Publikationen:


2023

 

Abberger H, Hose M, Ninnemann A, Menne C, Eilbrecht M, Lang KS, Matuschewski K, Geffers R, Herz J, Buer J, Westendorf AM, Hansen W (2023). Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections. PLoS Pathogens 2023 Nov 29;19(11):e1011837. doi: 10.1371/journal.ppat.1011837

 

 

2022

 

Podschwadt P, Malyshkina A, Windmann S, Papadamakis A, Kerkmann L, Lapuente D, Tenbusch M, Lu M, Schindler M, Lang KS, Hansen W and Bayer W (2022) Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin 10-producing CD4+ T cells. Front. Immunol. 13:934399. doi: 10.3389/fimmu.2022.934399.

 

Podschwadt P, Malyshkina A, Windmann S, Werner T, Hansen W, Bayer W. A detailed analysis of F-MuLV- and SFFV-infected cells in Friend virus-infected mice reveals the contribution of both F-MuLV- and SFFV-infected cells to the interleukin-10 host response. Retrovirology. 2022 Dec 16;19(1):29. doi: 10.1186/s12977-022-00613-4. PMID: 36527061; PMCID: PMC9758943.

 

Wilk C, Effenberg L, Abberger H, Steenpass L, Hansen W, Zeschnigk M, Kirschning C, Buer J, Kehrmann J. CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells. Cell Immunol. 2022 Jan;371:104471. doi: 10.1016/j.cellimm.2021.104471. Epub 2021 Dec 20. PMID: 34954490.

 

Beckmann L, Obst S, Labusek N, Abberger H, Köster C, Klein-Hitpass L, Schumann S, Kleinschnitz C, Hermann DM, Felderhoff-Müser U, Bendix I, Hansen W, Herz J. Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury. Stroke. 2022 Feb;53(2):381-390. doi: 10.1161/STROKEAHA.121.037537. Epub 2022 Jan 5. PMID: 34983246; PMCID: PMC8785522.

 

Hose M, Günther A, Naser E, Schumacher F, Schönberger T, Falkenstein J, Papadamakis A, Kleuser B, Becker KA, Gulbins E, Haimovitz-Friedman A, Buer J, Westendorf AM, Hansen W. Cell-intrinsic ceramides determine T cell function during melanoma progression.Elife. 2022 Nov 25;11:e83073. doi: 10.7554/eLife.83073.

 

Günther A, Hose M, Abberger H, Schumacher F, Veith Y, Kleuser B, Matuschewski K, Lang KS, Gulbins E, Buer J, Westendorf AM , Hansen W. The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by reulating erythropoiesis, Elife. 2022 Sep 12;11:e77975. doi: 10.7554/eLife.77975.

 

Pylaeva E, Korschunow G, Spyra I, Bordbari S, Siakaeva E, Ozel I, Domnich M, Squire A, Hasenberg A, Thangavelu K, Hussain T, Goertz M, Lang KS, Gunzer M, Hansen W, Buer J, Bankfalvi A, Lang S, Jablonska J. During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes. Cell Reports. 2022, 40: 111171. 

 

Philipp S, Horstmann M, Hose M, Daser A, Görtz GE, Jesenek C, Flögel U, Hansen W, Bechrakis N, Banga JPS, Eckstein A, Berchner-Pfannschmidt U. An early wave of macrophage infiltration intertwined with antigen specific proinflammatory T-cells and browning of adipose tissue characterizes the onset of orbital inflammation in a mouse model of Graves' orbitopathy. Thyroid. 2022,32(3): 293. 

 

 

Beckmann L, Obst S, Labusek N, Abberger H, Köster C, Klein-Hitpass L, Schumann S, Kleinschnitz C, Hermann DM, Felderhoff-Müser U, Bendix I, Hansen W, Herz J. Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury. Stroke 2022, 53(2):381-390.

 

Wilk C, Effenberg L, Abberger H, Steenpass L, Hansen W, Zeschnigk M, Kirschning C, Buer J, Kehrmann J. CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells. Cell Immunol. 2022, 371: 104471.

 

 

2021

 

Abberger H, Barthel R, Bahr J, Thiel J, Luppus S, Buer J, Westendorf AM, Hansen W. Neuropilin-1 Is Expressed on Highly Activated CD4+ Effector T Cells and Dysfunctional CD4+ Conventional T Cells from Naive Mice. J Immunol. 2021 Sep 1;207(5):1288-1297. doi: 10.4049/jimmunol.2100222. Epub 2021 Aug 2. PMID: 34341169..

 

Ngo Thi Phuong N, Palmieri V, Adamczyk A, Klopfleisch R, Langhorst J, Hansen W, Westendorf AM, Pastille E.  IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Accute Colitis.  Front Immunol. 2021 12:669787.


Budeus B, Kibler A, Brauser M, Homp E, Bronichewski K, Ross AJ, Görgens A, Weniger MA, Dunst J, Kreslavsky T, Vitoriano da Conceicao Castro S, Murke F, Oakes CC, Rusch P, Andrikos D, Kern P, Köninger A, Lindemann M, Johansson P, Hansen W, Lundell A-C, Rudin A, Dürig J, Giebel B, Hoffmann D, Küppers R, Seifert M (2021) Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved lg Repertoires and Accelerated Response Dynamics. J Immunol 2021; 206 (12): 2839-51.
 

 

Adamczyk A, Pastille E, Kehrmann J, Vu VP, Geffers R, Wasmer MH, Kasper S, Schuler M, Lange CM, Mgugli B, Rau TT, Klein D, Hansen W, Krebs P, Buer J, Westendorf AM. GPR15 facilitates Recruitment of Regulatory T cells to Promote Colorectal Cancer. Cancer Res. 2021; 81(11):2970-2982.

 

Palmieri V, Ebel JF, Ngo Thi Phuong N, Klopfleisch R, Vu VP, Adamczyk A, Zöller J, Riedel C, Buer J, Krebs P, Hansen W, Pastille E, Westendorf AM. Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity.  Mucosal Immunol. 2021; 14 (4): 923-36.

2020

 

Hansen W, Luppus S, Barthel R, Chang DI, Broemstrup J, Zwarg T, Shibata, Westendorf AM, Buer J, Scherbaum N. Heroin-assisted treatment of heroin-addicted patients normalizes regulatroy T cells but does not restore CD4+ T cell proliferation. Addict Biol. 2020 Dec 17:e 12998. doi: 10.1111/adb 12998.

 

Zöller J, Ebel JF, Khairnar V, Schmitt V, Klopfleisch R, Meiners J, Seiffert V, Hansen W, Buer J, Singer BB, Lang KS, Westendorf AM. CEACAM1 regulates CD8 T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitisJune 10, 2020. Gut Microbes 2020; 11(6): 1790-1805

 

Liedtke K, Alter C, Günther A, Hövelmeyer N, Klopfleisch R, Naumann R, Wunderlich FT, Buer J, Westendorf AM, Hansen W. Endogenous CD83 Expression in CD4+   Conventional T Cells Controls Inflammatory Immune Responses. J Immunol 2020; 204(12): 3217-3226.

 

 

2019

 

Plöhn S, Hose M, Schlüter A, Michel L, Diaz-Cano SJ, Hendgen-Cotta U, Banga JP, Bechrakis N, Hansen W, Eckstein A, Berchner-Pfannschmidt U. Fingolimod improves the outcome of experimental Graves' disease and associated orbitopathy by modulating the autoimmune response to the thyroid stimulating hormone receptor. Thyroid 2019; 29: 1286-1301.

 

Hose M, Günther A, Abberger H, Begum S, Korencak M, Becker KA, Buer J, Westendorf AM, Hansen W. T Cell-specific overexpression of acid sphingomyelinase results in elevated T Cell activation and reduced parasitemia during plasmodium yoelii Infection. Front Immunol, 2019; 10: 1225.

 

Meiners M, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker KA, Zöller J, Hose M, Kleuser B, Hermann DM, Kolesnick R, Buer J, Hansen W, Westendorf AM. Intestinal acid sphingomyelinase protects from severe pathogen driven colitis. Front Immunol. 2019; 10: 1386.

 

Pastille E, Wasmer MH, Adamczyk A, Vu VP, Mager LF, Phuong NNT, Palmieri V, Simillion C, Hansen W, Kasper S, Schuler M, Muggli B, McCoy KD, Buer J, Zlobec I, Westendorf AM, Krebs P. The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. Mucosal Immunol. 2019; 12: 990-1003.

 

Heße C, Kollenda S, Rotan O, Pastille E, Adamczyk A, Wenzek C, Hansen W, Epple M, Buer J,Westendorf AM, Knuschke T. A tumor-peptide based nanopaticle vaccine elicits efficient tumor growth control in anti-tumor immunotherapy. Mol Cancer Ther 2019; 18: 1069-80.

 

Verhasselt HL, Radke J, Schmidt D, Killengray D, Scharmann U, Rickerts V, Hansen W, Seidel D, Falces-Romero I, Buer J, Rath PM, Steinmann J. Comparison of genotyping methods for Cunninghamella bertholletiae. Mycoses. 2019; 62: 519-25. 

 

Schulte-Mecklenbeck A, Kleffner I, Beuker C, Wirth T, Hartwig M, Schmidt-Pogoda A, Klotz L, Hansen W, Wiendl H, Meuth SG, Gross CC, Minnerup J. Immunophenotyping of cerebrospinal fluid cells in ischaemic stroke. Eur J Neurol 2019; 26: 919-26.

 

Thiel J, Alter C, Luppus S, Eckstein A, Tan S, Führer D, Pastille E, Westendorf AM, Buer J, Hansen W. MicroRNA-183 and microRNA-96 are associated with autoimmune responses by regulating T cell activation. J Autoimmun. 2019 Jan;96:94-103. doi: 10.1016/j.jaut.2018.08.010. Epub 2018 Sep 7. PMID: 30201436.

 

 

2018

 

Plöhn S, Edelmann B, Japtok L, He X, Hose M, Hansen W, Schuchman EH, Eckstein A, Berchner-Pfannschmidt U. CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5391-5397. doi: 10.1167/iovs.18-25466.

 

Herz J, Köster C, Crasmöller M, Abberger H, Hansen W, Felderhoff-Müser U, Bendix I. Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal mice. Front Immunol. 2018 Aug 6;9:1696.doi: 10.3389/fimmu.2018.01696

 

Herz J, Köster C, Reinboth BS, Dzietko M, Hansen W, Sabir H, van Velthoven C, Bendix I, Felderhoff-Müser U. Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury. Brain Behav Immun 2018 May;70:118-130. doi: 10.1016/j.bbi.2018.02.006.

Knuschke T, Rotan O, Bayer W, Kollenda S, Dickow J, Sutter K, Hansen W, Dittmer U, Lang KS, Epple M, Buer J, Westendorf AM. Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection. Front Immunol. 2018 Apr 23;9:614. doi: 10.3389/fimmu.2018.00614. PMID: 29740425; PMCID: PMC5924795.br /

 

Batzke K, Büchel G, Hansen W, Schramm A. TrkB-Target Galectin-1 Impairs immune Activation and Radiation Responses in Neuroblastoma: Implications for Tumour Therapy. Int J Mol Sci 2018 Mar 2;19(3). pii: E718. doi: 10.3390/ijms19030718


2017

 

Smirnov A, Pohlmann S, Nehring M, Ali S, Mann-Nüttel R, Scheu S, Antoni AC, Hansen W, Büttner M, Gardiasch M, Westendorf AM, Wirsdörfer F, Pastille E, Dudda M, Flohé S. Sphingosine 1-phosphate-and CCR2-dependent activation of CD4+ plasmacytoid dendritic cells in the bone marrow contributes to signs of Sepsis-Induced immunosuppression. Front. Immunol. 2017 Nov 23: doi.org/10.3389/fimmu.2017.01622.

 

Ueffing K, Abberger H, Westendorf AM, Matuschewski K, Buer J, Hansen W. Conventional CD11c high dendritic cells are essential for T cell priming during the initial phase of plasmodium yoelii infection, but are dispensable at later time points. Front Immunol 5:1333. doi: 10.3389/fimmu.2017.01333.

 

Pastille E, Frede A, McSorley H, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM. Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PlosPathogens 2017; 13 (9): e1006649. doi: 10.1371/Journal.ppat.1006649.

 

Frede A, Neuhaus B, Knuschke T, Wadwa M, Kollenda S, Klopfleisch R, Hansen W, Buer J, Bruder D, Epple M, Westendorf AM. Local delivery of siRNA-loaded calcium Phosphate nanopartiles abates pulmonary Inflammation. Nanomedicine 2017; 13: 2395-2403. doi: 10.1016/j.nano.2017.08.001.

 

Adamczyk A, Gageik D, Frede A, Pastille E, Hansen W, Rueffer A, Buer J, Büning J, Langhost J, Westendorf AM. Differential expression of GPR15 on T cells during ulcerative colitis. JCI Insight. 2017; 2(8). pii: 90585. doi: 10.1172/jci.insight.90585.  

 

Westendorf AM, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Jendrossek V. Hypoxia Enhances Immunosuppression by Inhibiting CD 4+Effector T Cell Function and Promoting Treg Activity. Cell Physiol Biochem 2017; 41: 1271-1284. doi: 10.1159/000464429. 

 

Loevenich K, Ueffing K, Abel S, Hose M, Matuschewski K, Westendorf AM, Buer J, Hansen W. DC-Derived IL-10 Modulates Pro-inflammatory Cytokine production and Promotes Induction of CD4+ IL-10 10+ Regulatory T cells during Plasmodium yoelii Infection. Front Immunol. 2017; 8:152. doi 10.3389/fimmu. 2017.00152.

 

2016

Gamrad L, Rehbock C, Westendorf AM, Buer J, Barcikowski S, Hansen W. Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates. Sci Rep. 2016 Jul 6;6:28709. doi: 10.1038/srep28709. PMID: 27381215; PMCID: PMC4933883.

 

Buechel G, Schulte JH, Harrison L, Schüller U, Hansen W, Schramm A (2016). Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma. Oncoimmunology 5:e113178.

  

Knuschke T , Rotan  O, Bayer  W, Sokolova  V, Hansen  W, Sparwasser  T, Dittmer  U, Epple M, Buer  J, Westendorf  AM. 2016. Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology 13:24

 

Wadwa M, Klopfleisch R, Adamczyk A, Frede A, Pastille E, Mahnke K, Hansen W, Geffers R, Lang KS, Buer J, Büning J, Westendorf AM. IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites. Mucosal Immunol. 2016 Sep;9(5):1263-77. doi: 10.1038/mi.2015.132. Epub 2016 Jan 6. PMID: 26732675.

 

Abel S, Ueffing K, Tatura R, Hutzler M, Hose M, Matuschewski K, Kehrmann J, Westendorf AM, Buer J, Hansen W. 2016. Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cells. Immunology 148: 197-205.

 

Berchner-Pfannschmidt U, Moshkelgosha S, Diaz-Cano S, Edelmann B, Görtz GE, Horstmann M, Noble A, Hansen W, Eckstein A, Banga JP. Comparative Assessment of Female Mouse Model of Graves' Orbitopathy Under Different Environments, Accompanied by Proinflammatory Cytokine and T-Cell Responses to Thyrotropin Hormone Receptor Antigen. Endocrinology. 2016 Apr;157(4):1673-82. doi: 10.1210/en.2015-1829. Epub 2016 Feb 12. PMID: 26872090.

 

Serdar M, Herz J, Kempe K, Lumpe K, Reinboth BS, Sizonenko SV, Hou X, Herrmann R, Hadamitzky M, Heumann R, Hansen W, Sifringer M, van de Looij Y, Felderhoff-Müser U, Bendix I. Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. Brain Behav Immun. 2016 Feb;52:106-119. doi: 10.1016/j.bbi.2015.10.004. Epub 2015 Oct 21. PMID: 26456693.

 

2015

Seifert V, Zoeller J, Klopfeisch R, Wadwa M, Hansen W, Buer J, Riedel C, Westendorf AM 2015. IL10-Deficiency in CD4*T Cells Exacerbates the IFNy and IL17 Response During Baceteria Induced Colitis. Cell Physiol Biochem 36: 1259-73.

Tatura R, Zeschnigk M, Hansen W, Steinmann J, Vidigal PG, Hutzler M, Pastille E, Westendorf AM, Buer J, Kehrmann J. 2015. Relevance of Foxp3⁺ regulatory T cells for early and late phases of murine sepsis. Immunology 146: 144-56.

 

Niezold T, Storcksdieck Genannt Bonsmann M, Maaske A, Temchura V, Heinecke V, Hannaman D, Buer J, Ehrhardt C, Hansen W, Überla K, Tenbusch M. 2015. DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance? Immunology 145: 519-33.

 

Wirsdörfer F, Bangen JM, Pastille E, Hansen W, Flohé SB. 2015. Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice. Clin Sci 128: 825-38.

 

2014

Jost NH, Abel S, Hutzler M, Sparwasser T, Zimmermann A, Roers A, Müller W, Kopfleisch R, Hengel H, Westendorf AM, Buer J and Hansen W. 2014. Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunology and Cell Biology. 92:860-71.

 

Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J and Westendorf AM . 2014. Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protecitve immunity during acute and chronic retroviral infection. Nanomedicine. 10:1787-98

 

Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD , Schuler M, Sackaguchi S, Roers A , Muller W, Hansen W, Buer J and Westendorf AM. 2014. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res. 74:4258-69

 

2013

Herz J, Hagen SI, Bergmüller E, Sabellek P, Göthert JR, Buer J, Hansen W, Hermann DM and Doeppner T. 2013. Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses. Neurobiol. Dis. 62C: 456-68.

 

Knuschke T, Sokolova V, Rotan O, Wadwa M, Tenbusch M, Hansen W, Staeheli P, Epple M, Buer J and Westendorf AM. 2013. Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection. J. Immunol. 190:6221-9.

 

Hansen W. 2013. Neuropilin-1 guides regulatory T cells into VEGF-producing melanoma. Oncolmmunology. 2: e23039.

 

2012

Jeron A, Hansen W, Buer J, Geffers R and Bruder D. 2012. ChIP-on-Chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells. BMC Genomics 13: 705.

 

Hansen, W., M. Hutzler, S. Abel, C. Alter, C. Stockmann, S. Kliche, J. Albert, T. Sparwasser, S. Sakaguchi, A.M. Westendorf, D. Schadendorf, J. Buer and I. Helfrich. 2012. Neuropilin-1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J. Exp. Med. 209: 2001-16.

 

Riß, G.-L., D.-I. Chang, O. Zafiris, A.M. Westendorf, J. Buer, N. Scherbaum, and W. Hansen. 2012. Opioid maintenance therapy restores CD4+ T cell function by normalizing CD4+CD25high regulatory T cell frequencies in heroin user. Brain Behav Immun 26: 972-8.

 

Abel, S., N. Lückheide, A.M. Westendorf, R. Geffers, A. Roers, W. Mueller, T. Sparwasser, K. Matuschewski, J. Buer and W. Hansen. 2012. Strong impact of CD4+Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J. Immunol. 188: 5467-77.

 

2011

Fleissner D, Loser K, Hansen W, Dissemond J, Körber A, Beissert S, Buer J and Westendorf AM. 2011. In vitro induced CD8+ regulatory T cells inhibit skin inflammation. Eur J Microbiol Immunol 1: 208–214.

 

Fleissner D, Frede A, Knott M, Knuschke T, Geffers R, Hansen W, Dobos G, Langhorst,&nbsp J, Buer J, Westendorf AM. 2011. Generation and function of immunosuppressive human and murine CD8+ T cells by TGF-β and retinoid acid. Immunology 134: 82-92.

 

2010

Fleissner D, Hansen W, Geffers R, Buer J and Westendorf AM. 2010. Local induction of immunosuppressive CD8+ T cells in the gut associated lymphoid tissues. PLOS One 5: e15373.

 

Hansen W, Westendorf AM, Toepfer T, Mauel T, Gruber AD, Geffers R and Buer J. 2010. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. Genes Immun. 11: 357-361.      

 

Bendix I, Pfueller CF, Leuenberger T, Glezeva N, Siffrin, Muller Y, Prozorovski T, Hansen W, Schulze-Topphoff U, Loddenkemper C, Zipp F and Waiczies S. 2010. MAPK3 deficiency drives autoimmunity via dendritic cell arming. Eur. J. Immunol. 40: 1486-1495.

 

Westendorf AM, Fleissner D, Hansen W and Buer J. 2010. T cells, dendritic cells and epithelial cells in intestinal homeostasis. Int. J. Med. Microbiol. 300: 11-18.

 

2009

Westendorf AM, Fleissner D, Groebe L, Jung S, Gruber AD, Hansen W and Buer J. 2009. CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven CD4+Foxp3+ interaction with intestinal epithelial cells independent of local dendritic cells. Gut 58: 211-219.

 

2008

Hansen W, Westendorf AM and Buer J. 2008. Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation. Inflamm Allergy Drug Targets 7: 217-223.

 

Reinwald S, Wiethe C, Westendorf AM, Breloer M., Probst-Kepper M, Fleischer,&nbsp B; Steinkasserer A, Buer J and Hansen W. 2008. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. J. Immunol. 180: 5890-5897.

 

2007

Ukena, S.N., A. Singh, U. Dringenberg, R. Engelhardt, U. Seidler, W. Hansen, A. Bleich, D. Bruder, A. Franzke, G. Rogler, S. Suerbaum, J. Buer, F. Gunzer and A.M. Westendorf. 2007. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS ONE 12, e1308

 

Hansen, W., A.M. Westendorf, S. Reinwald, D. Bruder, S. Deppenmeier, L. Groebe, M.  Probst-Kepper, A.D. Gruber, R. Geffers and J. Buer. 2007. Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3lowCD25- regulatory T cells. J. Immunol. 179: 8059-8068.

 

 2006

Westendorf, A.M., D. Bruder, W. Hansen and J. Buer. 2006. Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in transgenic autoimmune mouse model. Ann. N.Y. Acad. Sci. 1072: 401-406.

 

Pfoertner, S., A. Jeron, M. Propst-Kepper, C.A. Guzman, W. Hansen, A.M. Westendorf, T.  Toepfer, A.J. Schrader, A. Franzke, J. Buer and R. Geffers. 2006. Signatures of Human Regulatory T Cells: An Encounter with Old Friends and New Players. Genome Biology 7: R54.1-54.18.

 

Westendorf AM, Fleisser D, Deppenmeier S, Gruber AD, Bruder D, Hansen W, Liblau R and Buer J. 2006. Autoimmune mediated intestinal inflammation – impact and regulation of antigen specific CD8+ T cells. Gastroenterology 131: 510-524.

 

Hansen W, Loser K, Westendorf AM, Bruder D, Pfoertner S, Siewert C, Huehn J, Beissert S, Buer J. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. J Immunol. 2006 Jul 1;177(1):209-15. doi: 10.4049/jimmunol.177.1.209. PMID: 16785516.

 

de Buhr MF, Mähler M, Geffers R, Hansen W, Westendorf AM, Lauber J, Buer J, Schlegelberger B, Hedrich HJ, Bleich A. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006 May 16;25(3):426-34. doi: 10.1152/physiolgenomics.00022.2005. PMID: 16705022.

 

Veldman C, Pahl A, Beissert S, Hansen W, Buer J, Dieckmann D, Schuler G, Hertl M. Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cells. J Immunol. 2006 Mar 1;176(5):3215-22. doi: 10.4049/jimmunol.176.5.3215. Erratum in: J Immunol. 2012 Oct 1;189(7):3779. PMID: 16493082.

 

 

2005

Ukena SN, Westendorf AM, Hansen W, Rohde M, Geffers R, Coldewey S, Suerbaum S, Buer J, Gunzer F. The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1. BMC Med Genet. 2005 Dec 13;6:43. doi: 10.1186/1471-2350-6-43. PMID: 16351713; PMCID: PMC1326229.

 

Buer J, Westendorf AM, Zeng AP, He F, Hansen W and Probst-Kepper M. 2005. Mechanisms of central and peripheral T cell tolerance: An update. Transfusion Medicine and Hemotherapy 32: 384-399.

 

Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J. On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes. 2005 Dec;54(12):3395-401. doi: 10.2337/diabetes.54.12.3395. PMID: 16306354.

 

Pfoertner S, Goelden U, Hansen W, Toepfer T, Geffers R, Ukena SN, von Knobloch R, Hofmann R, Buer J, Schrader AJ. Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma. Tumour Biol. 2005 Nov-Dec;26(6):313-23. doi: 10.1159/000089262. Epub 2005 Oct 25. PMID: 16254461.

 

Goelden U, Pfoertner S, Hansen W, Toepfer T, von Knobloch R, Hofmann R, Buer J, Schrader AJ. Expression and functional influence of cellular retinoic acid-binding protein II in renal cell carcinoma. Urol Int. 2005;75(3):269-76. doi: 10.1159/000087807. PMID: 16215318.

 

Loser K, Hansen W, Apelt J, Balkow,&nbsp S; Buer J and Beissert S. 2005. In vitro generated regulatory T cells induced by Foxp3-retrovirus infection control murine contact hypersensitivity and systemic autoimmunity. Gene Therapy 12: 1294-1304.

 

Hansen W, Grabenhorst E, Nimtz M, Müller K, Conradt HS and Wirth M. (2005). Generation of serum-stabilized retroviruses: Reduction of a1,3-gal-epitope synthesis in a murine NIH3T3-derived packaging cell line by expression of chimeric glycosyltransferases. Metab. Eng.7: 221-228.

 

Westendorf AM, Templin M, Geffers R, Deppenmeier S, Gruber AD, Probst-Kepper M, Hansen W, Liblau RS, Gunzer F, Bruder D and Buer J. 2005. CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune regulation. Gut 54: 60-69.

 

2004

Hansen W and Buer J. 2004. Role of regulatory T cells for the outcome of the allo- and autoimmune response. Transfusion Medicine and Hemotherapy 31: 322-331.

 

Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W. Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol. 2004 Mar;34(3):623-630. doi: 10.1002/eji.200324799. Erratum in: Eur J Immunol. 2004 May;34(5):1498. PMID: 14991591..

 

2003

Franzke A, Piao W, Lauber J, Gatzlaff P, Könecke C, Hansen W, Schmitt-Thomsen A, Hertenstein B, Buer J, Ganser A. G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases. Blood. 2003 Jul 15;102(2):734-9. doi: 10.1182/blood-2002-04-1200. Epub 2003 Apr 3. PMID: 12676791.

 

Matussek A, Lauber J, Bergau A, Hansen W, Rohde M, Dittmar KE, Gunzer M, Mengel M, Gatzlaff P, Hartmann M, Buer J, Gunzer F. Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cells. Blood. 2003 Aug 15;102(4):1323-32. doi: 10.1182/blood-2002-10-3301. Epub 2003 Apr 17. PMID: 12702508.