Jul 21;118(3):598-608. doi: 10.1182/blood-2010-10-313643. Epub 2011 May 25.

 

39     Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG. Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3. J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17.

 

40     Pellegrini, M., Calzascia, T., Toe, J.G., Preston, S.P., Lin, A.E., Elford, A.R., Shahinian, A., Lang, P.A., Lang, K.S., Morre, M., Assouline, B., Lahl, K., Sparwasser, T., Tedder, T.F., Paik, J.H., Depinho, R.A., Basta, S., Ohashi, P.S. & Mak, T.W. IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology. Cell Feb 2. [Epub ahead of print](2011).

 

41     Navarini, A.A., Krzyzowska, M., Lang, K.S., Horvath, E., Hengartner, H., Niemialtowski, M.G. & Zinkernagel, R.M. Long-lasting immunity by early infection of maternal-antibody-protected infants. Eur J Immunol 40, 113-116 (2010).

 

42     Lang, P.A., Recher, M., Honke, N., Scheu, S., Borkens, S., Gailus, N., Krings, C., Meryk, A., Kulawik, A., Cervantes-Barragan, L., Van Rooijen, N., Kalinke, U., Ludewig, B., Hengartner, H., Harris, N., Haussinger, D., Ohashi, P.S., Zinkernagel, R.M. & Lang, K.S. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 52, 25-32 (2010).

 

43     Lang, P.A., Merkler, D., Funkner, P., Shaabani, N., Meryk, A., Krings, C., Barthuber, C., Recher, M., Bruck, W., Haussinger, D., Ohashi, P.S. & Lang, K.S. Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur J Immunol 40, 2401-2408 (2010).

 

44     Gibbert, K., Dietze, K.K., Zelinskyy, G., Lang, K.S., Barchet, W., Kirschning, C.J. & Dittmer, U. Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol 185, 6179-6189 (2010).

 

45     Contaldo, C., Lindenblatt, N., Elsherbiny, A., Hogger, D.C., Borozadi, M.K., Vetter, S.T., Lang, K.S., Handschin, A.E. & Giovanoli, P. EPO REQUIRES ENOS TO COUNTERACT TNF-alpha INDUCED MICROCIRCULATORY DYSFUNCTION IN MURINE STRIATED MUSCLE. Shock (2010).

 

46     Navarini, A.A., *Lang, K.S., Verschoor, A., Recher, M., Zinkernagel, A.S., Nizet, V., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci U S A 106, 7107-7112 (2009).

 

47      Lang, P.A., Kasinathan, R.S., Brand, V.B., Duranton, C., Lang, C., Koka, S., Shumilina, E., Kempe, D.S., Tanneur, V., Akel, A., Lang, K.S., Foller, M., Kun, J.F., Kremsner, P.G., Wesselborg, S., Laufer, S., Clemen, C.S., Herr, C., Noegel, A.A., Wieder, T., Gulbins, E., Lang, F. & Huber, S.M. Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cell Physiol Biochem 24, 415-428 (2009).

 

48      Lang, P.A., Cervantes-Barragan, L., Verschoor, A., Navarini, A.A., Recher, M., Pellegrini, M., Flatz, L., Bergthaler, A., Honda, K., Ludewig, B., Ohashi, P.S. & Lang, K.S. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 113, 1045-1052 (2009).

 

49     Joly, S., Francke, M., Ulbricht, E., Beck, S., Seeliger, M., Hirrlinger, P., Hirrlinger, J., Lang, K.S., Zinkernagel, M., Odermatt, B., Samardzija, M., Reichenbach, A., Grimm, C. & Reme, C.E. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol 174, 2310-2323 (2009).

 

50     Cervantes-Barragan, L., Gil-Cruz, C., Pastelin-Palacios, R., Lang, K.S., Isibasi, A., Ludewig, B. & Lopez-Macias, C. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 39, 126-135 (2009).

 

51     Wang, K., Mahmud, H., Foller, M., Biswas, R., Lang, K.S., Bohn, E., Gotz, F. & Lang, F. Lipopeptides in the triggering of erythrocyte cell membrane scrambling. Cell Physiol Biochem 22, 381-386 (2008).

 

52     Lohning, M., Hegazy, A.N., Pinschewer, D.D., Busse, D., Lang, K.S., Hofer, T., Radbruch, A., Zinkernagel, R.M. & Hengartner, H. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med 205, 53-61 (2008).

 

53     Lang, P.A., Contaldo, C., Georgiev, P., El-Badry, A.M., Recher, M., Kurrer, M., Cervantes-Barragan, L., Ludewig, B., Calzascia, T., Bolinger, B., Merkler, D., Odermatt, B., Bader, M., Graf, R., Clavien, P.A., Hegazy, A.N., Lohning, M., Harris, N.L., Ohashi, P.S., Hengartner, H., Zinkernagel, R.M. & *Lang, K.S. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 14, 756-761 (2008).

 

54     Johansen, P., Storni, T., Rettig, L., Qiu, Z., Der-Sarkissian, A., Smith, K.A., Manolova, V., Lang, K.S., Senti, G., Mullhaupt, B., Gerlach, T., Speck, R.F., Bot, A. & Kundig, T.M. Antigen kinetics determines immune reactivity. Proc Natl Acad Sci U S A 105, 5189-5194 (2008).

 

55     Ittner, L.M., Schwerdtfeger, K., Kunz, T.H., Muff, R., Husmann, K., Grimm, C., Hafezi, F., Lang, K.S., Kurrer, M.O., Gotz, J., Born, W. & Fischer, J.A. Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma. Clin Sci (Lond) 114, 49-58 (2008).

 

56     Heikenwalder, M., Prinz, M., Zeller, N., Lang, K.S., Junt, T., Rossi, S., Tumanov, A., Schmidt, H., Priller, J., Flatz, L., Rulicke, T., Macpherson, A.J., Hollander, G.A., Nedospasov, S.A. & Aguzzi, A. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol 172, 1555-1570 (2008).

 

57     Falk, S., Wurdak, H., Ittner, L.M., Ille, F., Sumara, G., Schmid, M.T., Draganova, K., Lang, K.S., Paratore, C., Leveen, P., Suter, U., Karlsson, S., Born, W., Ricci, R., Gotz, M. & Sommer, L. Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell 2, 472-483 (2008).

 

58     Recher, M., *Lang, K.S., Navarini, A., Hunziker, L., Lang, P.A., Fink, K., Freigang, S., Georgiev, P., Hangartner, L., Zellweger, R., Bergthaler, A., Hegazy, A.N., Eschli, B., Theocharides, A., Jeker, L.T., Merkler, D., Odermatt, B., Hersberger, M., Hengartner, H. & Zinkernagel, R.M. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med 13, 1316-1323 (2007).

 

59     Lotscher, M., Recher, M., Lang, K.S., Navarini, A., Hunziker, L., Santimaria, R., Glatzel, M., Schwarz, P., Boni, J. & Zinkernagel, R.M. Induced prion protein controls immune-activated retroviruses in the mouse spleen. PLoS ONE 2, e1158 (2007).

 

60     Lang, K.S., Navarini, A.A., Recher, M., Lang, P.A., Heikenwalder, M., Stecher, B., Bergthaler, A., Odermatt, B., Akira, S., Honda, K., Hengartner, H. & Zinkernagel, R.M. MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. Eur J Immunol 37, 2434-2440 (2007).

 

61     Lang, K.S., Hegazy, A.N., Lang, P.A., Eschli, B., Lohning, M., Hengartner, H., Zinkernagel, R.M. & Recher, M. "Negative vaccination" by specific CD4 T cell tolerisation enhances virus-specific protective antibody responses. PLoS ONE 2, e1162 (2007).

 

62     Georgiev, P., Navarini, A.A., Eloranta, J.J., Lang, K.S., Kullak-Ublick, G.A., Nocito, A., Dahm, F., Jochum, W., Graf, R. & Clavien, P.A. Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse. Gut 56, 121-128 (2007).

 

63     Eschli, B., Zellweger, R.M., Wepf, A., Lang, K.S., Quirin, K., Weber, J., Zinkernagel, R.M. & Hengartner, H. Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus. J Virol 81, 11650-11657 (2007).

 

64     Cervantes-Barragan, L., Zust, R., Weber, F., Spiegel, M., Lang, K.S., Akira, S., Thiel, V. & Ludewig, B. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109, 1131-1137 (2007).

 

65     Navarini, A.A., Recher, M., Lang, K.S., Georgiev, P., Meury, S., Bergthaler, A., Flatz, L., Bille, J., Landmann, R., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci U S A 103, 15535-15539 (2006).

 

66     Kempe, D.S., Lang, P.A., Duranton, C., Akel, A., Lang, K.S., Huber, S.M., Wieder, T. & Lang, F. Enhanced programmed cell death of iron-deficient erythrocytes. FASEB J 20, 368-370 (2006).

 

67     Fink, K., Lang, K.S., Manjarrez-Orduno, N., Junt, T., Senn, B.M., Holdener, M., Akira, S., Zinkernagel, R.M. & Hengartner, H. Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur J Immunol 36, 2094-2105 (2006).

 

68     Dahm, F., Nocito, A., Bielawska, A., Lang, K.S., Georgiev, P., Asmis, L.M., Bielawski, J., Madon, J., Hannun, Y.A. & Clavien, P.A. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost 4, 2704-2709 (2006).

 

69     *Lang, K.S., Georgiev, P., Recher, M., Navarini, A.A., Bergthaler, A., Heikenwalder, M., Harris, N.L., Junt, T., Odermatt, B., Clavien, P.A., Pircher, H., Akira, S., Hengartner, H. & Zinkernagel, R.M. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. J Clin Invest 116, 2456-2463 (2006).

 

70     Wurdak, H., Ittner, L.M., Lang, K.S., Leveen, P., Suter, U., Fischer, J.A., Karlsson, S., Born, W. & Sommer, L. Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 19, 530-535 (2005).

 

71     Lang, K.S., Recher, M., Navarini, A.A., Freigang, S., Harris, N.L., van den Broek, M., Odermatt, B., Hengartner, H. & Zinkernagel, R.M. Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology. J Immunol 175, 5524-5531 (2005).

 

72     *Lang, K.S., Recher, M., Navarini, A.A., Harris, N.L., Lohning, M., Junt, T., Probst, H.C., Hengartner, H. & Zinkernagel, R.M. Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol 35, 738-745 (2005).

 

73     *Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H. & Zinkernagel, R.M. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 11, 138-145 (2005).

 

74     Recher, M., *Lang, K.S., Hunziker, L., Freigang, S., Eschli, B., Harris, N.L., Navarini, A., Senn, B.M., Fink, K., Lotscher, M., Hangartner, L., Zellweger, R., Hersberger, M., Theocharides, A., Hengartner, H. & Zinkernagel, R.M. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol 5, 934-942 (2004).

 

75     Lang, K.S., Myssina, S., Lang, P.A., Tanneur, V., Kempe, D.S., Mack, A.F., Huber, S.M., Wieder, T., Lang, F. & Duranton, C. Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl. Am J Physiol Renal Physiol 286, F1046-1053 (2004).

 

76     Lang, K.S., Myssina, S., Brand, V., Sandu, C., Lang, P.A., Berchtold, S., Huber, S.M., Lang, F. & Wieder, T. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ 11, 231-243 (2004).

 

77     Huber, S.M., Duranton, C., Henke, G., Van De Sand, C., Heussler, V., Shumilina, E., Sandu, C.D., Tanneur, V., Brand, V., Kasinathan, R.S., Lang, K.S., Kremsner, P.G., Hubner, C.A., Rust, M.B., Dedek, K., Jentsch, T.J. & Lang, F. Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte. J Biol Chem 279, 41444-41452 (2004).

 

78     Grau, R., Lang, K.S., Wernet, D., Lang, P., Niethammer, D., Pusch, C.M. & Handgretinger, R. Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hematopoietic stem cells in healthy individuals. Exp Mol Pathol 76, 90-98 (2004).

 

79     Myssina, S., Huber, S.M., Birka, C., Lang, P.A., Lang, K.S., Friedrich, B., Risler, T., Wieder, T. & Lang, F. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol 14, 2750-2757 (2003).

 

80     Lang, K.S., Weigert, C., Braedel, S., Fillon, S., Palmada, M., Schleicher, E., Rammensee, H.G. & Lang, F. Inhibition of interferon-gamma expression by osmotic shrinkage of peripheral blood lymphocytes. Am J Physiol Cell Physiol 284, C200-208 (2003).

 

81     Lang, K.S., Myssina, S., Tanneur, V., Wieder, T., Huber, S.M., Lang, F. & Duranton, C. Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn Schmiedebergs Arch Pharmacol 367, 391-396 (2003).

 

82     Lang, K.S., Mueller, M.M., Tanneur, V., Wallisch, S., Fedorenko, O., Palmada, M., Lang, F., Broer, S., Heilig, C.W., Schleicher, E. & Weigert, C. Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1. Kidney Int 64, 1338-1347 (2003).

 

83     Lang, K.S., Duranton, C., Poehlmann, H., Myssina, S., Bauer, C., Lang, F., Wieder, T. & Huber, S.M. Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ 10, 249-256 (2003).

 

84     Lang, K., Wagner, C., Haddad, G., Burnekova, O. & Geibel, J. Intracellular pH activates membrane-bound Na(+)/H(+) exchanger and vacuolar H(+)-ATPase in human embryonic kidney (HEK) cells. Cell Physiol Biochem 13, 257-262 (2003).

 

85     Lampert, A., Muller, M.M., Berchtold, S., Lang, K.S., Palmada, M., Dobrovinskaya, O. & Lang, F. Effect of dexamethasone on voltage-gated K+ channels in Jurkat T-lymphocytes. Pflugers Arch 447, 168-174 (2003).

 

86     Duranton, C., Huber, S., Tanneur, V., Lang, K., Brand, V., Sandu, C. & Lang, F. Electrophysiological properties of the Plasmodium Falciparum-induced cation conductance of human erythrocytes. Cell Physiol Biochem 13, 189-198 (2003).

 

87     Brand, V.B., Sandu, C.D., Duranton, C., Tanneur, V., Lang, K.S., Huber, S.M. & Lang, F. Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. Cell Physiol Biochem 13, 347-356 (2003).

 

88     Lang, K.S., Roll, B., Myssina, S., Schittenhelm, M., Scheel-Walter, H.G., Kanz, L., Fritz, J., Lang, F., Huber, S.M. & Wieder, T. Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem 12, 365-372 (2002).

 

89     Lang, K.S., Moris, A., Gouttefangeas, C., Walter, S., Teichgraber, V., Miller, M., Wernet, D., Hamprecht, K., Rammensee, H.G. & Stevanovic, S. High frequency of human cytomegalovirus (HCMV)-specific CD8+ T cells detected in a healthy CMV-seropositive donor. Cell Mol Life Sci 59, 1076-1080 (2002).

 

90     Lang, K.S., Fillon, S., Schneider, D., Rammensee, H.G. & Lang, F. Stimulation of TNF alpha expression by hyperosmotic stress. Pflugers Arch 443, 798-803 (2002).

 

91      Lang, K.S., Caroli, C.C., Muhm, A., Wernet, D., Moris, A., Schittek, B., Knauss-Scherwitz, E., Stevanovic, S., Rammensee, H.G. & Garbe, C. HLA-A2 restricted, melanocyte-specific CD8(+) T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against MelanA/MART1. J Invest Dermatol 116, 891-897 (2001).

 

92     Lang, F., Madlung, J., Bock, J., Lukewille, U., Kaltenbach, S., Lang, K.S., Belka, C., Wagner, C.A., Lang, H.J., Gulbins, E. & Lepple-Wienhues, A. Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation. Pflugers Arch 440, 902-907 (2000).

 

 

REVIEW ARTIKEL

 

1.     Lang, P.A., Recher, M., Haussinger, D. & Lang, K.S. Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. Cell Physiol Biochem 26, 263-272 (2010).

2.     Lang, K.S. Host mechanisms in viral hepatitis. Dig Dis 28, 25-30 (2010).

3.     Lang, K.S., Burow, A., Kurrer, M., Lang, P.A. & Recher, M. The role of the innate immune response in autoimmune disease. J Autoimmun 29, 206-212 (2007).

4.     Lang, F., Foller, M., Lang, K., Lang, P., Ritter, M., Vereninov, A., Szabo, I., Huber, S.M. & Gulbins, E. Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol 428, 209-225 (2007).

5.     Recher, M. & Lang, K.S. Innate (over)immunity and adaptive autoimmune disease. Curr Top Microbiol Immunol 305, 89-104 (2006).

6.     Lang, F., Lang, K.S., Lang, P.A., Huber, S.M. & Wieder, T. Osmotic shock-induced suicidal death of erythrocytes. Acta Physiol (Oxf) 187, 191-198 (2006).

7.     Lang, F., Lang, K.S., Lang, P.A., Huber, S.M. & Wieder, T. Mechanisms and significance of eryptosis. Antioxid Redox Signal 8, 1183-1192 (2006).

8.     Lang, K.S., Lang, P.A., Bauer, C., Duranton, C., Wieder, T., Huber, S.M. & Lang, F. Mechanisms of suicidal erythrocyte death. Cell Physiol Biochem 15, 195-202 (2005).

9.     Lang, F., Foller, M., Lang, K.S., Lang, P.A., Ritter, M., Gulbins, E., Vereninov, A. & Huber, S.M. Ion channels in cell proliferation and apoptotic cell death. J Membr Biol 205, 147-157 (2005).

10.   Recher, M., Hunziker, L., Ciurea, A., Harris, N. & Lang, K.S. Public, private and non-specific antibodies induced by non-cytopathic viral infections. Curr Opin Microbiol 7, 426-433 (2004).

11.   Lang, F., Lang, P.A., Lang, K.S., Brand, V., Tanneur, V., Duranton, C., Wieder, T. & Huber, S.M. Channel-induced apoptosis of infected host cells-the case of malaria. Pflugers Arch 448, 319-324 (2004).

12.   Lang, F., Gulbins, E., Szabo, I., Lepple-Wienhues, A., Huber, S.M., Duranton, C., Lang, K.S., Lang, P.A. & Wieder, T. Cell volume and the regulation of apoptotic cell death. J Mol Recognit 17, 473-480 (2004).

13.   Lang, F., Birka, C., Myssina, S., Lang, K.S., Lang, P.A., Tanneur, V., Duranton, C., Wieder, T. & Huber, S.M. Erythrocyte ion channels in regulation of apoptosis. Adv Exp Med Biol 559, 211-217 (2004).

 

14.   Lang, F., Lang, K.S., Wieder, T., Myssina, S., Birka, C., Lang, P.A., Kaiser, S., Kempe, D., Duranton, C. & Huber, S.M. Cation channels, cell volume and the death of an erythrocyte. Pflugers Arch 447, 121-125 (2003).