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Publikationen der Arbeitsgruppe Molekulare Genetik (2005 - 2009)


  • Schmitz R, Hansmann M-L, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R (2009) TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J. Exp. Med., 206, 981-989
  • Martín-Subero JI, Kreuz M, Bibikova M, Bentink S, Ammerpohl O, Wickham-Garcia E, Rosolowski M, Richter J, Lopez-Serra L, Ballestar E, Berger H, Agirre X, Bernd H-W, Calvanese V, Cogliatti SB, Drexler HG, Fan J-B, Fraga M-F, Hansmann M-L, Hummel M, Klapper W, Korn B, Küppers R, MacLeod RA, Möller P, Ott G, Pott C, Prosper F, Rosenwald A, Schwaenen C, Schübeler D, Seifert M, Stürzenhofecker B, Weber M, Wessendorf S, Loeffler M, Trümper L, Stein H, Spang R, Esteller M, Barker D, Hasenclever D, Siebert R. (2009) New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic and transcriptional profiling. Blood, 113, 2488-2497
  • Küppers R (2009) Biology of Hodgkin lymphoma. Nature Rev. Cancer, 9, 15-27
  • Schmitz R, Stanelle J, Hansmann M-L, Küppers R. (2009) Pathogenesis of classical and lymphocyte predominant Hodgkin lymphoma. Annu. Rev. Pathol., 4, 151-174
  • Seifert M, Steimle-Grauer SA, Goossens T, Hansmann M-L, Bräuninger A, Küppers R. (2009) A model for the development of human IgD-only B cells: genotypic analyses suggest their generation in superantigen driven immune responses. Mol. Immunol., 46, 630-639
  • Brune V, Tiacci E, Pfeil I, Döring C, Eckerle S, van Noesel CJM, Klapper W, Falini B, von Heydebreck A, Metzler D, Bräuninger A, Hansmann M-L, Küppers R. (2008) Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis. J. Exp. Med., 205, 2251-2268
  • Küppers R. (2008) Memory B cells of a special kind. Immunol. Cell Biol., 86, 635-636 (News and Commentary
  • Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R. (2008) BCL2 and BCL3 are recurrent translocation partners of the IGH locus in classical Hodgkin lymphoma. Cancer Genetics Cytogenetics, 186, 110-114
  • Tiacci E, Brune V, Küppers R. (2008) Aspects of gene expression in B cell lymphomas. In: Microarrays in inflammation (Series: Progress in Inflammation Research) Editors: Bosio, A, Gerstmayer, B. Birkhäuser-Verlag, Basel, Switzerland
  • Hartmann S, Martin-Subero JI, Gesk S, Hüsken J, Giefing M, Nagel I, Riemke J, Chott A, Klapper W, Parrens M, Küppers R, Bräuninger A, Siebert R, Hansmann ML. (2008) Detection of genomic imbalances in microdissected Hodgkin- and Reed-Sternberg cells of classical Hodgkin lymphoma by array based comparative genomic hybridization. Haematologica, 93, 1318-1326
  • Giefing M, Arnemann J, Martin-Subero JI, Nieländer I, Bug S, Hartmann S, Arnold N, Tiacci E, Frank M, Hansmann ML, Küppers R, Siebert R. (2008) Identification of candidate tumor suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterization of homozygous deletions in classical Hodgkin lymphoma cell lines. Br. J. Haematol., 142, 916-924
  • Courts C, Montesinos-Rongen M, Brunn A, Bug S, Siemer D, Hans V, Blümcke I, Klapper W, Schaller C, Wiestler OD, Küppers R, Siebert R, Deckert M. (2008) Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma. J. Neuropathol. Exp. Neurol., 67, 720-727
  • Gleissner B, Küppers R, Siebert R, Glass B, Trümper L, Hiddemann W, Dreyling M. (2008) Report of a workshop on malignant lymphoma: a review of molecular and clinical risk profiling. Br. J. Haematol., 142, 176-178
  • Siemer D, Kurth J, Lang S, Lehnerdt G, Stanelle J, Küppers R. (2008) EBV transformation overrides gene expression patterns of B cell differentiation stages. Mol. Immunol., 45, 3133-3141
  • Röck J, Schneider E, Grün JR, Grützkau A, Küppers R, Schmitz J, Winkels G. (2007) CD303 (BDCA-2) signals in plasmacytoid dendritic cells by a BCR-like signalosome involving Syk, Slp65 and PLC2. Eur. J. Immunol., 37, 3564-3575
  • Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martín-Subero JI, Schroers R, Siemer D, Nückel H, Dyer MJS, Dührsen U, Siebert R, Dürig J, Küppers R. (2007) Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukemia. Br. J. Haematol., 138, 217-220
  • Renné C, Minner S, Küppers R, Hansmann M-L, Bräuninger A. (2008) Autocrine NGF/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines. Leuk. Res., 32, 163-167
  • Maggio E, Benharroch D, Gopas J, Dittmer U, Hansmann M-L, Küppers R (2007) Absence of measles virus genome and transcripts in Hodgkin-Reed/Sternberg cells of a cohort of Hodgkin lymphoma patients. Int. J. Cancer, 121, 448-453
  • Küppers R, Re D (2007) Nature of Reed-Sternberg and L&H cells, and their molecular biology in Hodgkin lymphoma. In: Hoppe RT, Armitage JO, Diehl V, Mauch PM, Weiss LM (eds) Hodgkin lymphoma. Lippincott Williams & Wilkins, Philadelphia, 2nd ed., p.73-86
  • Renné C, Willenbrock K, Martin-Subero JI, Hinsch N, Döring C, Tiacci E, Klapper W, Möller P, Küppers R, Hansmann M-L, Siebert R, Bräuninger A (2007) High expression of several tyrosine kinases and activiation of P13K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma. Leukemia, 21, 780-787
  • Courts C, Montesinos-Rongen M, Martin-Subero JI, Brunn A, Siemer D, Zühlke-Jenisch R, Pels H, Jürgens A, Schlegel U, Schmidt-Wolf IGH, Schaller C, Reifenberger G, Sabel M, Warnecke-Eberz U, Wiestler OD, Küppers R, Siebert R, Deckert M (2007) Transcriptional profiling of the NF-KB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression. J. Neuropathol. Exp. Neurol., 66, 230-237
  • Renné C, Hinsch N, Willenbrock K, Fuchs M, Klapper W, Engert A, Küppers R, Hansmann M-L, Bräuninger A (2007) The aberrant expression of several receptor tyrosine kinase is largely restricted to EBV-negative cases of classical Hodgkin lymphoma. Int. J. Cancer, 120, 2504-2509
  • Kluiver J, Kok K, Pfeil I, de Jong D, Blokzijl T, Harms G, van der Vlies P, Diepstra A, Atayar C, Poppema S, Küppers R, van den Berg A (2007) Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma. Hematol. Oncol., 25, 21-29
  • Martin-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Distler V, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TFE, Berger F, Bernd H-W, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann M-L, Siebert R (2006) Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Cancer Res., 66, 10332-10338
  • Frey UH, Nückel H, Sellmann L, Bechtel D, Küppers R, Dürig J, Dührsen U, Siffert W (2006) The GNAS1 T393C polymorphism is assiociated with disease progression and survival in chronic lymphocytic leukemia. Clin. Cancer Res., 12, 5686-5692
  • Renné C, Martin-Subero JI, Eickernjäger M, Hansmann M-L, Küppers R, Siebert R, Bräuninger A (2006) Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am. J. Pathol., 169, 655-664
  • Küppers R, Tiacci E (2006) Lymphoma. In: Encyclopedia of Respiratory Medicine. Vol 4, Editors: Geoffrey J. Laurent and Steven D. Shapiro. Academic Press, London, UK, 344-349
  • Schmitz R, Thomas RK, Harttrampf AC, Wickenhauser C, Schultze JL, Hansmann M-L, Wolf J, Küppers R (2006) The major subtypes of human B cell lymphomas lack mutations in BCL-2 family member BAD. Int. J. Cancer, 119, 1738-1740
  • Küppers R, Bräuninger A (2006) Reprogramming of tumour B cell phenotypes in Hodgkin lymphoma. Trends Immunol., 27, 203-205
  • Willenbrock K, Küppers R, Renné C, Brune V, Eckerle S, Weidmann E, Bräuninger A, Hansmann M-L (2006) Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin lymphoma. Haematologica/The Hematology Journal, 91, 596-604
  • Bräuninger A, Schmitz R, Bechtel D, Renné C, Hansmann M-L, Küppers R (2006) Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. Int. J. Cancer, 118, 1853-1861
  • Küppers R, Yahalom J, Josting A (2006) Advances in biology, diagnostics and treatment of Hodgkin's disease. Biol. Blood Marrow Transpl., 12 (Suppl., 1), 66-76
  • Bechtel D, Kurth J, Unkel C, Küppers R (2005) Transformation of BCR-deficient germinal center B Cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and post transplant lymphoma. Blood, 106, 4345-4350
  • Willenbrock K, Jungnickel B, Hansmann M-L, Küpper R (2005) Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase (AID). Eur. J. Immunol., 35, 3002-3007
  • Re D, Küppers R, Diehl V (2005) Molecular pathogenesis of Hodgkin's lymphoma. J. Clin. Oncol., 23, 6379-6386
  • Küppers R (2005) Biology of Hodgkin's lymphoma. Haematology (Eur. Hematol. Assos. Edu. Programme), 1, 167-171
  • Schmitz R, Renné C, Rosenquist R, Tinguely M, Distler V, Menestrina F, Lestani M, Stankovic T, Austen B, Bräuninger A, Hansmann M-L, Küppers R (2005) Insight into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin and non-Hodgkin lymphomas. Leukemia, 19, 1452-1458
  • Thomas RK, Schmitz R, Harttrampf AC, Hadi AA, Winckenhauser C, Distler V, Hansmann M-L, Schultze JL, Küppers R, Wolf J (2005) Apoptosis-resistant phenotype of classical Hodgkin's lymphoma is not mediated by somatic mutations within the genes encoding for members of the death-inducing signaling complex (DISC). Leukemia, 19, 1079-1082
  • Küppers R, Schmitz R, Distler V, Renné C, Bräuninger A, Hansmann M-L (2005) Pathogenesis of Hodgkin's lymphoma. Eur. J. Haematol., 75 (Suppl. 66), 26-33
  • Montesinos-Rongen M, Schmitz R, Stenzel W, Courts C, Bechtel D, Niedobitek G, Blümcke I, Reifenberger G, von Deimling A, Jungnickel B, Wiestler OD, Küppers R, Deckert M (2005) Absence of immunoglobulin class switch in primary lymphomas of the central nervous system. Am. J. Pathol., 166, 1773-1779
  • Renné C, Willenbrock K, Küppers R, Hansmann M-L, Bräuninger A (2005) Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma. Blood, 105, 4051-4059
  • Küppers R (2005) Mechanisms of B cell lymphoma pathogenesis. Nature Rev. Cancer, 5, 251-262
  • Küppers R, Hansmann M-L (2005) The Hodgkin and Reed-Sternberg cell. Int. J. Biochem. Cell Biol., 37, 511-517



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