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Publikationen der Arbeitsgruppe Molekulare Genetik (2000 - 2004)


  • Küppers R (2004) Prognosis in follicular lymphoma - it's in the microenvironment (Perspective). N. Engl. Med., 351, 2152-2153
  • Rosenquist R, Roos G, Erlanson M, Küppers R, Bräuninger A, Hansmann ML (2004) Clonally related splenic marginal zone lymphoma and Hodgkin lymphoma with unmutated V gene rearrangements and a 15-yr time gap between diagnosis. Eur. J. Haematol., 73, 210-214
  • Thomas RK, Wickenhauser C, Tawadros S, Diehl V, Küppers R, Jürgen Wolf J, Schmitz R (2004) Mutational analysis of the IkBa gene in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL). Br. J. Haematol., 126, 50-54
  • Küppers R (2004) Molecular single cell PCR analysis of rearranged immunoglobulin genes as a tool to determine the clonal composition of normal and malignant human B cells. Meth. Mol. Biol. , 271, 225-238
  • Rosenquist R, Menestrina F,Lestani M, Küppers R, Hansmann M-L, Bräuninger A (2004) Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin lymphoma. Lab. Invest., 84, 253-262
  • Küppers R, Rajewsky K (2003) Developmental and functional biology of B lymphocytes. In: Non-Hodgkin's lymphomas (Eds: P.M. Mauch, J.O. Armitage, N.L. Harris, B. Coffier, R. Dalla-Favera) Lippincott Williams & Wilkins, Baltimore
  • Falini B, Tiacci E, Pucciarini A, Bigerna B, Kurth J, Hatzivassiliou G, Droetto S, Galletti BV, Gambacorta M, Orazi A, Pasqualucci L, Miller I, Küppers R, Dalla-Favera R, Cattoretti G (2003) Expression of the IRTA1 receptor identifies intra-epithelial and sub-epithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). Blood, 102, 3684-369
  • Tinguely M, Rosenquist R, Sundström C, Amini R-M, Küppers R, Hansmann M-L, Bräuninger A (2003) Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center. Am. J. Surg. Pathol., 27, 1483-1488
  • Küppers R (2003) B cells under influence: transformation of B cells by Epstein-Barr virus. Nature Rev. Immunol. 3, 801-812
  • Bräuninger A, Spieker T, Mottok A, Baur AS, Küppers R, Hansmann M-L (2003) Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes. Eur. J. Immunol., 33, 1593-1602
  • Küppers R, Rajewsky K, Staratschek-Jox A, Wolf J, Diehl V (2003) Morbus Hodgkin. In: Molekularmedizinische Grundlagen von hämatologischen Neoplasien (Eds: Ganten, Ruckpaul) Springer Verlag, Berlin, Heidelberg, 479-494
  • Schwering I, Bräuninger A, Distler V, Jesdinsky J, Diehl V, Hansmann M-L, Rajewsky K, Küppers R (2003) Gene expression profiling of the Hodgkin's lymphoma cell line L1236 and germinal center B cells for the identification of Hodgkin's lymphoma-specific genes. Mol. Med., 9, 85-95
  • Küppers R (2003) Somatic hypermutation and B cell receptor selection in normal and transformed human B cells. In: Immune mechanisms and disease, (Eds: N. Chiorazzi et al.) Ann. N. Y. Acad. Sci., 987, 173-179
  • Kurth J, Hansmann M-L, Rajewsky K, Küppers R (2003) Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc. Natl. Acad. Sci. USA, 100, 4730-4735 (RK and KR share last authorship)
  • Bräuninger A, Wacker H-H, Rajewsky K, Küppers R, Hansmann M-L (2003) Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin´s lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin´s lymphoma. Cancer Res., 63, 1644-1651
  • Küppers R, Klein U, Schwering I, Distler V, Bräuninger A, Cattoretti G, Tu Y, Stolovitzky GA, Califano A, Hansmann M-L, Dalla-Favera R (2003) Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J. Clin. Invest., 111, 529-537 (RK, UK and IS share first authorship)
  • Schwering I, Bräuninger A, Klein U, Jungnickel B, Tinguely M, Diehl V, Hansmann M-L, Dalla-Favera R, Rajewsky K, Küppers R (2003) Loss of the B lineage-specific gene expression program in Hodgkin and Reed/Sternberg cells of Hodgkin’s lymphoma. Blood, 101, 1505-1512
  • Kurth J, Perniok A, Schmitz R, Iking-Konert C, Chiorazzi N, Thompson KM, Winkler T, Rajewsky K, Küppers R (2002) Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines. Eur.J.Immunol., 32, 2785-2792
  • Küppers R, Schwering I, Bräuninger A, Rajewsky K, Hansmann M-L (2002) Biology of Hodgkin's lymphoma. Ann. Oncol., 13, suppl. 1, 11-18
  • Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, Tucker PW, Dyer MJS, Siebert R (2002) Lack of somatic hypermutation of IG VH genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. Leukemia, 16, 937-939
  • Oeschger S, Bräuninger A, Küppers R, Hansmann M-L (2002) Tumor cell dissemination in follicular lymphoma. Blood, 99, 2192-2198
  • Müschen M, Rajewsky K, Krönke M, Küppers R (2002) The origin of CD95-gene mutations in B-cell lymphoma. Trends Immunol., 23, 75-80
  • Küppers R (2002) Molecular biology of Hodgkin's lymphoma. Adv. Cancer Res., 84, 277-312
  • Goossens T, Bräuninger A, Klein U, Küppers R. Rajewsky K (2001) Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. Eur.J. Immunol., 31, 3638-3648
  • Bräuninger A, Goossens T, Rajewsky K, Küppers R (2001) Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. Eur.J. Immunol., 31, 3631-3637
  • Küppers R, Dalla-Favera R (2001) Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene, 20, 5580-5594
  • Bräuninger A, Spieker T, Willenbrock K, Gaulard P, Wacker HH, Rajewsky K, Hansmann M-L, Küppers R (2001) Survival and clonal expansion of mutating ”forbidden” (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T cell lymphoma. J. Exp. Med., 194, 927-940
  • Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RSK, Küppers R, Dalla-Favera R (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphoma. Nature, 412, 341-346
  • Küppers R, Sousa AB, Baur AS, Strickler JG, Rajewsky K, Hansmann M-L (2001) Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin’s disease and either follicular lymphoma or B-CLL. Mol. Med., 7, 285-292 (RK und ABS share first authorships)
  • Willenbrock K, Roers A, Seidl C,Wacker HH, Küppers R, Hansmann M-L (2001) Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T-cell receptor beta gene rearrangements. Am.J.Pathol., 158, 1851-1857
  • Müschen M, Küppers R, Spieker T, Bräuninger A, Rajewsky K, Hansmann M-L (2001) Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes. Lab.Invest., 81, 289-295
  • Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann M-L, Rajewsky K (2001) Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood, 97, 818-821
  • Bräuninger A, Yang W, Wacker H-H, Rajewsky K, Küppers R, Hansman M-L (2001) B cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte predominant Hodgkin disease. Blood, 97, 714-719
  • Müschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Küppers R (2000) Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J.Exp. Med., 192, 1833-1839
  • Müschen M, Re D, Bräuninger A, Wolf J, Hansmann M-L, Diehl V, Küppers R, Rajewsky K (2000) Somatic mutations of the CD95 gene in Hodgkin- and Reed-Sternberg cells. Cancer Res., 60, 5640-5643
  • Spieker T, Kurth J, Küppers R, Rajewsky K, Bräuninger A, Hansmann M-L (2000) Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease. Blood 96, 3133-3138
  • Kurth J, Spieker T, Wustrow J, Strickler JG, Hansmann M-L, Rajewsky K, Küppers R (2000) EBV-infected B cells in infectious mononucleosis: Viral strategies for spreading in the B cell compartment and establishing latency. Immunity, 13, 485-495
  • Geiger KD, Klein U, Bräuninger A, Berger S, Leder K, Rajewsky K, Hansmann M-L, Küppers R (2000) CD5-positive B cells in healthy elderly humans are a polyclonal B cell population. Eur.J.Immunol. 30, 2918-2923
  • Roers A, Hansmann M-L, Rajewsky K, Küppers R (2000) Single cell PCR analysis of T helper cells in human lymph node germinal centers. Am. J. Pathol. 156, 1067-1071
  • Kanzler H, Küppers R, Helmes S, Wacker HH, Chott A, Hansmann ML, Rajewsky K (2000) Hodgkin and Reed-Sternberg-like cells in B cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B cell-derived clones: Potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin’s disease? Blood 95, 1023-1031
  • Jungnickel B, Staratschek-Jox A, Bräuninger A, Spieker T, Wolf J, Diehl V, Hansmann M-L, Rajewsky K, Küppers R (2000) Clonal deleterious mutations in the IB gene in the malignant cells in Hodgkin’s lymphoma. J.Exp.Med. 191, 395-401
  • Müschen M, Rajewsky K, Bräuninger A, Baur AS, Oudejans JJ, Roers A, Hansmann ML, Küppers R (2000) Rare occurrence of classical Hodgkin’s disease as a T cell lymphoma. J.Exp.Med. 191, 387-394


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