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Publikationen der Arbeitsgruppe Molekulare Genetik (2010 - 2014)


  • Montesinos-Rongen M, Purschke F, Küppers R, Deckert M (2014) Immunoglobulin repertoire of primary lymphomas of the central nervous system. J Neuropathol Exp Neurol, 73, 1116-1125
  • Kreher S, Bouhlel MA, Cauchy P, Lamprecht B, Li S, Hummel F, Köchert K, Anagnostopoulos I, Jöhrens K, Hummel M, Hiscott J, Wenzel SS, Lenz P, Schneider M, Küppers R, Scheidereit C, Giefing M, Siebert R, Rajewsky K, Lenz G, Cockerill PN, Janz M, Dörken B, Bonifer C, Mathas S (2014) Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in Hodgkin lymphoma. Proc Natl Acad Sci USA, 111, E4513-E4522
  • Döring C, Hansmann M-L, Agostinelli C, Piccaluga PP, Facchetti F, Pileri S, Küppers R, Newrzela S, Hartmann S (2014) A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK-anaplastic large cell lymphoma. Mod Pathol, 27, 1345-1354
  • Küppers R, Dührsen U, Hansmann M-L (2014) Pathogenesis, diagnosis and treatment of composite lymphomas. Lancet Oncol, 15, e435-e446. (review)
  • Küppers R (2014) A microRNA involved in the germinal center reaction. Blood, 124, 158-159 (commentary)
  • Schmidt A, Küppers R. (2014) Role of microRNAs in B cell leukemias and lymphomas. Curr Mol Med, 14, 580-597
  • Schneider M, Szaumkessel M, Richter J, Ammerpohl O, Hansmann ML, Küppers R, Siebert R, Giefing M (2014) The PRDX2 gene is transcriptionally silenced and de novo methylated in HRS cells of classical Hodgkin lymphoma. Blood, 123, 3672-3674 (letter)
  • Tucci FA, Broering R, Lutterbeck M, Schlaak JF, Küppers R (2014) Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction. Eur J Immunol, 44, 1842-1850
  • Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Küppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, Schwaenen C, Stein H, Trautmann H, Wessendorf S, Trümper L, Loeffler M, Spang R, Kluin PM, Klapper W, Siebert R. (2014) Biologic characterization of adult MYC-translocation positive mature B-cell lymphomas other than molecular Burkitt lymphoma. Haematologica, 99, 726-735
  • Tucci F, Küppers R. (2014) Role of hepatitis C virus in B cell lymphoproliferations. Virol Sinica, 29, 3-6 (perspective)
  • Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, Damm-Welk C, Drexler HG, Hummel M, Jaffe ES, Küppers R, Lefebvre C, Lisfeld J, Löffler M, Macleod RAF, Nagel I, Oschlies I, Rosolowski M, Russell RB, Rymkiewicz G, Schindler D, Schlesner M, Scholtysik R, Schwaenen C, Spang R, Szczepanowski M, Trümper L, Vater I, Wessendorf S, Klapper W, Siebert R. (2014) A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood, 123, 1187-1198
  • Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Murga Penas EM, Vater I, Jayne S, Dyer M, Schrappe M, Dührsen U, Ammerpohl O, Russell RB, Küppers R, Dürig J, Siebert R. (2014) Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Genes Chromosomes Cancer, 53, 309-316
  • Küppers R, Hartmann S, Hansmann M-L. (2014) Hodgkin lymphoma: cell of origin, immunobiology, and pathogenesis. in Knowles' Neoplastic Hematopathology Eds. A. Orazi, L.M. Weiss, K. Foucar, D.M. Knowles. Lippincott Willimas & Wilkins, Philadelphia, USA
  • Schneider S, Crescenzi B, Schneider M, Ascani S, Hartmann S, Hansmann M-L, Falini B, Mecucci C, Tiacci E, Küppers R. (2013) Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B-cell derived mantle cell lymphoma. Int J Cancer, 134, 832-843 (CM, ET and RK share last authorship)
  • Hartmann S, Döring C, Jakobus C, Rengstl B, Newrzela S, Tousseyn T, Sagaert X, Ponzoni M, Facchetti F, de Wolf-Peeters C, Steidl C, Gascoyne R, Küppers R, Hansmann M-L. (2013) Nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? PLoS One, 8, e78812
  • Rengstl B, Newrzela S, Heinrich T, Weiser C, Thalheimer FB, Schmid F, Warner K, Hartmann S, Schroeder T, Küppers R, Rieger MA, Hansmann M-L. (2013) Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells. Proc Natl Acad Sci USA, 110, 20729-20734
  • Giefing M, Winoto-Morbach S, Sosna J, Döring C, Klapper W, Küppers R, Böttcher S, Adam D, Siebert R, Schütze S. (2013) Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity. PLoS One, 8, e84928
  • Seifert M, Scholtysik R, Küppers R. (2013) Origin and pathogenesis of B cell lymphomas. Meth. Mol. Biol., 971, 1-25. (review)
  • Küppers R, Schneider M, Hansmann ML. (2013) Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells. Meth. Mol. Biol., 971, 49-63. (review)
  • Küppers R. (2013) Origin of Hodgkin lymphoma. In Hematology: Basic Principles and Practice, 6th Edition, Eds. R. Hoffman, E.J Benz, L.E. Silberstein, H.H. Heslop, J.I. Weitz, J. Anastasi. Saunders, Philadelphia, PA; chapter 73; 1130-1137. (book chapter)
  • Bohle V, Döring C, Hansmann M-L, Küppers R. (2013) Role of early B cell factor 1 (EBF1) in Hodgkin lymphoma. Leukemia, 27, 671-679
  • Tucci FA, Broering R, Johansson P, Schlaak JF, Küppers R. (2013) B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes. J Virol, 87, 2956-2962
  • Hartmann S, Tousseyn T, Döring C, Flüchter P, Hackstein H, Herreman A, Ponzoni M, de Wolf-Peeters C, Facchetti F, Gascoyne RD, Küppers R, Steidl C, Hansmann M-L. (2013) Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype. Int J Cancer, 133, 2609-2618
  • Küppers R. (2012) New insights in the biology of Hodgkin lymphoma. Hematology American Society of Hematology Education Program 2012, 328-334
  • Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RAF, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R, on behalf of the German ICGC MMML-Seq-Project. (2012) Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nature Genetics, 44, 1316-1320
  • Tiacci E, Döring C, Brune V, van Noesel CJM, Klapper W, Mechtersheimer G, Falini B, Küppers R, Hansmann M-L. (2012) Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma. Blood, 120, 4609-4620 (RK and M-LH share last authorship)
  • Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Dürig J, Küppers R. (2012) Cellular origin and pathophysiology of chronic lymphocytic leukemia. J. Exp. Med., 209, 2183-2198
  • Küppers R, Engert A, Hansmann ML (2012) Hodgkin lymphoma. J. Clin. Invest., 122, 3439-3447 (review)
  • Heuckmann JM, Balke-Want H, Malchers F, Peifer M, Sos ML, Koker M, Meder L, Lovly CM, Heukamp LC, Pao W, Küppers R, Thomas RK. (2012) Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants. Clin. Cancer Res., 18, 4682-4690
  • Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Küppers R, Lehrach H, Lengauer T, Lernmark A, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schübeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S. (2012) BLUEPRINT to decode the epigenetic signature written in blood. Nat. Biotechnol. 30, 224-226. (correspondence)
  • Scholtysik R, Nagel I, Kreuz M, Vater I, Giefing M, Schwaenen C, Wessendorf S, Trümper L, Loeffler M, Siebert R, Küppers R. (2012) Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas. Int. J. Cancer, 131, E830-E835
  • Peveling-Oberhag J, Crisman G, Schmidt A, Döring C, Lucioni M, Arcaini L, Rattotti S, Hartmann S, Piiper A, Hofmann WP, Paulli M, Küppers R, Zeuzem S, Hansmann M-L. (2012) Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection. Leukemia, 26, 1654-1662
  • Sellmann L, Carpinteiro A, Nückel H, Scholtysik R, Siemer D, Klein-Hipass L, Kube D, Dürig J, Dührsen U, Stanelle J, Küppers R. (2012) p53 protein expression in chronic lymphocytic leukemia. Leukemia Lymphoma, 53, 1282-1288
  • Otto C, Giefing M, Massow A, Vater I, Gesk S, Schlesner M, Richter J, Klapper W, Hansmann M-L, Siebert R, Küppers R. (2012) Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. Br. J. Haematol., 157, 702-708
  • Ammerpohl O, Haake A, Pellissery S, Giefing M, Richter J, Balint B, Kulis M, Le J, Bibikova M, Drexler HD, Seifert M, Shaknovic R, Korn B, Küppers R, Martín-Subero JI, Siebert R. (2011) Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes. Leukemia 26, 185-188 (letter)
  • Deckert M, Engert A, Brück W, Ferreri AJM, Finke J, Illerhaus G, Klapper W, Korfel A, Küppers R, Maarouf M, Montesinos-Rongen M, Paulus W, Schlegel U, Lassmann H, Wiestler OD, Siebert R, DeAngelis LM. (2011) Modern concepts in the biology, diagnosis, differential diagnosis, and treatment of primary central nervous system lymphoma. Leukemia, 25, 1797-1807 (review)
  • Küppers R. (2011) CCR7 & lymphotoxin in lymphoma niche. Blood, 118, 831-832 (commentary)
  • Küppers R. (2011) NPAT mutations in Hodgkin lymphoma. Blood, 118, 484-485 (commentary)
  • Küppers R. (2011) Biology of Hodgkin's lymphoma. Haematology Education, 5, 151-157 (review)
  • Salaverria I, Philipp C, Oschlies I, Kohler CW, Kreuz M, Szczepanowski M, Burkhardt B, Trautmann H, Gesk S, Andrusiewicz M, Berger H, Fey M, Harder L, Hasenclever D, Hummel M, Loeffler M, Mahn F, Martin-Guerrero I, Pellissery S, Pott C, Pfreundschuh M, Reiter A, Richter J, Rosolowski M, Schwaenen C, Stein H, Trümper L, Wessendorf S, Spang R, Küppers R, Klapper W, Siebert R, for the Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe, the German High-Grade Lymphoma Study Group and the Berlin-Frankfurt-Münster-NHL trial group. (2011) Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Blood, 118, 139-147
  • Sellmann L, de Beer D, Bartels M, Opalka B, Nückel H, Dührsen U, Dürig J, Seifert M, Siemer D, Küppers R, Baerlocher GM, Röth A. (2011) Telomeres and prognosis in patients with chronic lymphocytic leukaemia. Int. J. Hematol. 93, 74-82
  • Philipp C, Edelmann J, Bühler A, Winkler D, Stilgenbauer S, Küppers R. (2011) Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL. Int. J. Cancer, 128, 1747-1750
  • Rosenwald A, Küppers R. (2011) Pathology and molecular pathology of Hodgkin lymphoma. in Hodgkin lymphoma. Chapter 3, p. 33-48. Edited by A. Engert and S.J. Horning. Springer Verlag, Berlin Heidelberg
  • Scholtysik R, Kreuz M, Klapper W, Burkhardt B, Feller AC, Hummel M, Loeffler M, Rosolowski M, Schwaenen C, Spang R, Stein H, Thorns C, Trümper L, Vater I, Wessendorf S, Zenz T, Siebert R, Küppers R, for the "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe. (2010) Detection of genomic aberrations in molecularly defined Burkitt lymphoma by array-based high resolution single nucleotide polymorphism analysis. Haematologica, 95, 2047-2055
  • Sellmann L, Scholtysik R, Kreuz M, Cyrull S, Tiacci E, Stanelle J, Carpinteiro A, Nückel H, Boes T, Gesk S, Siebert R, Klein-Hitpass L, Dührsen U, Dürig J, Küppers R. (2010) Gene dosage effects in chronic lymphocytic leukemia. Cancer Genetics Cytogenetics, 203, 149-160
  • Stanelle J, Döring C, Hansmann M-L, Küppers R. (2010) Mechanisms of aberrant GATA-3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells. Blood, 116, 4202-4211
  • Hansmann M-L, Hartmann S, Küppers R. (2010) Hodgkin lymphoma. Chapter 34. p 143-155; in The Lymphoid Neoplasms, 3rd Edition Edited by I. Magrath, K. Bathia, P. Boffetta, C. Deardon, V. Diehl, R. Gascoyne, H.K. Müller-Hermelink, M. Potter, A.Z. Rohatiner. Hodder Education, London, UK
  • Küppers R. (2010) Overview of the immune system. Chapter 9. p. 587-607; in The Lymphoid Neoplasms, 3rd Edition; Edited by I. Magrath, K. Bathia, P. Boffetta, C. Deardon, V. Diehl, R. Gascoyne, H.K. Müller-Hermelink, M. Potter, A.Z. Rohatiner. Hodder Education, London, UK
  • Küppers R, Rosenwald A. (2010) Biologie und molekulare Pathologie des Hodgkin-Lymphoms. Krebsmedizin, 19, 110-116 (Review)
  • Montesinos-Rongen M, Schmitz R, Brunn A, Gesk S, Richter J, Hong K, Wiestler OD, Siebert R, Küppers R, Deckert M. (2010) Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma. Acta Neuropathol., 120, 529-535
  • Schmidt A, Schmitz R, Giefing M, Martin-Subero JI, Gesk S, Vater I, Massow A, Maggio E, Schneider M, Hansmann M-L, Siebert R, Küppers R. (2010) Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma, Genes Chrom. Cancer, 48, 803-809
  • Küppers R. (2010) Genomic imbalances in Hodgkin lymphoma. Blood, 116, 309-311 (Commentary)
  • Nückel H, Switala M, Sellmann L, Horn PA, Dürig J, Dührsen U, Küppers R, Grosse-Wilde H, Rebmann V. (2010) The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia, 24, 1152-1159
  • Küppers R. (2010) Side population cells in Hodgkin lymphoma. Leukemia Lymphoma, 51,741-742 (Commentary)
  • Müller C, Siemer D, Lehnerdt G, Lang S, Küppers R. (2010) Molecular analysis of IgD-positive human germinal centres. Int. Immunol., 22, 289-298
  • Rosenwald A, Küppers R. (2010) Pathologie und molekulare Pathologie des Hodgkin-Lymphoms. Der Onkologe, 16, 9-17
  • Hartmann S, Gesk S, Scholtysik R, Kreuz M, Bug S, Vater I, Döring C, Cogliatti S, Parrens M, Merlio J-P, Kwiecinska A, Porwit A, Piccaluga PP, Pileri P, Hoefler G, Küppers R, Siebert R, Hansmann M-L. (2010) High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus. Br. J. Haematol., 148, 402-412
  • Schumacher MA, Schmitz R, Brune V, Tiacci E, Döring C, Hansmann M-L, Siebert R, Küppers R. (2010) Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma. Haematologica, 95, 153-157
  • Küppers R. (2010) Developmental and functional biology of B lymphocytes. In: Non-Hodgkin lymphomas; 2nd ed. (Eds: J.O. Armitage, P.M. Mauch, N.L. Harris, B. Coffier, R. Dalla-Favera) Lippincott Williams & Wilkins, Philadelphia
  • Zenz T, Mertens D, Küppers R, Döhner H, Stilgenbauer S. (2010) From pathogenesis to treatment of chronic lymphocytic leukaemia. Nature Rev. Cancer, 10, 37-50

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