[Translate to Englisch:] Tumor suppressors: control of signaling by endocytosis.

[Translate to Englisch:] Giebel B, Wodarz A.
Curr Biol 16(3): R91-2, 2006
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.