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Publikationen der Arbeitsgruppe Molekulare Genetik (ab 2019)


  • Cao Y, Kitanovski S, Küppers R, Hoffmann D (2021) UMI or not UMI, that is the question for scRNA-seq zero-inflation. Nat Biotechnol, 39, 158-159 (letter)
  • Montesinos-Rongen M, Terrao M, May C, Marcus K, Blümcke I, Hellmich M, Küppers R, Brunn A, Deckert M. (2021) The process of somatic hypermutation increases polyreactivity for CNS antigens in primary CNS lymphoma. Haematologica, 106, 708-717
  • Weniger MA, Küppers R (2021) Molecular biology of Hodgkin lymphoma. Leukemia, 35, 968-981 (review)
  • Kibler A, Budeus B, Homp E, Bronischewski K, Berg V, Sellmann L, Murke F, Heinold A, Heinemann FM, Lindemann M, Bekeredjian-Ding I, Horn PA, Kirschning C, Küppers R, Seifert M. (2021) Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life. J Exp Med., 218, e20201952
  • Küppers R. (2021) The life of B cells according to JEM. J Exp Med, 218, e20210647, (viewpoint)
  • Küppers R. (2021) OBF1 and OCT1/2 regulate the germinal center B-cell program. Blood, 137, 2862-2863 (commentary)
  • Budeus B, Kibler A, Brauser M, Homp E, Bronischewski K, Ross A, Görgens A, Weniger MA, Dunst J, Kreslavsky T, da Conceição Castro SV, Murke F, Oakes CC, Rusch P, Andrikos D, Kern P, Köninger A, LindemannM, Johansson P, Hansen W, Lundell A-C, Rudin A, Dürig J, Giebel B, Hoffmann D, Küppers R, Seifert M. (2021) Human cord blood B cells differ from the adult counterpart by conserved Ig repertoires and accelerated response dynamics. J Immunol, 206, 2839-2851
  • Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann M-L, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R*, Schlesner M*, Siebert R.* (2021) Mutational mechanisms shaping the coding and non-coding genome of germinal center derived B-cell lymphomas. Leukemia, 35, 2002-2016 (*shared senior authors)
  • ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (1341 authors, RK as coauthor). (2020) Pan-cancer analysis of whole genomes. Nature, 578, 82-93
  • Janssen A, Hidalgo JV, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizi AR, Bronsert P, Kock S, Schmitt-Gräff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudaskov D, Kasatskaya S, Frenkel F, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, Kuball J. (2020) γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivity. Cancer Immunol Res, 8, 530-543
  • Rosenwald A, Küppers R (2020) Pathology and molecular pathology of Hodgkin lymphoma. Chapter 3, p. 47-68. in Hodgkin lymphoma: a comprehensive overview. 3rd Ed., Edited by A. Engert and A. Younes. Springer International Publishing, Basel
  • Wierzbinska JA, Toth R, Ishaque N, Rippe K, Mallm J-P, Klett LC, Mertens D, Zenz T, Hielscher T, Seifert M, Küppers R, Assenov Y, Lutsik P, Stilgenbauer S, Roessner PM, Seiffert M, Byrd J, Oakes CC, Plass C, Lipka DB. (2020) Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL. Genome Med, 12, 29
  • Johansson P, Klein-Hitpass L, Budeus B, Kuhn M, Lauber C, Seifert M, Roeder I, Pförtner R, Stuschke M, Dührsen U, Eckstein A, Dürig J, Küppers R. (2020) Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the MALT subtype by whole genome, whole exome and targeted sequencing. Cancers, 12, 986
  • Thurner L, Hartmann S, Fadle N, Regitz E, Kemele M, Kim Y-J, Bohle RM, Nimmesgern A, von Müller l, Kempf VAJ, Weniger MA, Neumann F, Schneider N, Vornanen M, Sundström C, de Leval L, Engert A, Eichenauer DA, Küppers R, Preuss K-D, Hansmann M-L, Pfreundschuh M. (2020) Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma. Nat Commun, 11, 2465
  • Küppers R (2020) The genomic landscape of HIV-associated plasmablastic lymphoma. Blood Cancer Dis, 1, 23-25 (commentary)
  • Nadeu F, Martin-García D, Clot G, Diaz A, Duran-Ferrer M, Navarro A, Vilarrasa-Blasi R, Kulis M, Royo R, López C, Chapaprieta V, Puiggros M, Castellano G, Costa D, Aymerich M, Jares P, Espinet B, Muntañola A, Ribera-Cortada I, Siebert R, Colomer D, Torrents D, Giné E, López-Guillermo A, Küppers R, Martin-Subero I, Puente XS, Beà S, Campo E. (2020) Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes. Blood, 136, 1419-1432
  • Thurner L, Hartmann S, Neumann F, Hoth M, Stilgenbauer S, Küppers R, Preuss K-D, Bewarder M. (2020) Role of specific B-cell receptor antigens in lymphomagenesis. Front Oncol, 10:604685
  • Hartmann S, Goncharova O, Portyanko A, Sabattini, E, Meinel J, Küppers R, Agostinelli C, Pileri SA, Hansmann M-L. (2019) CD30-expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis to Hodgkin lymphoma. Mod Pathol, 32, 37-47
  • Schuhmacher B, Bein J, Rausch T, Benes V, Tousseyn T, Vornanen M, Ponzoni M, Thurner L, Gascoyne R, Steidl C, Küppers R, Hansmann ML, Hartmann S. (2019) JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte rich large B-cell lymphoma. Haematologica, 104, 330-337
  • Seifert M, Scholtysik R, Küppers R. (2019) Origin and pathogenesis of B cell lymphomas. Meth. Mol. Biol., 1956, 1-33 (review)
  • Küppers R, Schneider M, Hansmann ML. (2019) Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells. Meth. Mol. Biol., 1956, 61-75 (review)
  • Küppers R. Editor (2019) Lymphoma. Methods and Protocols. 2nd Edition. Meth Mol Biol, 1956 (book)
  • López C, Kleinheinz K, Aukema SM, Rohde M, Bernhart SH, Wagener R, Hübschmann D, Toprak UH, Raimondi F, Kreuz M, Waszak SM, Huang Z, Sieverling L, Paramasivam N, Seufert J, Sungalee S, Russell RB, Bausinger J, Kretzmer H, Ammerpohl O, Bergmann AK, Binder H, Borkhardt A, Brors B, Claviez A, Doose G, Feuerbach L, Haake A, Hansmann M-L, Hoell J, Hummel M, Korbel JO, Lawerenz C, Lenze D, Radlwimmer B, Richter J, Rosenstiel P, Rosenwald A, Schilhabel MB, Stein H, Stilgenbauer S, Stadler PF, Szczepanowski M, Weniger MA, Zapatka M, Eils R, Lichter P, Loeffler M, Möller P, Trümper L, Klapper W, Hoffmann S*, Küppers R*, Burkhardt B*, Schlesner M*, Siebert R* (2019) Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma. Nat Commun, 10, 1459 (*shared senior authors)
  • Hüllein J, Slabicki M, Rosolowski M, Jethwa A, Habringer S, Tomska K, Kurilov R, Lu J, Scheinost S, Wagener R, Huang Z, Lukas M, Yavorsko O, Helferich H, Scholtysik R, Bonneau K, Tedeso D, Küppers R, Klapper W, Pott C, Stilgenbauer S, Burkhardt B, Löffler M, Trümper L, Hummel M, Brors B, Zapatka M, Siebert R, Kreuz M, Keller U, Huber W, Zenz T (2019) MDM4 is targeted by 1q gain and drives disease in Burkitt lymphoma. Cancer Res, 79, 3125-3138
  • Küppers R (2019) CD81 as target for B cell lymphomas. J Exp Med, 216, 1469-1470. (commentary)
  • Goncharova O, Flinner N, Bein J, Döring C, Donnadieu E, Rikirsch S, Herling M, Küppers R, Hansmann M-L, Hartmann S (2019) Migration properties distinguish tumor cells of classical Hodgkin lymphoma from anaplastic large cell lymphoma cells. Cancers, 11, 1484
  • Bankov K, Döring C, Ustaszewski A, Giefing M, Herling M, Cencioni C, Spallotta F, Gaetano C, Küppers R, Hansmann M-L, Hartmann S. (2019) Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from Brentuximab-Vedotin-induced injury. Cancers, 11, 1687

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