Selection of High Impact Publications:

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ*, Brandau S*. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. (2017) Nat Commun. 8:14600. *co-senior authors


Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S*, Schuler M*, Lang PA*, Lang KS*. (2017) Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression. Nat Commun. 8:14447. * co-senior authors


Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M. (2015) Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods. 12(5):445-52


Davey MS, Tamassia N, Rossato M, Bazzoni F, Calzetti F, Bruderek K, Sironi M, Zimmer L, Bottazzi B, Mantovani A, Brandau S, Moser B, Eberl M, Cassatella MA. (2011) Failure to detect production of IL-10 by activated human neutrophils. Nat Immunol. (correspondence) 12(11):1017-8.


Brandau S, Hartl D. (2017) Lost in neutrophil heterogeneity? CD10! Blood. 129(10):1240-1241.


Brandau S, Böhle A. (2001) Activation of NK Cells by Bacillus Calmette-Guérin (BCG). Eur Urol 39, 508-514


Suttmann H, Riemensberger J, Bentien G, Schmaltz D, Stöckle M, Jocham D, Böhle A, Brandau S. (2006) Neutrophil granulocytes are required for effective BCG-immunotherapy of bladder cancer and orchestrate local immune responses. Cancer Res 66 (16), 8250-8257



Selection of Reviews:

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI. (2016) Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 7:12150.


Dumitru, C.A., Moses, K., Trellakis, S., Lang, S., Brandau, S. Neutrophils and granulocytic myeloid-derived suppressor cells: Immunophenotyping, cell biology and clinical relevance in human oncology (2012) Cancer Immunology, Immunotherapy, 61 (8), pp. 1155-1167.


Moses K, Brandau S. (2016) Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells. Semin Immunol. 28 (2), 187-96.


Dumitru, C.A., Lang, S., Brandau, S. Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression (2013) Seminars in Cancer Biology, 23 (3), pp. 141-148.


Brandau, S., Moses, K., Lang, S. The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins? (2013) Seminars in Cancer Biology, 23 (3), pp. 171-182.



Selection of highly cited Articles:

Brandau, S., Trellakis, S., Bruderek, K., Schmaltz, D., Steller, G., Elian, M., Suttmann, H., Schenck, M., Welling, J., Zabel, P., Lang, S.

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties (2011) Journal of Leukocyte Biology, 89 (2), pp. 311-317.


Trellakis, S., Bruderek, K., Dumitru, C.A., Gholaman, H., Gu, X., Bankfalvi, A., Scherag, A., Hütte, J., Dominas, N., Lehnerdt, G.F., Hoffmann, T.K., Lang, S., Brandau, S. Polymorphonuclear granulocytes in human head and neck cancer: Enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease (2011) International Journal of Cancer, 129 (9), pp. 2183-2193.


Hemeda, H., Jakob, M., Ludwig, A.-K., Giebel, B., Lang, S., Brandau, S. Interferon-γ and tumor necrosis factor-α differentially affect cytokine expression and migration properties of mesenchymal stem cells (2010) Stem Cells and Development, 19 (5), pp. 693-706.


Dumitru, C.A., Gholaman, H., Trellakis, S., Bruderek, K., Dominas, N., Gu, X., Bankfalvi, A., Whiteside, T.L., Lang, S., Brandau, S.

Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation

(2011) International Journal of Cancer, 129 (4), pp. 859-869.


Esendagli, G., Bruderek, K., Goldmann, T., Busche, A., Branscheid, D., Vollmer, E., Brandau, S. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer (2008) Lung Cancer, 59 (1), pp. 32-40.


Brandau, S., Jakob, M., Hemeda, H., Bruderek, K., Janeschik, S., Bootz, F., Lang, S. Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge (2010) Journal of Leukocyte Biology, 88 (5), pp. 1005-1015.


Trellakis, S., Bruderek, K., Hütte, J., Elian, M., Hoffmann, T.K., Lang, S., Brandau, S. Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer (2013) Innate Immunity, 19 (3), pp. 328-336.


Böhle, A., Brandau, S. Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer (2003) Journal of Urology, 170 (3), pp. 964-969.


Brandau, S., Riemensberger, J., Jacobsen, M., Kemp, D., Zhao, W., Zhao, X., Jocham, D., Ratliff, T.L., Bhle, A. NK cells are essential for effective BCG immunotherapy (2001) International Journal of Cancer, 92 (5), pp. 697-702.


Suttmann, H., Riemensberger, J., Bentien, G., Schmaltz, D., Stöckle, M., Jocham, D., Böhle, A., Brandau, S. Neutrophil granulocytes are required for effective Bacillus Calmette-Guérin immunotherapy of bladder cancer and orchestrate local immune responses (2006) Cancer Research, 66 (16), pp. 8250-8257.


Mandruzzato, S., Brandau, S., Britten, C.M., Bronte, V., Damuzzo, V., Gouttefangeas, C., Maurer, D., Ottensmeier, C., van der Burg, S.H., Welters, M.J.P., Walter, S. Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study (2016) Cancer Immunology, Immunotherapy, 65 (2), pp. 161-169.