Publikationen


2017

Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P:  Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells. EMBO Rep. 2017 Dec;18(12):2144-2159. doi: 10.15252/embr.201744121. Epub 2017 Nov 2.

Krieg SM, Voigt F, Knuefermann P, Kirschning CJ, Plesnila N, Ringel F.: Decreased Secondary Lesion Growth and Attenuated Immune Response after Traumatic Brain Injury in Tlr2/4-/- Mice. Front Neurol. 2017 Aug 30;8:455. doi: 10.3389/fneur.2017.00455. eCollection 2017.

Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G: Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.  Front Cell Infect Microbiol. 2017 Aug 8;7:359. doi: 10.3389/fcimb.2017.00359. eCollection 2017.

Ma Z, Liu J, Wu W, Zhang E, Zhang X, Li Q, Zelinskyy G, Buer J, Dittmer U, Kirschning CJ, Lu M: The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model.  Cell Mol Immunol. 2017 Dec;14(12):997-1008. doi: 10.1038/cmi.2017.43. Epub 2017 Jul 31.

Schick J, Etschel P, Bailo R, Ott L, Bhatt A, Lepenies B, Kirschning C, Burkovski A, Lang R: Toll-Like Receptor 2 and Mincle Cooperatively Sense Corynebacterial Cell Wall Glycolipids.Infect Immun. 2017 Jun 20;85(7). pii: e00075-17. doi: 10.1128/IAI.00075-17. Print 2017 Jul.

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S: Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017 Mar 16;8:14600. doi: 10.1038/ncomms14600.

2016

Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA:  RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production. Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8.

Stein K, Brand S, Jenckel A, Sigmund A, Chen ZJ, Kirschning CJ, Kauth M, Heine H: Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects. J Allergy Clin Immunol. 2017 Feb;139(2):667-678.e5. doi: 10.1016/j.jaci.2016.06.018. Epub 2016 Jul 15.

Lehmann MH, Torres-Domínguez LE, Price PJ, Brandmüller C, Kirschning CJ, Sutter G:  CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection. J Leukoc Biol. 2016 Jun;99(6):1057-64. doi: 10.1189/jlb.4MA0815-376RR. Epub 2016 Mar 18. Review.

 

2015

 

Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2. Christina Fieber, Marton Janos, Tina Koestler, Nina Gratz, Xiao-Dong-Li, Virginia Castiglia, Marion Aberle, Martina Sauert, Mareike Wegner, Lena Alexopoulou, Carsten J. Kirschning, Zhijian J. Chen, Arndt von Haeseler and Pavel Kovarik. PLoS One, Accepted.

 

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Khairnar 1, Duhan V, Maney Sk,Honke N, Shaabani N, Pandyra AA, Seifert M4, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R,  Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. Nat. Commun. 2015 Feb 18; 6:6217. doi: 10.1038/ncomms7217

 

 

2014

 

Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection. Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J, Westendorf AM. Nanomedicine. 2014 Nov; 10(8): 1787-98. doi: 10.1016/j.nano.2014.06.014. Epub 2014 Jul 9.

 

Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccina virus Ankara. Price PJ, Luckow B, Torres-Domínguez LE, Brandmüller C, Zorn J, Kirschning CJ, Sutter G, Lehmann MH, J Virol. 2014 Sep; 88 (18): 10840-50. doi:10.1128/JVI.01524-14. Epub 2014 Jul 9.

 

Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice. Dankmeyer JL, Fast RL, Cote CK, Worsham PL, Fritz D, Fisher D, Kern SJ, Merkel T, Kirschning CJ, Amemiya K. J Immunol Res. 2014; 2014: 341820. doi: 10.1155/2014/341820. Epub 2014 Jun 4.

 

 

2013

 

TLR-indepentent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geogrpahoc atrophy. Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J. Invest Ophtalmol Vis Sci. 2013 Nov 11; 53(12):7395-401. doi: 10.1167/iovs.13-12500.

 

Molecular cloning and characterization of a novel anti-TLR9 intrabody. Reimer E, Somplatzki S, Zegenhagen D, Hänel S, Fels A, Bollhorst T, Hovest LG, Bauer S, Kirschning CJ, Böldicke T. Cell Mo Biol Lett. 2013 Sep; 18(3):433-46. doi: 10.2478/s11658-013-0098-8. Epub 2013 Jul 26.

 

Nanopathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells. Volz T, Skabytska Y, Guenova E, Chen KM, Frick JS, Kirschning CJ, Kaesler S, Röcken M, Biedermann T. J Invest Dermatol. 2014 Jan; 134(1):96-104. doi: 10.1038/jid.2013.291. Epub 2013 Jun 28.

 

Bacteria evade immune recognition via TLR13 and binding of their 23S rRNA by MLS antibiotics by the same mechanisms. Hochrein H, Kirschning CJ. Oncoimmunology. 2013 Mar 1; 2(3):e23141.

 

Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus. Muntasell A, Costa-Garcia M, Vera A, Marina-Garcia N, Kirschning CJ, López-Botet M. Front Immunol. 2013 Feb 21; 4:40. doi: 10.3389/fimmu.2013.00040. eCollection 2013. 

 

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling. Desl Cm Werninhaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger EM, Prazeres da Costa C, Lang R. PLoS One. 2013;8(1):e53531. doi: 10.1371/journal.pone.0053531. Epub 2013 Jan 7.

 

 

2012

 

Gamrekelashvili J, Ormandy LA, Heimesaat MM, Kirschning CJ, Manns MP, Korangy F, Greten TF. Primary sterile nectrotic cells fail to cross-prime CD8(+) T cells. Oncoimmunology. 2012 Oct 1;1(7):1017-1026.


M. Oldenburg, A. Krüger, R. Ferstl, A. Kaufmann, G. Nees, A. Sigmund, B. Bathke, H. Lauterbach, M. Suter, S. Dreher, U. Koedel, S. Akira, T. Kawai, J. Buer, H. Wagner, S. Bauer, H. Hochrein, CJ. Kirschning. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science 2012;337(6098):1111.

Abstract: http://www.sciencemag.org/cgi/content/abstract/science.1220363?ijkey=n5U/vyzmlM/Oo&keytype=ref&siteid=sci 

Article: http://f1000.com/717956176?bd=1

Reprint: http://www.sciencemag.org/cgi/rapidpdf/science.1220363?ijkey=n5U/vyzmlM/Oo&keytype=ref&siteid=sci

 

SC. Ganal, SL. Sanos, C. Kallfass, K. Oberle, C. Johner, C. Kirschning, S. Lienenklaus, S. Weiss, P. Staeheli, P. Aichele, A. Diefenbach. Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota. Immunity. [Epub ahead of print] 2012.

 

S. Tchaptchet, M. Gumenscheimer, C. Kalis, N. Freudenberg, C. Hölscher, CJ. Kirschning, M. Lamers, C. Galanos, MA. Freudenberg. TLR9-Dependent and Independent Pathways Drive Activation of the Immune System by Propionibacterium Acnes. PLoS One. 7:e39155, 2012.

 

T. Eigenbrod, L. Franchi, R. Muñoz-Planillo, CJ. Kirschning, MA. Freudenberg, G. Núñez, A. Dalpke. Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B. J Immunol. [Epub ahead of print], 2012.

 

I. Bekeredjian-Ding, S. Foermer, CJ. Kirschning, M. Parcina, K. Heeg. Poke weed mitogen requires Toll-like receptor ligands for proliferative activity in human and murine B lymphocytes. PLoS One. 7(1):e29806, 2012.

 

PJ. Hanley, M. Kronlage, C. Kirschning, A. del Rey, F. Di Virgilio, J. Leipziger, IP. Chessell, S. Sargin, MA. Filippov, O. Lindemann, S. Mohr, V. Königs, H. Schillers, M. Bähler, A. Schwab. Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. J Biol Chem. 287(13):10650-63, 2012.

 

J. Welsch, T. Hübschle, J. Murgott, C. Kirschning, C. Rummel, R. Gerstberger, J. Roth. Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36. Innate Immun. 18(3):541-59, 2012.

 

2011

 

T. Schwandt, B. Schumak, GH. Gielen, F. Jüngerkes, P. Schmidbauer, K. Klocke, A. Staratschek-Jox, N. van Rooijen, G. Kraal, I. Ludwig-Portugall, L. Franken, S. Wehner, JC. Kalff, O. Weber, C. Kirschning, C. Coch, U. Kalinke, J. Wenzel, C. Kurts, R. Zawatzky, B. Holzmann, L. Layland, JL. Schultze, S. Burgdorf, JM. den Haan, PA. Knolle, A. Limmer. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J. 31(1):201-13, 2011.

 

T. Hoegen, N. Tremel, M. Klein, B. Angele, H. Wagner, C. Kirschning, HW. Pfister, A. Fontana, S. Hammerschmidt, U. Koedel. The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. J Immunol. 187(10):5440-51, 2011.

 

J. Lippmann, HC. Müller, J. Naujoks, C. Tabeling, S. Shin, M. Witzenrath, K. Hellwig, CJ. Kirschning, GA. Taylor, W. Barchet, S. Bauer, N. Suttorp, CR. Roy, B. Opitz. Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. Cell Microbiol. 13(11):1668-82, 2011.

 

S. Specht, J.K. Frank, J. Alferink, B. Dubben, L.E. Layland, G. Denece, O. Bain, I. Förster, C.J. Kirschning, C. Martin, A. Hoerauf. CCL17 Controls Mast Cells for the Defense against Filarial Larval Entry. J Immunol. 186(8):4845-52, 2011.

 

K. Yakimchuk, C. Roura-Mir, K.G. Magalhaes, A. de Jong, A.G. Kasmar, S.R. Granter, R. Budd, A. Steere, V. Pena-Cruz, C. Kirschning, T.Y. Cheng, D.B. Moody. Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β. Eur J Immunol. 41(3):694-705, 2011.

 

J. Mersmann, K. Habeck, K. Latsch, R. Zimmermann, C. Jacoby, J.W. Fischer, C. Hartmann, J. Schrader, C.J. Kirschning, K. Zacharowski. Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation. Basic Res Cardiol. 106:89-98, 2011.

 

2010

 

K. Gibbert, K.K. Dietze, G. Zelinskyy, K.S. Lang, W. Barchet, C.J. Kirschning, U. Dittmer. Polyinosinic-polycytidylic Acid treatment of friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol. 185:6179-89, 2010.

 

J. Mersmann, A. Koch, N. Tran, R. Zimmermann, T.F. Granja, J. Larmann, C. Herzog, G. Theilmeier, S.R. Bornstein, C.J. Kirschning, K. Zacharowski. Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion. Crit Care Med. 38(10):1927-32, 2010.

 

M. Baiersdörfer, M. Schwarz, K. Seehafer, C. Lehmann, A. Heit, H. Wagner, C.J. Kirschning, C. Koch-Brandt. Toll-like receptor 3 mediates expression of clusterin/apolipoprotein J in vascular smooth muscle cells stimulated with RNA released from necrotic cells. Exp Cell Res. 2010 

 

C.J. Kirschning, S. Dreher, B. Maass, S. Fichte, J. Schade, M. Köster, A. Noack, W. Lindenmaier, H. Wagner, T. Böldicke. Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation. BMC Biotechnol. 10:31, 2010.

 

K. Rusai, D. Sollinger, M. Baumann, B. Wagner, M. Strobl, C. Schmaderer, M. Roos, C. Kirschning, U. Heemann, J. Lutz. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Pediatr Nephrol. 25(5):853-60, 2010.

 

S. Wang, C. Schmaderer, E. Kiss, C. Schmidt, M. Bonrouhi,S. Porubsky, N. Gretz, L. Schaefer, C.J. Kirschning, Z.V. Popovic, H.-J. Gröne (Heidelberg). Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88 and TRIF dependent signaling. Disease Models & Mechanisms. 3(1-2):92-103, 2010.

 

2009

 

M.L. Conrad, F. Ferstl, R. Teich, S. Brand, N. Blümer, A.Ö. Yildirim, C.C. Patrascan, A. Hanuszkiewicz, S. Akira, H. Wagner, O. Holst, E. von Mutius, P.I. Pfefferle, C.J. Kirschning, H. Garn, H. Renz.  Maternal TLR signaling is required for prenatal asthma protection by the non-pathogenic microbe Acinetobacter lwoffii F78. J Exp Med. 206(13):2869-77, 2009.

 

W.G. Bessler, K. Puce , U. vor dem Esche, C. Kirschning, M. Huber. Immunomodulating effects of OM-89, a bacterial extract from Escherichia coli, in murine and human leukocytes. Arzneimittelforschung. 59(11):571-7, 2009.

 

M. Hösel, M. Quasdorff, K. Wiegmann, D. Webb, U. Zedler, M. Broxtermann, R. Tedjokusumo, K. Esser, S. Arzberger, CJ. Kirschning, A. Langenkamp, C. Falk, H. Büning, S. Rose-John, U. Protzer. Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology. 50(6):1773-82, 2009.

 

C.A. Andersen, I. Rosenkrands, A.W. Olsen, P. Nordly, D. Christensen, R. Lang, C. Kirschning, J.M. Gomes, V. Bhowruth, D.E. Minnikin, G.S. Besra, F. Follmann, P. Andersen, E.M. Agger. Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin. J Immunol. 183(4):2294-302, 2009.

 

S. Siegemund, A. Hartl, H. von Buttlar, F. Dautel, R. Raue, MA. Freudenberg, G. Fejer, M. Büttner, G. Köhler, CJ. Kirschning, T. Sparwasser, G. Alber. Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. Virol. 83(18):9411-22, 2009.

 

R. Rad, W. Ballhorn, P. Voland, K. Eisenächer, J. Mages, L. Rad, R. Ferstl, R. Lang, H. Wagner, R.M. Schmid, S. Bauer, C. Prinz, C.J. Kirschning, A. Krug. Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology. 136(7):2247-57, 2009.

 

M.S. Kormann, R. Ferstl, M. Depner, N. Klopp, S. Spiller, T. Illig, C. Vogelberg, E. von Mutius, C.J. Kirschning, M. Kabesch. Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk. Allergy. 64(4):636-42, 2009.

 

L. Schädlich, T. Senger, C.J. Kirschning, M. Müller, L. Gissmann. Refining HPV 16 L1 purification from E. coli: reducing endotoxin contaminations and their impact on immunogenicity. Vaccine. 27(10):1511-22, 2009.

 

A. Babiak, K. Werninghaus, O. Groß, C. Hölscher, H. Dietrich, E. M. Agger, J. Mages, A. Mocsai, C.J. Kirschning, A. Heit, P. Andersen, H. Wagner, J. Ruland, R. Lang. Adjuvanticity of a synthetic cord factor analog for subunit M. tuberculosis vaccination requires Fcrgamma-Syk-Card9-dependent innate immune activation. J Exp Med. 206(1):89-97, 2009.

 

 

Buchbeiträge:

R. Ferstl, S. Spiller, S. Fichte, S. Dreher, C.J. Kirschning. Experimental models of acute infection and Toll-like receptor driven septic shock. Methods Mol Biol. 2009;517:313-27 in 'Toll-like receptors' (McCoy, C.E and O'Neill, L.A.J., ed.) Humana, Totowa, NJ.