Personal homepage PD Dr. rer. nat. Bernd Giebel


Personal data:

Name: PD Dr. rer. nat. Bernd Giebel (Workgroup leader)
Workgroup: WG Giebel
Telephone: +49 (0) 201-723-4204
Fax: +49 (0) 201-723-5906
Email: bernd.giebel@uk-essen.de
Room: 2.27

 

 

 

 

 

Publications


2015 Impact Faktor
1. Denecke B, Horsch LD, Radtke S, Fischer JC, Horn PA, Giebel B. Human endothelial colony-forming cells expanded with an improved protocol are a useful endothelial cell source for scaffold-based tissue engineering.J Tissue Eng Regen Med. 2015; 9 (11): E84-97 5.2
   
2. Murke F, Castro SVC, Giebel B, Görgens A. Concise Review: Asymmetric Cell Divisions in Stem Cell Biology. Symmetry. 2015; 7: 2025-2037 0.8
   
3. Loeffek S, Ullrich N, Görgens A, Murke F, Eilebrecht M, Menne C, Giebel B, Schadendorf D, Singer BB, Helfrich I. CEACAM1-4L promotes anchorage-independent growth in melanoma. Front Oncol. 2015; 5: 234  
   
4. Börger V, Görgens A, Rohde E, Giebel B. Therapeutisches Potenzial von extrazellulären Vesikeln aus mesenchymalen Stamm- bzw. Stromazellen. Transfusionsmedizin. 2015; 5: 131–137  
   
5. Doeppner TR, Herz J, Gorgens A, Schlechter J, Ludwig AK, Radtke S, de Miroschedji K, Horn PA, Giebel B and Hermann DM. Extracellular vesicles improve post-stroke neuroregeneration and prevent post-ischemic immunosuppression. Stem Cells Transl Med. 2015; 4 (10): 1131-43 5.7
   
6. Görgens A, Giebel B. Wie unser Blut entsteht – neue Erkenntnisse zur Hämatopoese. BIOspektrum. 2015; 21 (3): 290-293  
   
7. Yáñez-Mó M, Siljander PRM, Andreu Z, [...], Giebel B, [...], Vasconcelos MH, Wauben MHM, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4: 27066  
   
8. Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M. Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3. Stem Cells Dev. 2015 May 11 [Epub] 4.2
   
9. Radtke S, Görgens A, Kordelas L, Schmidt M, Kimmig KR, Köninger A, Horn PA, Giebel B. CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants. Br. J. Haematol. 2015; 169 (6):868-78 5.0
   
10. Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody PLoS ONE. 2015; 10(1): e0116800 3.5
2014  
1. Radtke, S., Giebel, B., Wagner, W., and Horn, P.A. Platelet lysates and their role in cell therapy. ISBT Science Series. 2014; 9(1): 193-7  
   
2. Brandau S, Jakob M, Bruderek K, Bootz F, Giebel B, Radtke S, Mauel K, Jäger M, Flohé SB, Lang S. Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes. PLoS One. 2014; 9(11): e114201 3.5
   
3. Müller CR, Mytilineos J, Ottinger H, Arnold R, Bader P, Beelen D, Bornhäuser M, Dreger P, Eiermann T, Einsele H, Faé I, Fischer G, Füssel M, Holler E, Holzberger G, Horn PA, Kröger N, Lindemann M, Seidl C, Spriewald B, Süsal C, Blasczyk R, Finke J. Deutscher Konsensus 2013 zur immungenetischen Spenderauswahl für die allogene Stammzelltransplantation. Transfusionsmedizin. 2014; 4: 190-6  
   
4. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, [...], Giebel B, [...], Zeidler R, Gho YS. EVpedia: A Community Web Portal for Extracellular Vesicles Research. Bioinformatics. 2014; 31 (6): 933-9 4.6
   
5. Görgens A, Ludwig AK, Möllmann M, Krawczyk A, Dürig J, Hanenberg H, Horn PA, Giebel B. Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the Lympho-Myeloid and Erythro-Myeloid Lineages. Stem Cell Reports. 2014; 3(6): 1058-72 5.4
   
6. Malyar NM, Radtke S, Malyar K, Arjumand J, Horn PA, Kröger K, Freisinger E, Reinecke H, Giebel B, Brock FE. Autologous Bone Marrow Mononuclear Cell Therapy Improves Symptoms in Patients with End-Stage Peripheral Arterial Disease and Reduces Inflammation Associated Parameters. Cytotherapy. 2014; 16(9): 1270-9 3.3
   
7. Kordelas L, Rebmann V, Ludwig AK, Radtke S, Ruesing J, Doeppner TR, Epple M, Horn PA, Beelen DW, Giebel B. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia. 2014; 28(4): 970-3 10.2
   
8. Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014; 16(2): 170-80 3.3
2013  
1. Görgens A, Radtke S, Horn PA, Giebel B. New Relationships of Human Hematopoietic Lineages Facilitate Detection of Multipotent Hematopoietic Stem and Progenitor Cells. Cell Cycle. 2013; 12(22): 3478-82 5.2
   
2. Muturi HT, Dreesen, JD, Nilweski E, Jastrow H, Giebel B, Ergun S, Singer BB. Tumor and Endothelial Cell-Derived Microvesicles Carry Distinct CEACAMs and Influence T-Cell Behavior. PLOS One. 2013; 8(9): e74654 3.7
   
3. Görgens A, Radtke S, Moellmann M, Cross M, Duerig J, Horn PA, Giebel B. Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages. Cell Reports. 2013; 3(5): 1539-52 8.4
   
4. Krawczyk A, Arndt MAE, Grosse-Hovestc L, Weichert W, Giebel B, Dittmer U, Hengel H, Jäger D, Schneweis KE, Eis-Hübingerg AM, Roggendorf M, Krauss J. Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody. Proc Natl Acad Sci USA. 2013; 110(17): 6760-5 9.7
   
5. Schilling B, Sucker A, Griewank K, Zhao F, Weide B, Görgens A, Giebel B, Schadendorf D, Paschen A. Vemurafenib reverses immunosuppression by myeloid derived suppressor cells. Int J Cancer. 2013; 133(7): 1653-63 5.4
2012  
1. Gortner L, Felderhoff-Müser U, Monz D, Bieback K, Klüter H, Jellema R, Kramer BW, Keller M, Reiss I, Horn PA, Giebel B. Regenerative Therapies in Neonatology: Clinical Perspectives. Klin Padiatr. 2012; 224(4): 233-240 1.6
   
2. Goergens A, Beckmann J, Ludwig AK, Möllmann M, Dürig J, Horn PA, Rajendrand L, Giebel B. Lipid raft redistribution and morphological cell polarization are separable processes providing a basis for hematopoietic stem and progenitor cell migration. Int J Biochem Cell Biol. 2012; 1121-32 5.0
   
3. Doeppner TR, Ewert T AS, Tönges L, Herz J, Zechariah A, El-Ali A, Ludwig AK, Giebel B, Nagel F, Dietz PH, Weise J, Hermann DM, Bähr M. Transduction of Neural Precursor Cells with TAT-Hsp70 Chaperone: Therapeutic Potential Against Ischemic Stroke After Intrastriatal and Systemic Transplantation. Stem Cells. 2012; 30(6): 1297-310 7.8
   
4. Heyder J, Heinold A, Fiedler G, Opelz G, Tran TH. Characterization of four new HLA alleles: HLA-B*15:01:18, HLA-B*44:110, HLA-C*04:01:22 and HLA-DQB 1*05:14. Tissue Antigens. 2012; 79(3): 209-10 3.0
   
5. Giebel B, Wodarz A. Notch Signaling: Numb Makes the Difference. Current Biology. 2012; 22(4): 133-35 10.3
   
6. Ludwig AK, Giebel B. EXOSOMES: Small vesicles participating in intercellular communication. Int J Biochem Cell Biol. 2012; 44(1): 11-15 4.9
2011  
1. Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces. 2011; 87(1): 146-50 2.6
   
2010  
1. Hemeda H, Jakob M, Ludwig AK, Giebel B, Lang S, Brandau S. Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev. 2010; 19(5): 693-706 4.1
   
2. Radtke S, Görgens A, Punzel M, Horn PA, Giebel B.Establishment of an extended in vitro assay to detect the most primitive human hematopoietic cells at a clonal level. J Stem Cells Regen Med. 2010; 6(2): 48  
   
3. Goergens, A; Beckmann, J; Rajendran, L; Horn, PA; Giebel, B. Functional analyses of cell polarity organization in human hematopoietic stem and progenitor cells. 2010; 6(2): 74  
   
Books  
Görgens A, Giebel B. (2010): Self-Renewal of Primitive Hematopoietic Cells: A Focus on Asymmetric Cell Division, Kapitel 3 in “Umbilical Cord Blood: A Future for Regenerative Medicine?” Editors: Suzanne Kadereit, Gerald Udolph. World Scientific Publishing, 51-75.  
   
2009  
1. Rajendran L, Beckmann J, Magenau A, Boneberg EM, Gaus K, Viola A, Giebel B, Illges H. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLoS ONE. 2009; 4(12): e8290 2.1
   
2008  
1. Giebel B, Bruns I. Self-renewal versus differentiation in hematopoietic stem and progenitor cells: a focus on asymmetric cell divisions. Curr Stem Cell Res Ther. 2008; 3(1): 9-16 3.6
   
2. Giebel B. Cell polarity and asymmetric cell division within human hematopoietic stem and progenitor cells. Cells Tissues Organs. 2008; 188(1-2): 116-26 2.4
   
3. Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart LA, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A, Giebel B, Wischhusen J, Reifenberger G, Hau P, Beier CP. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 2008; 68(14): 5706-15 7.5
   
4. Giebel B, Punzel M. Lineage development of hematopoietic stem and progenitor cells. Biol Chem. 2008; 389(7): 813-24 3.0

1999

Giebel B. (1999)
The notch signaling pathway is required to specify muscle progenitor cells in Drosophila.
Mech Dev 86(1-2): 137-45
 


[Summary]

1997

Giebel B, Campos-Ortega JA. (1997)
Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.
Proc Natl Acad Sci U S A 94(12): 6250-4
 


[Summary]

Giebel B, Stüttem I, Hinz U, Campos-Ortega JA. (1997)
Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila.
Mech Dev 63(1): 75-87
 


[Summary]

1994

Hinz U, Giebel B, Campos-Ortega JA. (1994)
The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes.
Cell 76(1): 77-87
 


[Summary]