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Publikationen der Arbeitsgruppe Molekulare Zellbiologie


1. Originalarbeiten in Journalen mit Peer Review

  • Ketteler J, Wittka A, Leonetti D, Roy VV, Estephan H, Maier P, Reis H, Herskind C, Jendrossek V, Paris F, Klein D. Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor-stroma interactions. Cell Death Dis. 2020 Apr 9;11(4):228. doi: 10.1038/s41419-020-2418-z.
  • Hlouschek J, Hansel C, Jendrossek V, Matschke J. The mitochondrial citrate carrier (SLC25A1) sustains redox homeostasis and mitochondrial metabolism supporting radioresistance of cancer cells with tolerance to cycling severe hypoxia. Front Oncol 8:170. doi: 10.3389/fonc.2018.00170.
  • Szymonowicz K*, Oeck S*, Malewicz NM, Jendrossek V. New insights into Protein Kinase B/Akt signaling: Role of localized Akt activation and compartment-specific target proteins for the cellular radiation response.Cancers (Basel) 2018 Mar 18;10(3). pii: E78. doi: 10.3390/cancers10030078 (Review).
  • Wiesemann A, Ketteler J, Slama A, Wirsdörfer F, Hager T, Roeck K, Engel D, Fischer J, Aigner C, Jendrossek V, Klein D. Inhibition of radiation-induced Ccl2 signaling protects murine lungs from vascular dysfunction and endothelial cell loss. Antioxid Redox Signal. 2018 Feb 20. doi: 10.1089/ars.2017.7458. [Epub ahead of print]
  • Oeck S, Malewicz NM, Hurst S, Al-Refae K, Krysztofiak A, Jendrossek V. The Focinator v2-0 - Graphical interface, 4-channels, colocalization analysis and cell phase identification. Radiat Res 2017 Jul;188(1):114-120. doi: 10.1667/RR14746.1. Epub 2017 May 11.
  • Westendorf AW, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Jendrossek V Hypoxia enhances immunosuppression by inhibiting CD4+ effector function and promoting Treg activity Cell Physiol Biochem 2017 Mar 8;41(4):1271-1284.
  • de Leve S*, Wirsdörfer F*, Cappuccini F, Schütze A, Meyer AV, Röck K, Thompson LF, Fischer JW, Stuschke, M, Jendrossek V. Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of pre-fibrotic macrophage clusters in irradiated lungs FASEB J 2017 Jul;31(7):2869-2880. doi: 10.1096/fj.201601228R. Epub 2017 Mar 21.
  • Oeck S, Al-Refae K, Riffkin H, Wiel G, Klein D, Handrick R, Iliakis G, Jendrossek V. Somatic Akt1-E17K mutation enhances DNA double strand break repair and promotes radiation resistance (accepted for publication in Sci Rep 2017 Feb 17;7:42700. doi: 10.1038/srep42700.
  • Panic A, Kettler J, Reis H, Sak A, Herskind C, Maier P, Rübben H, Jendrossek V, Klein D. Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance Sci Rep 2017 Jan 23;7:41138. doi: 10.1038/srep41138.
  • Guberina M, Eberhardt W, Stuschke M, Gauler T, Heinzelmann F, Cheufou D, Kimmich M, Friedel G, Schmidberger H, Darwiche K, Jendrossek V, Schuler M, Stamatis G, Pöttgen C. Heart dose exposure as a prognostic marker after radiotherapy for resectable stage IIIA/B NSCLC: secondary analysis of a randomized trial. Ann Oncol 2017, 28(5):1084-1089. doi: 10.1093/annonc/mdx069.
  • Kleemann M, Bereuther J, Fischer S, Marquart K, Hänle S, Unger K, Jendrossek V, Riedel CU, Handrick R, Otte K. Investigation on tissue-specific effects of pro-apoptotic micro RNAs revealed miR-147b as potential biomarker in ovarian cancer Oncotarget 2017 Mar 21;8(12):18773-18791. Nov 4 (2016) doi: 10.18632/oncotarget.13095. [Epub ahead of print]
  • Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V. Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression Antioxid Redox Signal 2017 Apr 10;26(11):563-582. doi: 10.1089/ars.2016.6748. Epub 2016 Nov 14.
  • Mahnke K, Useliene J, Ring S, Kage P, Jendrossek V, Robson SC, Bylaite-Bucinskiene M, Steinbrink K, Enk AH. Down-regulation of CD62L shedding in T cells by CD39+ regulatory T cells leads to defective sensitization in contact hypersensitivity reaction. J Invest Dermatol 2017 Jan;137(1):106-114. doi: 10.1016/j.jid.2016.08.023.
  • Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I, Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber K. Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance in Cancer Lett 2017 Feb 1;386:87-99. doi: 10.1016/j.canlet.2016.11.014.
  • Klein D, Schmetter A, Imzak R, Wirsdörfer F, Unger K, Jastrow H, Stuschke M, Jendrossek V. Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of metastasis. Antioxid Redox Signal. 24(2):53-69 (2016). doi: 10.1089/ars.2014.6183.
  • Matschke J, Riffkin H, Klein D, Handrick R, Lüdemann L, Metzen E, Shlomi T, Stuschke M, Jendrossek V. Targeted inhibition of glutamine-dependent glutathione metabolism overcomes death resistance induced by chronic cycling hypoxia Antioxid Redox Signal Jul 10;25(2):89-107 (2016). doi: 10.1089/ars.2015.6589.
  • Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V.. Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia Radiat Oncol Jun 1;11(1):75 (2016). doi: 10.1186/s13014-016-0647-1.
  • Wirsdörfer F*, de Leve S*, Cappuccini F*, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey J, Blackburn MR, Westendorf A, Stuschke M, Jendrossek V. Extracellular adenosine production by ecto-5´-nucleotidase (CD73) enhances radiation-induced lung fibrosis. Cancer Res May 15;76(10):3045-56 (2016). doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26. * shared first.
  • Wolfsperger F, Hogh-Binder SA, Schittenhelm J, Psaras T, Ritter V, Bornes L Huber SM, Jendrossek V, Rudner J. Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms. Cell Death Dis Jan 14;7 e2039 (2016) doi: 10.1038/cddis.2015.405.
  • Schütze A, Vogeley C, Gorges TM, Twarock S, Butschan J, Babayan A, Klein D, Knauer S, Metzen E, Müller V, Jendrossek V, Pantel K, Milde-Langosch K, Fischer JW, Röck K. RHAMM splice variants confer radiosensitivity in human breast cancer Oncotarget 7(16):21428-40 (2016). doi: 10.18632/oncotarget.7258.
  • Ring S, Pushkarevskaya A, Schild H, Probst HC, Jendrossek V, Wirsdörfer F, Ledent C, Robson SC, Enk AH, Mahnke K. Regulatory T cell-derived adenosine induces DC migration through the Epac-Rap1 pathway J Immunol 194(8):3735-44 (2015).
  • Pöttgen C, Stuschke M, Graupner B, Theegarten D, Gaiuler T, Jendrossek V, Freitag L, Jawad JA, Gkika E, Wohlschläger J, Welter S, Hoiczyk M, Schuler M, Stamatis G, Eberhardt W. Prognostic model for long-term survival of locally advanced non small cell lung cancer patients after neoadjuvant radiochemotherapy and resection:Integrating clinical and histopathological factors. BMC Cancer 15(1):363 (2015).
  • Klein D, Schmitz T, Verhelst V, Panic A, Schenck M, Reis H, Drab M, Sak A, Herskind C, Maier P and Jendrossek V. Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors. Oncogenesis May 18;4:e148 (2015). doi: 10.1038/oncsis.2015.9.
  • Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, and Rauh D. Covalent-allosteric kinase inhibitors. Angew Chem Int Ed Engl 54(35):10313-6 (2015). [Epub ahead of print] Jun 25, 2015. doi: 10.1002/anie.201502142.
  • Oeck S, Malewicz NM, Hurst S, Rudner J, Jendrossek V: The Focinator - New open-source tool for high-throughput foci evaluation of DNA damage Radiat Oncol 10;163 (2015).
  • Chometon G, Cappuccini F, Raducanu A, Aumailley M, Jendrossek V. The membrane-targeted alkylphosphocholine Erufosine interferes with survival signals from the extracellular matrix Anticancer Agents in Medicinal Chemistry May; 14(4):578-91(2014).
  • Wirsdörfer F, Cappuccini F, Niazman M, de Leve S, Westendorf AM, Lüdemann L, Stuschke M, Jendrossek V. Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells. Radiation Oncology Apr 25; 9(1):98 (2014).
  • Ontikatze T, Rudner J, Handrick R, Belka C, Jendrossek V. Dihydroartemisinin is a hypoxia-active anticancer drug in colorectal cancer cells. Frontiers Oncol May 19; 4:116 (2014).
  • Klein D, Meißner N, Kleff V, Jastrow H, Yamaguchi M, Palm T, Ergün S, Jendrossek V. Nestin(+) tissue-resisdent multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling. Frontiers Oncol Jun 26, 4:169 (2014).
  • Eldh T, Heinzelmann F, Velalakan A, Budach W, Belka C, Jendrossek V. Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- and dose-dependent. Strahlenther Onkol 188(3):274-81 (2012).
  • Kessler D, Grün GC, Morgner J, Reis H, Schmid KW, Jendrossek V. Concerted Action of Rab11 and Rab25 in Vesicle Trafficking during Cell Migration Cell Physiol Biochem 29: 647-656 (2012).
  • Henke G, Meier V, Lindner L H, Eibl H, Bamberg M, Belka C, Budach W, Jendrossek V. Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: a study in NMRI nu/nu mice. Radiat Oncol Oct 18;7(1):172 (2012).
  • Rudner J, Elsässer SJ, Jendrossek V, Huber S. Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis. Biochem Pharmacol 81(1):32-42 (2011).
  • Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff, Ute Fischer, David Köhler D, Stuschke M, Jendrossek V. New insights into the molecular pathology of radiation-induced pneumopathy Radiother Oncol 101(1):86-92 (2011).
  • Ranta F, Leveringhaus J, Theilig D, Hennige AM, Hildebrand D, Handrick R, Jendrossek V, Bosch F, Schulze-Osthoff K, Häring HU, Ullrich S.. PKCδ regulates proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLOS one 6 (12);e28828 (2011).
  • Rudner J, Elsaesser SJ, Müller AC, Belka C, Jendrossek V. Differential effects of anti-apoptic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis. Biochem Pharmacol. 79: 10-20 (2010).
  • Li M, Jung A, Ganswindt U, Marini P, Friedl A, Daniel PT, Lauber K, Jendrossek V, Belka C. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathway. Biochem Pharmacol. 79:122-129 (2010).
  • Handrick R, Ontikatze T, Bauer KD, Freier F, Rübel A, Dürig J, Belka C, Jendrossek V. Dihydroartemisinin induces apoptosis by a Bak-dependent intrinsic pathway. Mol Cancer Ther 9(9):2497-510 (2010).
  • Rudner J, Ruiner CE, Handrick R, Eibl H, Belka C, Jendrossek V. The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation. Radiation Oncology 5:108 (2010).
  • Handrick R, Ganswindt U, Faltin H, Goecke B, Daniel PT, Budach W, Belka C, Jendrossek V. Combined action of celecoxib and ionizing radiation in prostate cancer cells is independent of proapoptotic Bax. Radiother Oncol 90, 413-421 (2009).
  • Niyazi M, Marini P, Daniel PT, Humphreys R, Jendrossek V, Belka C. Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade. Strahlenther Onkol 185, 8-18 (2009).
  • Rudner J, Mueller A-C, Matzner N, Huber S, Handrick R, Belka C, Jendrossek V. The additional loss of Bak and not the lack of the protein tyrosine kinase p56/Lck in one JCaM1.6 subclone caused pronouced apoptosis resistants in response to stimuli of the intrinsic pathway. Apoptosis 14(5):711-20 (2009).
  • Niyazi M, Marini P, Daniel PT, Humphreys R, Jendrossek V, Belka C. Efficacy of a triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin. Oncol Rep 21:1455-1460 (2009).
  • Marini P, Budach W, Niyazi M, Junginger D, Stickl S, Jendrossek V, Belka C. Combination of pro-apoptotic TRAIL-receptor antibodies with ionizing radiation strongly increases long term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys 75:198-202 (2009).
  • Henke G, Lindner LH, Vogeser M, Eibl H, Wörner J, Müller AC, Bamberg M, Wachholz K, Belka C, Jendrossek V. Pharmacokinetics and biodistribution of Erufosine in nude mice - implications for combination with radiotherapy. Radiation Oncology 4:46 (2009).
  • Grandoch M, Rose A, ter Braak M, Jendrossek V, Rübben H, Fischer JW, Schmidt M, Weber AA. Epac inhibits migration and proliferation of human prostate carcinoma cells. Br J Cancer 101(12):2038-42. (2009).
  • Jendrossek V, Henkel M, Hennenlotter J, Vogel U, Ganswindt U, Müller I, Handrick R, Kuczyk M, Stenzl A, Belka C. Analysis of complex PKB/Akt signaling pathways in human prostate cancer samples Brit J Urol 102, 371-382 (2008).
  • Müller AC, Handrick R, Elsaesser SJ, Rudner J, Henke G, Ganswindt U, Belka C, Jendrossek V. Importance of Bak for celecoxib-induced apoptosis. Biochem Pharmacol 76(9), 1082-1096 (2008).
  • Brand V, Koka S, Lang C, Jendrossek V, Huber SM, Gulbins E, Lang F. Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei- infected mice). Cell Physiol Biochem 22(5-6), 405-412 (2008).

2. Reviews

  • Li M, Jendrossek, V, Belka: The role of PDGF in cancer research. Radiation Oncology 2, 5 (2007).
  • Chometon G, Jendrossek V: Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy. Clin Transl Oncol 11, 75-81 (2009).
  • Jendrossek V. Emerging targets for the modulation of apoptosis resistance in anticancer treatment. Eur J Oncol Pharmacy 4(2), 6-8 (2010).
  • Jendrossek V. The intrinsic apoptosis pathways as a target in anticancer therapy Current Pharm Biotechnology 13(8):1426-38 (2012).
  • Jendrossek V, Fulda S. First EACR conference on Cell Death in Cancer, Amsterdam, Netherlands, 26-28 Januar 2012. Cell Death Differentiation 19(8):1408-10 (2012).
  • Jendrossek V. Targeting apoptosis pathways by Celecoxib in cancer. Cancer Lett 2332(2):313-324 (2013).
  • Jendrossek V, Fulda S. Second EACR conference on Cell death in Cancer, Amsterdam, Netherlands, 2014. Cell Death Differentiation 21(7):1180-82 (2014).
  • Wirsdörfer F, Jendrossek V. The role of lymphocytes in radiotherapy-induced adverse late effects in the lung Front Immunol 2016, Dec 14;7:591. doi: 10.3389/fimmu.2016.00591. eCollection 2016. ReviewWirsdörfer F, Jendrossek V. Modeling DNA-damage induced pneumopathy in mice: insight from danger signaling cascades Radiat Oncol Aug 24;12(1):142 (2017). doi: 10.1186/s13014-017-0865-1. Review.

3. Buchkapitel

  • Jendrossek V, Belka C. Radiation therapy and apoptosis. In: Apoptosis and cancer therapy (Fulda S, Debatin K-M.eds.). Wiley VCH, pp.1049-177 (2006).
  • Andratschke N, Belka C, Jendrossek V. Rolle von Kinase-Signalwegen. In Radioonkologie, Grundlagen und Klinik (Bamberg M, Molls, M und Sack H) Zuckerschwerdt Verlag (2009).
  • Jendrossek V. Exploiting Celecoxib in cancer therapy. In: Mitochondria: The anti-cancer target for the Third Millennium (Neuzil J et al., Editors). Springer Science and Business, Media Dordrecht 2014, Chapter 5 (2014). DOI 10.1007/978-94-017-8984-4_5.

4. Kommentare/Editorials

  • Jendrossek V. Radioprotektion durch TOLL-like Rezeptor-5-vermittelte Aktivierung von NF-kB. Strahlenther Onkol 184;612-614 (2008).
  • Lauber K, Munoz LE, Berens C, Jendrossek V, Belka C, Herrmann M. Apoptosis induction and tumor cell repopulation: The yin and yang of radiotherapy. Radiat Oncol 6:176 (2011).

 

 

 

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