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Publikationen der Arbeitsgruppe Molekulare Genetik (2015 - 2018)


  • Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R (2018) IG-MYC-positive neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas. Blood, 132, 2280-2285
  • Unterluggauer JJ, Prochazka K, Tomazic PV, Huber HJ, Seeboeck R, Fechter K, Steinbauer E, Gruber V, Feichtinger J, Pichler M, Weniger MA, Küppers R, Sill H, Schicho R, Neumeister P, Beham-Schmid C, Deutsch AJA, Haybaeck J (2018) Expression profile of translation initiation factor eIF2B5 in diffuse large B cell lymphoma and its correlation to clinical outcome. Blood Cancer J, (correspondence) 8:79
  • Weniger MA, Tiacci E, Schneider S, Arnolds J, Rüschenbaum S, Duppach J, Seifert M, Döring C*, Hansmann M-L*, Küppers R* (2018) Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells. J Clin Invest, 128, 2996-3007 (*shared senior authors)
  • Küppers R, Stevenson FK (2018) Critical influences on the pathogenesis of follicular lymphoma. Blood, 131, 2297-2306 (review)
  • Weiser C, Petkova MV, Rengstl B, Döring C, von Laer D, Hartmann S, Küppers R,  Hansmann M-L, Newrzela S (2018) Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model. Oncotarget, 9, 15942-15951
  • Küppers R (2018) CD83 in Hodgkin lymphoma. Haematologica, 103, 561-562 (Editorial)
  • Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R (2018) Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood, 131, 546-557
  • Hudnall SD, Küppers R (Editors) (2018) Precision Molecular Pathology of Hodgkin lymphoma. in: Molecular Pathology Library, Springer International Publishing, 236 pages (book)
  • Küppers R (2018) Pathogenesis and molecular genetics of Hodgkin lymphoma. in: Precision Molecular Pathology of Hodgkin Lymphoma. Eds. S.D. Hudnall & R. Küppers; Springer 35-57 (book chapter)
  • Weniger MA, Küppers R (2018) Composite lymphomas and the relationship of Hodgkin lymphoma to Non-Hodgkin lymphomas. in: Precision Molecular Pathology of Hodgkin Lymphoma. Eds. S.D. Hudnall & R. Küppers; Springer 127-155 (book chapter)
  • Lollies A, Hartmann S, Schneider M, Bracht T, Weiß A, Arnolds J, Klein-Hitpass L, Sitek B, Hansmann M-L, Küppers R*, Weniger MA* (2018) An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma. Leukemia, 32, 92-101 (*shared senior authors)
  • Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J (2018) SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia. Blood Cancer J, 8:11
  • Wein F, Weniger MA, Höing B, Arnolds J, Hüttmann A, Hansmann M-L, Hartmann S, Küppers R (2017) Complex immune evasion strategies in classical Hodgkin lymphoma. Cancer Immunol Res, 5, 1122-1132
  • Küppers R. (2017) Origin of Hodgkin lymphoma. In Hematology: Basic Principles and Practice, 7th Edition, Eds. R. Hoffman, E.J Benz, L.E. Silberstein, H.H. Heslop, J.I. Weitz, J. Anastasi. Saunders, Philadelphia, PA; chapter 74; 1204-1211 (book chapter)
  • Küppers R (2017) Hodgkin and Reed/Sternberg cells. In: Schwab M (Ed.) Encyclopedia of Cancer, 4th edition. Springer-Verlag Berlin Heidelberg, (ebook) 1-4
  • Küppers R (2017) Structure and diversification of immunoglobulin genes in African Burkitt lymphoma. Blood Advances, 1, 1259-1260 (commentary)
  • Seifert M, Küppers R (2017) Determining the origin of human germinal center B cell-derived malignancies. Meth Mol Biol, 1623, 253-279 (review)
  • Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg M-L, Sundström C, Scholtysik R*, Hansmann M-L*, Küppers R* (2017) TET2 mutations in B cells of patients affected by angioimmunoblastic T cell lymphoma. J Pathol, 242, 129-133 (*shared senior authors)
  • Herling M, Rengstl B, Scholtysik R, Hartmann S, Küppers R, Hansmann M-L, Diebner H, Roeder I, Abken H, Newrzela S, Kirberg J. (2017) Concepts in mature T-cell lymphomas – highlights from an international joint symposium on T-cell immunology and oncology. Leuk Lymphoma, 58, 788-796 (review)
  • Saeedghalati M, Farahpour F, Budeus B, Lange A, Westendorf AM, Seifert M, Küppers R, Hoffmann D (2017) Quantitative comparison of abundance structures of generalized communities: from B-cell receptor repertoires to microbiomes. PLoS Comput Biol, 13(1):e1005362
  • Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N, Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG, Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann M-L, Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M, Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A, Küppers R, Ogawa S, Stamatopoulos K, Stavroyianni N, Kanellis G, Rosenwald A, Campo E, Amini R-M, Ott G, Vassilakopoulos TP, Hummel M, Rosenquist R, Damm F. (2016) Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood, 128, 2666-2670
  • Stunnenberg HG, International Human Epigenome Consortium (228 coauthors, including Küppers R), Hirst M. (2016) The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery. Cell, 167, 1145-1149
  • Schuhmacher B, Rengstl B, Döring C, Bein J, Newrzela S, Brunnberg U, Kvasnicka HM, Vornanen M, Küppers R, Hansmann M-L, Hartmann S. (2016) A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte. Oncotarget, 7, 72197-72210
  • Johansson P, Klein-Hitpass L, Grabellus F, Arnold G, Klapper W, Pförtner R, Dührsen U, Eckstein A, Dürig J, Küppers R. (2016) Recurrent mutations in NF-kB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas. Oncotarget, 38, 62627-6239
  • Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, Claviez A, Drexler HG, Eils R, Haas S, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Leich E, Loeffler M, Mantovani-Loeffler L, López C, McHardy AC, Möller P, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Sungalee S, Szczepanowski M, Trümper L, Weniger MA, Siebert R, Borkhardt A, Hummel M, Hoell JI. (2016) Alterations of miRNAs and miRNA-regulated mRNA expression in GC B cell lymphomas determined by integrative sequencing analysis. Haematologica, 101, 1380-1389
  • Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R, for the "Molecular Mechanisms in Malignant Lymphomas" network project. (2016) Novel IGH and MYC translocation partners in diffuse large B cell lymphomas. Genes Chrom Cancer, 55, 932-943
  • Seifert M, Küppers R (2016) Human memory B cells. Leukemia, 30, 2283-2292 (review)
  • Weniger MA, Küppers R (2016) NF-kB deregulation in Hodgkin lymphoma. Semin Cancer Biol, 39, 32-39 (review)
  • Mathas S, Hartmann S, Küppers R (2016) Hodgkin lymphoma: Pathology and Biology. Semin Hematol, 53, 139-147 (review)
  • Rengstl B, Schmid F, Weiser C, Döring C, Heinrich T, Warner K, Becker PS, Wistinghausen R, Kameh-Var S, Werling E, Seidl C, Hartmann S, Abken H, Küppers R, Hansmann M-L, Newrzela S. (2016) Tumor infiltrating HLA-matched CD4+ T cells retargeted against Hodgkin and Reed-Sternberg cells. Oncoimmunol, 5, e1160186
  • Schreiber F, Kahnert S, Goehlich A, Greifendorf D, Bartels F, Janzyk U, Lennartz K, Kirstein U, Rennings A, Küppers R, Erni D (2016) Mikrofluidik-Chip-Architekturen für eine Zell-Sortieranlage basierend auf der Elektrowetting-Technologie. tm - Technisches Messen, 83, 274-288
  • Oakes CC, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert AS, Wang Q, Imbusch CD, Serva A, Koser SD, Brocks D, Lipka DB, Bogatyrova O, Weichenhan D, Brors B, Rassenti L, Kipps TJ, Mertens D, Zapatka M, Lichter P, Döhner H, Küppers R, Zenz T, Stilgenbauer S, Byrd JC, Plass C (2016) DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia. Nat Genetics, 48, 253-64
  • Küppers R. (2016) Biology of Hodgkin's lymphoma. in: Malignant Lymphomas. Biology and Molecular Pathogenesis. Eds: G. Lenz, L. Pasqualucci, De Gruyter
  • Hartmann S, Schuhmacher B, Rausch T, Fuller L, Döring C, Weniger M, Lollies A, Weiser C, Thurner L, Rengstl B, Brunnberg U, Vornanen M, Pfreundschuh M, Benes V, Küppers R, Newrzela S, Hansmann ML (2016) Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma. Leukemia, 30, 844-853
  • Wein F, Küppers R (2016) The role of T cells in the microenvironment of Hodgkin lymphoma. J Leukoc Biol, 99(1), 45-50 (review)
  • Johansson P, Bergmann A, Rahmann S, Wohlers I, Scholtysik R, Przekopowitz M, Seifert M, Tschurtschenthaler G, Webersinke G, Jäger U, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R (2016) Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. Int J Cancer, 138(1), 121-4
  • Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Hummel M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenze D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nagel I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R*, Ammerpohl O*, Lichter P*, Siebert R*, Hoffmann S*, Radlwimmer B* (2015) DNA-methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. Nat Genetics, 47(11), 1316-25 (*shared senior authors)
  • Doose G, Haake A, Bernhart SH, López C, Duggimpudi S, Wojciech F, Bergmann AK, Borkhardt A, Burkhardt B, Claviez A, Dimitrova L, Haas S, Hoell JI, Hummel M, Karsch D, Klapper W, Kleo K, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Lenze D, Loeffler M, Mantovani-Löffler L, Möller P, Ott G, Richter J, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schneider M, Scholz I, Stilgenbauer S, Stunnenberg HG, Szczepanowski M, Trümper L, Weniger MA, ICGC MMML-Seq Consortium, Hoffmann S, Siebert R, Iaccarino I (2015) MINCR is a MYC-induced lncRNA able to modulate MYC’s transcriptional network in Burkitt lymphoma cells. Proc Natl Acad Sci USA, 112, E5261-E5270
  • Budeus B, Schweigle de Reynoso S, Przekopowitz M, Hoffmann D, Seifert M*, Küppers R* (2015) The complexity of the human memory B cell compartment is determined by the versatility of clonal diversification in germinal centres. Proc Natl Acad Sci USA, 112, E5281-E5289 (*shared senior authors)
  • Wein F, Otto T, Lambertz P, Fandrey J, Hansmann M-L, Küppers R (2015) Potential role of hypoxia in early stages of Hodgkin lymphoma pathogenesis. Haematologica, 100, 1320-1326
  • Schneider M, Schneider S, Zühlke-Jenisch R, Klapper W, Sundström C, Hartmann S, Hansmann M-L, Siebert R, Küppers R, Giefing M (2015) Alterations of the CD58 gene in classical Hodgkin lymphoma. Genes Chomosomes Cancer, 54, 638-645
  • Kulis M, Merkel A, Heath S, Queirós AC, Schuyler RP, Castellano G, Beekman R, Raineri E, Esteve A, Clot G, Verdaguer-Dot N, Duran-Ferrer M, Russiñol N, Vilarrasa-Blasi R, Ecker S, Pancaldi V, Rico D, Agueda L, Blanc J, Richardson D, Clarke L, Datta A, Pascual M,  Agirre X, Prosper F, Alignani D, Paiva B, Caron G, Fest T, Muench MO, Fomin ME, Lee S-T, Wiemels JL, Valencia A, Gut M, Flicek P, Stunnenberg HG, Siebert R, Küppers R, Gut IG, Campo E, Martín-Subero JI (2015) Whole-genome fingerprint of the DNA methylome during human B-cell differentiation. Nat Genetics, 47, 746-756
  • Seifert M, Przekopowitz M, Taudien S, Lollies A, Ronge V, Drees B, Lindemann M, Hillen U, Engler H, Singer BB, Küppers R (2015) Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions. Proc Natl Acad Sci USA, 112, E546-E555
  • Przekopowitz M, Küppers R, Weniger M (2015) A large fraction of human tonsillar B cells expressing CD27 are germinal center B cells. Immunol Cell Biol, 93, 429-430 (letter)
  • Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra A, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS (2015) CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Comm, 6, 6217 (1-13)
  • Rosenwald A, Küppers R (2015) Pathology and molecular pathology of Hodgkin lymphoma. Chapter 3, p. 45-64. in Hodgkin lymphoma: a comprehensive overview. 2nd Ed., Edited by A. Engert and A. Younes. Springer Cham, Heidelberg New York, Dordrecht, London
  • Scholtysik R, Kreuz M, Hummel M, Rosolowski M, Szczepanowski M, Klapper W, Loeffler M, Trümper L, Siebert R, Küppers R (2015) Characterization of genomic imbalances in diffuse large B-cell lymphoma by detailed SNP-chip analysis. Int J Cancer, 136, 1033-1042
  • Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, SzczepanowskiM, Herrmann D, Küppers R, Pott C, Siebert R, on behalf of the HaematoSys-Project (2015) Genomic and epigenomic co-evolution in follicular lymphomas. Leukemia, 29, 456-463


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