Projekte Jablonska

Dr. rer. nat. Jadwiga Jablonska

Research group leader

Tel: 0201 723 3190

jadwiga.jablonska@uk-essen.de

Translational Oncology

Neutrophils are the most abundant population of white blood cells in the circulation that play a key role in the innate immune system responses. In the past, these cells were viewed as merely dedicated to phagocytosis and the production of reactive oxygen species (ROS). Nowadays, they are recognized for their extreme versatility with regard to function and as important players influencing tumor development. Neutrophils are major effectors of acute inflammation, but also contribute to chronic inflammatory conditions and adaptive immune responses.

Inflammation has been associated with increased susceptibility for cancer. Neutrophils, as a crucial component of this process, play essential role in inflammation-driven tumorigenesis therefore representing an independent prognostic marker in a broad variety of neoplasias. Depending on the cytokine milieu in the tumor microenvironment, tumor infiltrating neutrophils (TANs) appear to have diverse phenotypes i.e. tumor promoting (N2) or inhibiting (N1). Importantly, alterations in neutrophil differentiation could be responsible for the changes in the host predisposition for tumor development, since these cells have a capacity to influence tumor angiogenesis, growth and metastasis.

Figure 1. Properties of N1 and N2 neutrophils in the context of tumors. Neutrophil function in cancer is dictated by environmental cues. TGF-β is a potent driver of the transition from N1 to N2 phenotype whereas IFN-β is a potent driver of the transition in the opposite direction (modified from Granot & Jablonska, 2015).

Our research group focuses on the neutrophil-dependent immunoregulatory mechanisms that are responsible for the cancerogenesis in mice and human. We study the molecular mechanisms involved in neutrophil polarization, mobilization and activation. Our ultimate aim is to identify effective therapeutic approaches to target tumor- promoting neutrophil functions.

Moreover, we are interested in overall neutrophil biology, i.e. development, differentiation, activation, migration and responses to various inflammatory stimuli in disease. We analyze the role of multiple cytokines and growth factors in the regulation of emergency myelopoiesis, factors involved in neutrophil homing and the correlation between neutrophil activation and the outcome of disease.

Georg Korschunow

MD student

Team

Ilona Spyra (M.Sc)

Technische Assistentin

“AG Jablonska”

ilona.spyra@uk-essen.de

Sharareh Bordbari (M.Sc)

Doktorandin

wissenschaftliche Mitarbeiterin

“AG Jablonska”

sharareh.bordbari@uk-essen.de

Ekatarina Pylaeva (MD)

Doktorandin

wissenschaftliche Mitarbeiteirn

“AG Jablonska”

ekaterina.pylaeva@uk-essen.de

Sandra Wasielewski

Study Nurse

sandra.wasielewski@uk-essen.de

Georg Koschunow

MD Student

Dr. med. Nina Dominas

Oberärztin

Clinical research fellow

nina.dominas@uk-essen.de

 

Dr. med. Freya Dröge

Assistenzärztin

Clinical research fellow

freya.droege@uk-essen.de

 

Dr. med. Benedikt Höing

Assistenzarzt

Clinical research fellow

benedikt.hoeing@uk-essen.de

Dr. med. Timon Hussain

Assistenzarzt

Clinical research fellow

timon.hussain@uk-essen.de

 

Oliver Kanaan

Assistenzarzt

Clinical research fellow

oliver.kanaan@uk-essen.de

 

Kruthika Thangavelu

Assistenzärztin

Clinical research fellow

kruthika.thangavelu@uk-essen.de

Dr. med. Sonja Ludwig

Assistenzärztin

Clinical research fellow

sonja.funk@uk-essen.de

 

Projects