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Publikationen von 2015 bis 2019


  • Shannan B, Matschke J, Chauvistre H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Livingstone E, Varaljai R, Hoewner A, Horn S, J Klode J, Stuschke M, Scheffler B, Marchetto A, Sannino G, Grünewald TGP, Schadendorf D, Jendrossek V, A Roesch A. Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E-inhibition in melanoma Eur J Cancer 2019 Mar;109:137-153. doi: 10.1016/j.ejca.2018.12.024. Epub 2019 Feb 2.
  • de Leve S, Wirsdörfer F, Jendrossek V The CD73/Ado system - a new player in RT induced adverse late effects. Cancers 2019 Oct 16;11(10). pii: E1578. doi: 10.3390/cancers11101578. (Review).
  • Dünker N and Jendrossek V. Implementation of the chick chorioallantoic membrane (CAM) model in radiation biology and experimental radiation oncology research. Cancers 2019 Oct 7;11(10). pii: E1499. doi: 10.3390/cancers11101499. (Review).
  • Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM. High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation. Sci Rep. 2019 Feb 28;9(1):3148. doi: 10.1038/s41598-019-39760-8.
  • Ketteler J, Panic A, Reis H, Wittka A, Meier P, Herskind C, Yague E, Jendrossek V, Klein D. Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1 J Clin Med 2019 Mar 12;8(3). pii: E348. doi: 10.3390/jcm8030348.
  • Steer A, Cordes N, Jendrossek V, Klein D. Impact of cancer-associated fibroblast on the radiation-response of solid xenograft tumors. Front Mol Biosci 2019 Aug 13;6:70. doi: 10.3389/fmolb.2019.00070. eCollection 2019.
  • de Leve S, Wirsdörfer W, Jendrossek V Targeting the immunomodulatory CD73/adenosine system to improve the therapeutic gain of radiotherapy Front Immunol Apr 5 10; 698 (2019) doi: 10.3389/fimmu.2019.00698) (Review).
  • Wiesemann A, Ketteler J, Slama A, Wirsdörfer F, Hager T, Roeck K, Engel D, Fischer J, Aigner C, Jendrossek V, Klein D. Inhibition of radiation-induced Ccl2 signaling protects murine lungs from vascular dysfunction and endothelial cell loss. Antioxid Redox Signal. 2019 Jan 10;30(2):213-231. doi: 10.1089/ars.2017.7458.
  • Hlouschek J, Hansel C, Jendrossek V, Matschke J. The mitochondrial citrate carrier (SLC25A1) sustains redox homeostasis and mitochondrial metabolism supporting radioresistance of cancer cells with tolerance to cycling severe hypoxia. Front Oncol 2018, 8:170. doi: 10.3389/fonc.2018.00170.
  • Szymonowicz K, Oeck S, Krysztofiak A, van der Linden J, Iliakis G, Jendrossek V. Restraining Akt1 phosphorylation attenuates repair of radiation-induced DNA double strand breaks and reduces survival of irradiated cancer cells Int J Med Sci 2018, 31:19(8). pii: E2233. doi: 10.3390/ijms19082233.
  • Hlouschek J, Ritter V, Wirsdörfer F, Klein D, Jendrossek V, Matschke J. Targeting SLC25A10 alleviates improved antioxidant capacity and associated radiation resistance of cancer cells induced by adaptation to chronic-cycling hypoxia Cancer Lett 2018, 439:24-38.
  • Oeck,S, Szymonowicz K, Wiel G, Krysztofiak A, Lambert J, Koska, B, Iliakis G, Timmermann B, Jendrossek V. Relating linear energy transfer to the formation and resolution of DNA repair foci after irradiation with equal doses of X-ray photons, plateau or Bragg-peak protons. Int J Med Sci 2018, 19; 3779.
  • Szymonowicz K, Oeck S, Malewicz NM, Jendrossek V. New insights into Protein Kinase B/Akt signaling: Role of localized Akt activation and compartment-specific target proteins for the cellular radiation response. Cancers (Basel) 2018 Mar 18;10(3). pii: E78. doi: 10.3390/cancers10030078. (Review).
  • Wirsdörfer F, de Leve S, and Jendrossek V. Combining radiotherapy and immunotherapy in lung cancer: can we expect limitations due to altered normal tissue toxicity? Int J Mol Sci. 2018 Dec 21;20(1). pii: E24. doi: 10.3390/ijms20010024. (Review).
  • Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V. Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression Antioxid Redox Signal 2017 Apr 10;26(11):563-582. doi: 10.1089/ars.2016.6748.
  • Mahnke K, Useliene J, Ring S, Kage P, Jendrossek V, Robson SC, Bylaite-Bucinskiene M, Steinbrink K, Enk AH. Down-regulation of CD62L shedding in T cells by CD39+ regulatory T cells leads to defective sensitization in contact hypersensitivity reaction. J Invest Dermatol 2017 Jan;137(1):106-114. doi: 10.1016/j.jid.2016.08.023.
  • Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I, Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber K. Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance in Cancer Lett 2017 Feb 1;386:87-99. doi: 10.1016/j.canlet.2016.11.014.
  • Panic A, Kettler J, Reis H, Sak A, Herskind C, Maier P, Rübben H, Jendrossek V, Klein D. Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance Sci Rep 2017 Jan 23;7:41138. doi: 10.1038/srep41138.
  • Oeck S, Al-Refae K, Riffkin H, Wiel G, Klein D, Handrick R, Iliakis G, Jendrossek V. Somatic Akt1-E17K mutation enhances DNA double strand break repair and promotes radiation resistance Sci Rep 2017 Feb 17;7:42700. doi: 10.1038/srep42700.
  • Westendorf AW, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Jendrossek V Hypoxia enhances immunosuppression by inhibiting CD4+ effector function and promoting Treg activity Cell Physiol Biochem 2017 Mar 8;41(4):1271-1284.
  • Guberina M, Eberhardt W, Stuschke M, Gauler T, Heinzelmann F, Cheufou D, Kimmich M, Friedel G, Schmidberger H, Darwiche K, Jendrossek V, Schuler M, Stamatis G, Pöttgen C. Heart dose exposure as a prognostic marker after radiotherapy for resectable stage IIIA/B NSCLC: secondary analysis of a randomized trial. Ann Oncol 2017, 28(5):1084-1089. doi: 10.1093/annonc/mdx069.
  • de Leve S, Wirsdörfer F, Cappuccini F, Schütze A, Meyer AV, Röck K, Thompson LF, Fischer JW, Stuschke, M, Jendrossek V. Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of pre-fibrotic macrophage clusters in irradiated lungs FASEB J Jul;31(7):2869-2880 (2017). doi: 10.1096/fj.201601228R. Epub 2017 Mar 21.
  • Oeck S, Malewicz NM, Hurst S, Al-Refae K, Krysztofiak A, Jendrossek V. The Focinator v2-0 - Graphical interface, 4-channels, colocalization analysis and cell phase identification. Radiat Res 2017 Jul;188(1):114-120. doi: 10.1667/RR14746.1. Epub 2017 May 11.
  • Kleemann M, Bereuther J, Fischer S, Marquart K, Hänle S, Unger K, Jendrossek V, Riedel CU, Handrick R, Otte K. Investigation on tissue-specific effects of pro-apoptotic micro RNAs revealed miR-147b as potential biomarker in ovarian cancer Oncotarget 2017 Mar 21;8(12):18773-18791. doi: 10.18632/oncotarget.13095.
  • Wirsdörfer F, Jendrossek V. Modeling DNA-damage induced pneumopathy in mice: insight from danger signaling cascades. Radiat Oncol Aug 24;12(1):142 (2017). doi: 10.1186/s13014-017-0865-1. (Review).
  • Klein D, Schmetter A, Imzak R, Wirsdörfer F, Unger K, Jastrow H, Stuschke M, Jendrossek V. Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of metastasis. Antioxid Redox Signal. 24(2):53-69 (2016). doi: 10.1089/ars.2014.6183.
  • Wolfsperger F, Hogh-Binder SA, Schittenhelm J, Psaras T, Ritter V, Bornes L Huber SM, Jendrossek V, Rudner J. Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms. Cell Death Dis Jan 14;7 e2039 (2016) doi: 10.1038/cddis.2015.405.
  • Schütze A, Vogeley C, Gorges TM, Twarock S, Butschan J, Babayan A, Klein D, Knauer S, Metzen E, Müller V, Jendrossek V, Pantel K, Milde-Langosch K, Fischer JW, Röck K. RHAMM splice variants confer radiosensitivity in human breast cancer Oncotarget 7(16):21428-40 (2016). doi: 10.18632/oncotarget.7258.
  • Wirsdörfer F*, de Leve S*, Cappuccini F*, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey J, Blackburn MR, Westendorf A, Stuschke M, Jendrossek V. Extracellular adenosine production by ecto-5´-nucleotidase (CD73) enhances radiation-induced lung fibrosis. Cancer Res May 15;76(10):3045-56 (2016). doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26. * shared first.
  • Matschke J, Riffkin H, Klein D, Handrick R, Lüdemann L, Metzen E, Shlomi T, Stuschke M, Jendrossek V. Targeted inhibition of glutamine-dependent glutathione metabolism overcomes death resistance induced by chronic cycling hypoxia Antioxid Redox Signal Jul 10;25(2):89-107 (2016). doi: 10.1089/ars.2015.6589.
  • Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V.. Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia Radiat Oncol Jun 1;11(1):75 (2016). doi: 10.1186/s13014-016-0647-1.
  • Ring S, Pushkarevskaya A, Schild H, Probst HC, Jendrossek V, Wirsdörfer F, Ledent C, Robson SC, Enk AH, Mahnke K. Regulatory T cell-derived adenosine induces DC migration through the Epac-Rap1 pathway J Immunol 194(8):3735-44 (2015).
  • Pöttgen C, Stuschke M, Graupner B, Theegarten D, Gaiuler T, Jendrossek V, Freitag L, Jawad JA, Gkika E, Wohlschläger J, Welter S, Hoiczyk M, Schuler M, Stamatis G, Eberhardt W. Prognostic model for long-term survival of locally advanced non small cell lung cancer patients after neoadjuvant radiochemotherapy and resection:Integrating clinical and histopathological factors. BMC Cancer 15(1):363 (2015).
  • Klein D, Schmitz T, Verhelst V, Panic A, Schenck M, Reis H, Drab M, Sak A, Herskind C, Maier P and Jendrossek V. Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors. Oncogenesis May 18;4:e148 (2015). doi: 10.1038/oncsis.2015.9.
  • Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, and Rauh D. Covalent-allosteric kinase inhibitors. Angew Chem Int Ed Engl 54(35):10313-6 (2015). [Epub ahead of print] Jun 25, 2015. doi: 10.1002/anie.201502142.
  • Oeck S, Malewicz NM, Hurst S, Rudner J, Jendrossek V: The Focinator - New open-source tool for high-throughput foci evaluation of DNA damage Radiat Oncol 10;163 (2015).


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