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Publikationen der Arbeitsgruppe Molekulare Genetik (1994 -1999)


  • Montesinos-Rongen M, Küppers R, Schlüter D, Spieker T, van Roost D, Schaller C, Reifenberger G, Wiestler OD, Deckert-Schlüter M (1999) Primary central nervous system lymphomas are derived from germinal center B cells and show a preferential usage of the V4-34 gene segment. Am. J. Pathol. 155, 2077-2086
  • Küppers R, Klein U, Hansmann ML, Rajewsky K (1999) Cellular origin of human B cell lymphomas. New Engl. J. Med. 341, 1520-1529
  • Montesinos-Rongen M, Roers A, Küppers R, Rajewsky K, Hansmann ML (1999) Mutations of the p53 gene are not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood 94, 1755-1760
  • Küppers R (1999) Identifying the presursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: Role of the germinal center in B cell lymphomagenesis. J. Acq. Immune Def. Syndr. 21, S74-S79
  • Jox A, Zander T, Küppers R, Irsch J, Kanzler H, Kornacker M, Bohlen H, Diehl V, Wolf J (1999) Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of Ig in the lymphoma cells. Blood 93, 3964-3972
  • Küppers R, Goossens T, Klein U (1999) The role of somatic hypermutation in the generation of deletions and duplications in human Ig V region genes and chromosomal translocations. Curr. Top. Microbiol. Immunol. 246, 193-198
  • Klein U, Rajewsky K, Küppers R (1999) Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J usage in VJ-joints and /-ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes. Curr. Top. Microbiol. Immunol. 246, 141-146
  • Bräuninger A, Hansmann ML, Strickler JG, Dummer R, Burg G, Rajewsky K, Küppers R (1999) Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and B cell Non Hodgkin's lymphoma. N. Engl. J. Med. 340, 1239-1247
  • Bräuninger A, Küppers R, Spieker T, Siebert R, Strickler JG, Schlegelberger B, Rajewsky K, Hansmann ML (1999) Molecular analysis of single B cells from T cell-rich B cell lymphoma reveals the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells. Blood 93, 2679-2687
  • Küppers R, Hansmann ML, Rajewsky K (1998) Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease. Ann.Oncol. 9, S17-S20
  • Klein U, Rajewsky K, Küppers R (1998) Human immunoglobulin (Ig) M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated V region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188, 1679-1689
  • Vockerodt M, Soares M, Kanzler H, Küppers R, Kube D, Hansmann, ML, Diehl V, Tesch H (1998) Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease. Blood 92, 2899-2907
  • Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti, RSK, Klein U, Küppers R, Rajewsky K, Dalla-Favera R (1998) BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 95, 11816-11821
  • Fischer M, Küppers R (1998) Human IgA and IgM secreting intestinal plasma cells carry heavily mutated VH region genes. Eur. J. Immunol. 28, 2971-2977
  • Irsch J, Nitsch S, Hansmann, ML, Rajewsky K, Tesch H, Diehl V, Jox A, Küppers R, Radbruch A (1998) Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues. Proc. Natl. Acad. Sci. USA 95, 10117-10122 (RK und AR share last authorships)
  • Roers A, Montesinos-Rongen M, Hansmann ML, Rajewsky K, Küppers R (1998) Amplification of TCR gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal. Eur. J.Immunol. 28, 2424-2431
  • Klein U, Goossens, T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Küppers R (1998) Somatic hypermutation in normal and transformed human B cells. Immunol.Rev. 162, 261-280
  • Küppers R, Rajewsky K (1998) The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease. Annu.Rev.Immunol. 16, 471-493
  • Jox A, Zander T, Kornacker M, Kanzler H, Küppers R, Diehl V, Wolf J (1998) Detection of identical Hodgkin-Reed Sternberg cell specific immunoglobulin gene rearrangements in a patient with Hodgkin's disease of mixed cellularity subtype at primary diagnosis and in relapse two and and a half years later. Ann.Oncol. 9, 283-287
  • Küppers R, Rajewsky K, Braeuninger A, Hansmann ML (1998) L&H cells in lymphocyte-predominant Hodgkin's disease. (Letter to the Editor). N.Engl.J.Med. 338, 763-764
  • Goossens T, Klein U, Küppers R (1998) Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc.Natl.Acad.Sci. USA 95, 2463-2468
  • Küppers R, Kanzler H, Rajewsky K, Hansmann ML (1997) Molekulare Analyse der Hodgkin- und Reed/Sternberg-Zellen des Morbus Hodgkin mittels Mikromanipulation und Einzelzell-PCR. Maligne Lymphome Hrsg. Höffkes HG, Uppenkamp M, Springer Verlag
  • Fischer M, Klein U, Küppers R (1997) Molecular single cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vgenes lacking somatic mutation. J.Clin.Invest. 100, 1667-1676
  • Braeuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML (1997) Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin's disease represent clonal populations of germinal-center derived tumor cells. Proc.Natl.Acad.Sci. USA 94, 9337-9342 (AB und RK share first authorship)
  • Küppers R, Roers A, Kanzler H (1997) Molecular single cell studies of normal and transformed lymphocytes.Cancer Surveys 30, 45-58
  • Rajewsky K, Kanzler H, Hansmann ML, Küppers R (1997) Normal and malignant B-cell development with special reference to Hodgkin's disease. Ann.Oncol. 8, S79-S81 (Suppl. 2)
  • Küppers R, Rajewsky K, Hansmann ML (1997) Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur.J.Immunol 27, 1398-1405
  • Klein U, Küppers R, Rajewsky K (1997) Evidence for a large compartment of IgM-expressing memory B cells. Blood 89, 1288-1298
  • Küppers R, Hansmann ML, Rajewsky K (1997) Micromanipulation and PCR analysis of single cells from tissue sections. Handbook of Exp. Immunol. 5th ed., Eds. D.M.Weir, C.Blackwell, L.A.Herzenberg, L.A.Herzenberg, Blackwell Scientific.
  • Kanzler H, Küppers R, Hansmann ML, Rajewsky K (1996) Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J.Exp.Med. 184, 1495-1505 (HK und RK share first authorship)
  • Hansmann ML, Küppers R (1996) Pathology and Molecular Histology of Hodgkin's disease and the border to Non-Hodgkin lymphomas. Baillieres Clin.Haematol. 9, 459-477
  • Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML (1996) Molecular Ig gene analysis reveals that monocytoid B-cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and indicates that rearrangement of the kappa deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur.J.Immunol. 26, 1794-1800
  • Küppers R, Kanzler H, Hansmann ML, Rajewsky K (1996) Single cell analysis of Hodgkin/Reed-Sternberg cells. Ann.Oncol. 7, S27-S30
  • Kanzler H, Hansmann ML, Kapp U, Wolf J, Diehl V, Rajewsky K, Küppers R (1996) Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood 87, 3429-3436
  • Küppers R, Kanzler H, Hansmann ML, Rajewsky K (1996) Immunoglobulin V genes in Reed-Sternberg cells (Letter to the Editor). N.Engl.J.Med. 334, 404
  • Küppers R, Willenbrock K, Rajewsky K, Hansmann ML (1995) Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction. Am.J.Pathol .147, 806-814
  • Franzen C, Küppers R, Müller A, Salzberger B, Fätkenheuer G, Vetten B, Diehl V, Schrappe M (1995) Genetic evidence for latent Septata intestinalis infection in human immunodeficiency virus-infected patients with intestinal microsporidiosis. J. Infect. Dis. 173, 1038-1040
  • Klein U, Klein G, Ehlin-Henriksson B, Rajewsky K, Küppers R (1995) Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes. Molec.Med. 1, 495-505
  • Küppers R, Hansmann ML, Diehl V, Rajewsky K (1995) Molecular single cell analysis of Hodgkin and Reed-Sternberg cells. Molec.Med.Today 1, 26-30
  • Ehlich A, Küppers R (1995) Analysis of immunoglobulin gene rearrangements from single B cells. Curr.Opin.Immunol. 7, 281-284
  • Küppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R, Hansmann ML (1994) Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc.Natl.Acad.Sci. USA 91, 10962-10966
  • Klein U, Küppers R, Rajewsky K (1994) Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age. J.Exp.Med. 180, 1383-1393



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