Biomedical application of nanoparticles

Nanoparticles (NPs) are small, microscopic, 3-dimensional particles, which, according to most definitions, do not exceed 100nm in at least one dimension. In collaboration with research groups in the Faculty of Chemistry, we are exploring the interaction of NPs with immune cells as well as their potential biomedical applications. NPs can be coupled to antibodies and we are currently testing, whether those constructs can be used to deliver therapeutic compounds to tumor cells or immune cells in order to enhance the anti-tumor activity of such interactions. A second area of major interest for us is the interaction of different classes of NPs with neutrophils as naturally phagocytosing target cells. Finally we are preparing a project (collaboration Dr. S. Hansen, senior physician in our department) to enhance the functionality of so-called cochlear implants (hearing aid devices). Although many aspects of the field are in it´s infancy, we are optimistic to accelerate the therapeutic application of NPs by these approaches.