Publications 2021


Impact Factor

1. Hermann DM, Doeppner TR, Giebel B. Circulating MicroRNAs: Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke Prediction. Stroke. 2021 Mar;52(3):954-956. 7.2
2. Rankin-Turner S, Vader P, O'Driscoll L, Giebel B, Heaney LM, Davies OG. A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos. Adv Drug Deliv Rev. 2021 Jun;173:479-491. 13.3
3. Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguió-Tortajada M, Muraca M, Ochiya T, Ortiz LA, Toh WS, Yi YW, Witwer KW, Giebel B, Lim SK. Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Cytotherapy. 2021 May;23(5):373-380. 5.4
4. Abel F, Giebel B, Frey UH. Agony of choice: How anesthetics affect the composition and function of extracellular vesicles. Adv Drug Deliv Rev. 2021 Aug;175:113813. 13.3
5. Gregorius J, Wang C, Stambouli O, Hussner T, Qi Y, Tertel T, Börger V, Mohamud Yusuf A, Hagemann N, Yin D, Dittrich R, Mouloud Y, Mairinger FD, Magraoui FE, Popa-Wagner A, Kleinschnitz C, Doeppner TR, Gunzer M, Meyer HE, Giebel B, Hermann DM. Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol. 2021 Jun 8;116(1):40. 12.0
6. Budeus B, Kibler A, Brauser M, Homp E, Bronischewski K, Ross JA, Görgens A, Weniger MA, Dunst J, Kreslavsky T, Vitoriano da Conceição Castro S, Murke F, Oakes CC, Rusch P, Andrikos D, Kern P, Köninger A, Lindemann M, Johansson P, Hansen W, Lundell AC, Rudin A, Dürig J, Giebel B, Hoffmann D, Küppers R, Seifert M. Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics. J Immunol. 2021 Jun 11;ji2100113. 5.4
7. Ianni A, Hofmann M, Kumari P, Tarighi S, Al-Tamari HM, Görgens A, Giebel B, Nolte H, Krüger M, Salwig I, Pullamsetti SS, Günther A, Schneider A, Braun T. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021 May 26;9:639162. 5.2
8. Hermann DM, Doeppner TR, Giebel B. New Light on the Horizon: Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke. Stroke. 2021 Aug 4;STROKEAHA121036150. 7.2
9. Staubach S, Nardi Bauer F, Tertel T, Börger V, Stambouli O, Salzig D, Giebel B. Scaled preparation of extracellular vesicles from conditioned media. Adv Drug Deliv Rev. 2021 Aug 19;113940. PDF 13.3

Publications 2020


Impact Factor

1. Kordelas L, Görgens A, Radtke S, Horn PA, Beelen DW, Giebel B. Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows. Bone Marrow Transplant 55, 100–109 (2020). 4.6
2. Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020. 219 (3): e201907136. 8.8
3. Dampmann M, Görgens A, Möllmann M, Murke F, Dührsen U, Giebel B, Dürig J. CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo. PLoS One. 2020 Feb 10;15(2):e0228674. doi: 10.1371/journal.pone.0228674. eCollection 2020. 2.7
4. André Görgens, Bernd Giebel. Extracellular Vesicles, Essential Current Concepts in Stem Cell Biology. 219-229.  
5. Kontopoulou E, Strachan S, Reinhardt K, Kunz F, Walter C, Walkenfort B, Jastrow H, Hasenberg M, Giebel B, von Neuhoff N, Reinhardt D, Kumar Thakur B. Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics Annals of Hematology. 1–17. 2.8
6. Welsh JA, Van Der Pol E, Ger J.A. Arkesteijn, Bremer M, Brisson A, Coumans F, Dignat-George F, Duggan E, Ghiran I, Giebel B, Görgens A, Hendrix A, Lacroix R, Lannigan J, Sten F.W.M. Libregts, Lozano-Andrés E, Morales-Kastresana A, Robert S, De Rond L, Tertel T, Tigges J, De Wever O, Yan X, Nieuwland R, Marca H.M. Wauben, Nolan JP, Jones JC. MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments Journal of Extracellular Vesicles Volume 9, 2020 - Issue 1. 11.0
7. Chen Wang, Verena Börger, Maryam Sardari, Florian Murke, Jelena Skuljec, Refik Pul, Nina Hagemann, Egor Dzyubenko, Robin Dittrich, Jonas Gregorius, Mike Hasenberg, Christoph Kleinschnitz, Aurel Popa-Wagner, Thorsten R. Doeppner, Matthias Gunzer, Bernd Giebel, Dirk M. Hermann. Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils Stroke. 2020 Apr 2 6.0
8. Viktoriya Sokolova, Goodwell Nzou, Selina B. van der Meer, Tatjana Ruks, Marc Heggen, Kateryna Loza, Nina Hagemann, Florian Murke, Bernd Giebel, Dirk M. Hermann, Anthony J. Atala, Matthias Epple. Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model Acta Biomater. 2020 May 12;S1742-7061(20)30220-8 6.6
9. Verena Borger, Daniel J. Weiss, Johnathon D. Anderson, Francesc E. Borras, Benedetta Bussolati, David R.F. Carter, Massimo Dominici, Juan M. Falcon-Perez , Mario Gimona, Andrew F. Hill, Andrew M. Hoffman, Dominique de Kleijn, Bruce L. Levine, Rebecca Lim, Jan Lotvall , S. Alex Mitsialis, Marta Monguio-Tortajada, Maurizio Muraca, Rienk Nieuwland, Anna Nowocin, Lorraine O’Driscoll, Luis A. Ortiz, Donald G Phinney, Ilona Reischl, Eva Rohde, Ralf Sanzenbacher, Clotilde Thery, Wei Seong Toh, Kenneth W. Witwer, Sai Kiang Lim, Bernd Giebel. ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19, Cytotherapy (2020). 4.3
10. Tobias Tertel, Michel Bremer, Cecile Maire, Katrin Lamszus, Sven Peine, Rim Jawad, Samir E.L. Andaloussi, Bernd Giebel, Franz L. Ricklefs, André Görgens. High‐Resolution Imaging Flow Cytometry Reveals Impact of Incubation Temperature on Labeling of Extracellular Vesicles with Antibodies Cytometry Part A. 2020 3.4
11. Sai Kiang Lim, Bernd Giebel, Daniel J. Weiss, Kenneth W. Witwer, and Eva Rohde. Re: “Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19” by Sengupta et al. Stem Cells and Development 2020, ahead of print 3.1
12. Verena Börger, Simon Staubach, Robin Dittrich, Oumaima Stambouli, Bernd Giebel. “Scaled Isolation of Mesenchymal Stem/Stromal Cell‐Derived Extracellular Vesicles. Current Protocols in Stem Cell Biology, Dec. 2020, Volume 55, Issue 1 1.0
13. Hack T, Bertram S, Blair H, Börger V, Büsche G, Denson L, Fruth E, Giebel B, Heidenreich O, Klein-Hitpass L, Kollipara L, Sendker S, Sickmann A, Walter C, von Neuhoff N, Hanenberg H, Reinhardt D, Schneider M, Rasche M. “Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model. Mol Cancer Res. 2020 Oct;18(10):1603-1612. 5.9
14. Chen Y, Hoffmeister LM, Zaun Y, Arnold L, Schmid KW, Giebel B, Klein-Hitpass L, Hanenberg H, Squire A, Reinhardt HC, Dührsen U, Bertram S, Hanoun M. “Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome. Blood Adv. 2020 Oct 27;4(20):5257-5268. 4.9
15. Weiss DJ, Lim SK, Rohde E, Witwer KW, Giebel B. “Weiss Response to Sengupta et al. (DOI: 10.1089/scd.2020.0095). Stem Cells Dev. 2020 Dec;29(24):1533-1534. 3.3
16. Kaminski N, Köster C, Mouloud Y, Börger V, Felderhoff-Müser U, Bendix I, Giebel B, Herz J. “Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury. Front Cell Neurosci. 2020 Dec 10;14:601176. 4.6
17. Silini AR, Di Pietro R, Lang-Olip I, Alviano F, Banerjee A, Basile M, Borutinskaite V, Eissner G, Gellhaus A, Giebel B, Huang YC, Janev A, Kreft ME, Kupper N, Abadía-Molina AC, Olivares EG, Pandolfi A, Papait A, Pozzobon M, Ruiz-Ruiz C, Soritau O, Susman S, Szukiewicz D, Weidinger A, Wolbank S, Huppertz B, Parolini O. “Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature. Front Bioeng Biotechnol. 2020 Dec 17;8:610544. 5.5
18. Tertel T, Görgens A, Giebel B. “Analysis of individual extracellular vesicles by imaging flow cytometry. Methods Enzymol. 2020;645:55-78. 1.4

Publications 2019

2019 Impact Factor
1. Gussenhoven R, Klein L, Ophelders D, Habets D, Giebel B, Kramer BW, Schurgers LJ, Reutelingsperger C, Wolfs T Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. J. Clin. Med. 2019, 8(2), 137; doi: 10.3390/jcm8020137 PMID: 30682787 5.6
2. van Balkom BW, Gremmels H, Giebel B, Lim SK. Proteomic signature of mesenchymal stromal cell-derived small extracellular vesicles. Proteomics. 2018 Nov 23:e1800163. doi: 10.1002/pmic.201800163. PMID: 30467989 3.1
3. Ricklefs FL, Maire CL, Reimer R, DührsenL, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K. Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. Journal of Extracellular Vesicles, 8:1, 1588555, DOI: 10.1080/20013078.2019.1588555 11.0
4. Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn PA, Thalmann S, Welsh JA, Probst, Guerin C, Boulanger CM, Jones JC, Hanenberg H, Erdbrügger U, Lannigan J, Ricklefs FL, El-Andaloussi S, Giebel B. Optimisation of imaging flow cytometry forthe analysis of single extracellular vesicles byusing fluorescence-tagged vesicles as biologicalreference material. Journal of Extracellular Vesicles, 8:1, 1587567, DOI:10.1080/20013078.2019.1587567 11.0
5. Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles, 2019 Apr 29, 8(1): 1609206, DOI:10.1080/20013078.2019.1609206 11.0
6. Kordelas L, Schwich E, Dittrich R, Horn PA, Beelen DW, Börger V, Giebel B, Rebmann V. Individual Immune-Modulatory Capabilities of MSC-Derived Extracellular Vesicle (EV) Preparations and Recipient-Dependent Responsiveness.Int. J. Mol. Sci. 2019, 20(7), 1642; 4.1
7. Kopp M, Aufderhorst UW, Alt M, Dittmer U, Eis-Hübinger A, Giebel B, Roggendorf M, Epple M, Krawczyk A. Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine. Nanomedicine. 2019 Feb;16:138-148. doi: 10.1016/j.nano.2018.12.002. 4.7
8. Frey UH, Klaassen M, Ochsenfarth C, Murke F, Thielmann M, Kottenberg E, Kleinbongard P, Klenke S, Engler A, Heusch G, Giebel B, Peters J. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro‐RNA signature in CABG patients. Acta Anaesthesiol Scand. 2019 Apr;63(4):483-492. doi: 10.1111/aas.13296 2.2
9. Giebel B, Hermann DM. Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke. Ann Transl Med. 2019 May; 7(9): 188. 3.6
10. Sody S, Uddin M, Grüneboom A, Görgens A, Giebel B, Gunzer M, Brandau S. Distinct spatio-temporal dynamics of tumor-associated neutrophils in small tumor lesions. Front Immunol. 2019 Jun 25; 10: 1419. 4.7
11. Radtke S, Görgens A, da Conceição Castro SV, Kordelas L, Köninger A, Dürig J, Möllmann M, Horn PA, Giebel B. Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice. Sci Rep. 2019 Sep 9; 9(1): 12914. 4.0
12. Ricklefs FL, Maire CL, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K. Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019 Mar 21; 8(1): 1588555. 11.0
13. Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn PA, Thalmann S, Welsh JA, Probst C, Guerin C, Boulanger CM, Jones JC, Hanenberg H, Erdbrügger U, Lannigan J, Ricklefs FL, El-Andaloussi S, Giebel B. Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material. J Extracell Vesicles. 2019 Mar 21; 8(1): 1587567. 11.0

Publications 2018

2018 Impact Factor  
1. Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C. Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome. Haematologica. 2018 Jan 11. pii: haematol.2017.167288. doi: 10.3324/haematol.2017.167288. [Epub ahead of print] PMID: 29326122 7.5  
2. Thorsten R. Doeppner, Mathias Bähr, Bernd Giebel and Dirk M. Hermann. Immunological and non-immunological effects of stem cell-derived extracellular vesicles on the ischaemic brain. Ther Adv Neurol Disord. 2018 Jul 26;11:1756286418789326. doi: 10.1177/1756286418789326. eCollection 2018 PMID: 30083231 3.5  
3. Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel, B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A. Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front Immunol. 2018 Jun 13;9:1326. doi: 10.3389/fimmu.2018.01326. eCollection 2018. PMID: 29951064 4.7  
4. Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, Rebmann V, Durst S, Jansen S, Bremer M, Behrmann E, Singer BB, Jastrow H, Kuhlmann JD, El Magraoui F, Meyer HE, Hermann DM, Opalka B, Raunser S, Epple M, Horn PA, Giebel, B. Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J Extracell Vesicles. 2018 Oct 17 7(1):1528109. doi: 10.1080/20013078.2018.1528109. eCollection 2018. PMID: 30357008 11.0  
5. E. M. Hummel, E. Hessas, S. Müller, T. Beiter, M. Fisch, A. Eibl, O. T. Wolf, B. Giebel, P. Platen, R. Kumsta and D. A. Moser. Cell-free DNA release under psychosocial and physical stress conditions. Translational Psychiatry (2018) 8:236. doi: 10.1038/s41398-018-0264-x. PMID: 30374018 5.1  
6. Ulrich H. Frey, Marina Klaassen, Crista Ochsenfarth, Florian Murke, Matthias Thielmann, Eva Kottenberg, Petra Kleinbongard, Stefanie Klenke, Andrea Engler, Gerd Heusch, Bernd Giebel, Jürgen Peters. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro‐RNA signature in CABG patients. Acta Anaesthesiol Scand.2018;1–10.. doi: 10.1111/aas.13296. 2.2  
7. Clotilde Théry, Kenneth W Witwer, …, Bernd Giebel, …, Davide Zocco & Ewa K Zuba-Surma. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles, 7:1, 1535750, DOI: 10.1080/20013078.2018.1535750. 11.0  

Publications 2017

2017 Impact Faktor
1. Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, Lim SK. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Transl Med. 2017 Aug;6(8):1730-1739. doi: 10.1002/sctm.17-0055. Epub 2017 Jul 17. 4.0
2. Giebel B. On the function and heterogeneity of extracellular vesicles. Ann Transl Med. 2017 Mar;5(6):150. doi: 10.21037/atm.2017.02.14.  
3. EV-TRACK Consortium, Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TA, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-'t Hoen EN, O'Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen JV, Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, van der Grein S, Van Goethem A, van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods. 2017 Feb 28;14(3):228-232. doi: 10.1038/nmeth.4185. 25.1
4. O'Driscoll L, Stoorvogel W, Théry C, Buzas E, Nazarenko I, Siljander P, Yáñez-Mó M, Fais S, Giebel B, Yliperttula M. European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD). Eur J Pharm Sci. 2017 Feb 15;98:1-3. doi: 10.1016/j.ejps.2017.01.003. 3.7
5. Giebel B, Helmbrecht C. Methods to Analyze EVs. Methods Mol Biol. 2017;1545:1-20.  
6. Börger V, Bremer M, Ferrer-Tur R, Gockeln L, Stambouli O, Becic A, Giebel B. Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents. Int J Mol Sci. 2017 Jul 6;18(7). 3.2
7. Bauer D, Alt M, Dirks M, Buch A, Heilingloh CS, Dittmer U, Giebel B, Görgens A, Palapys V, Kasper M, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Krawczyk A. A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease. Front Microbiol. 2017 Oct 31;8:2115. doi: 10.3389/fmicb.2017.02115. eCollection 2017. PMID: 29163407 4.0
8. Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C. Enforced GFI1 expression impedes human and murine leukemic cell growth. Sci Rep. 2017 Nov 16;7(1):15720. doi: 10.1038/s41598-017-15866-9. PMID: 29147018 4.2
9. Doeppner TR, Bähr M, Hermann DM, Giebel B. Concise Review: Extracellular Vesicles Overcoming Limitations of Cell Therapies in Ischemic Stroke. Stem Cells Transl Med. 2017 Nov;6(11):2044-2052. doi: 10.1002/sctm.17-0081. Epub 2017 Sep 23. Review. PMID: 28941317 4.0
10. Corso G, Mäger I, Lee Y, Görgens A, Bultema J, Giebel B, Wood MJA, Nordin JZ, Andaloussi SE. Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography. Sci Rep. 2017 Sep 14;7(1):11561. doi: 10.1038/s41598-017-10646-x. 4.2
11. Drommelschmidt K, Serdar M, Bendix I, Herz J, Bertling F, Prager S, Keller M, Ludwig AK, Duhan V, Radtke S, de Miroschedji K, Horn PA, van de Looij Y, Giebel B, Felderhoff-Müser U. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain Behav Immun. 2017;60:220-32  
12. Giebel B, Kordelas L., Börger V. Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles. Stem cell investigation. 2017 doi: 10.21037/sci.2017.09.06 PMID: 29167805  

Publications 2016

2016 Impact Faktor
1. Nardi Fda S, König L, Wagner B, Giebel B, Santos Manvailer LF, Rebmann V. Soluble monomers, dimers and HLA-G-expressing extracellular vesicles: the three dimensions of structural complexity to use HLA-G as a clinical biomarker. HLA. 2016 Sep; 88(3):77-86  
2. Görgens A, Murke F, Kordelas L, Giebel B. Lost in Transplantation? Unexpected shift from multipotent to late lymphomyeloid hematopoietic stem and progenitor cells in patients 1 year after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2016 Aug; 51(8):1073-5 3.6
3. Botezatu L, Michel LC, Helness A, Vadnais C, Hönes JM, Makishima H, Robert F, Vassen L, Aniththa Thivakaran1, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T,Khandanpour C. Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML. Exp. Hematol. 2016; 44(8):713-26 2.5
4. Ophelders DRMG, Wolfs TGAM, Jellema RK, Zwanenburg A, Andriessen P, Delhaas T, Ludwig AK, Radtke S, Peters V, Janssen L, Giebel B and Kramer BW. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia. Stem Cells Transl Med. 2016 Jun; 5(6): 754-63 5.7
5. Hombach AA, Görgens A, Chmielewski M, Murke F, Kimpel J, Giebel B, Abken H. Superior therapeutic index in lymphoma therapy: CD30+ CD34+ hematopoietic stem cells resist a chimeric antigen receptor (CAR) T cell attack. Mol Ther. 2016 Aug; 24(8): 1423-34 6.2
6. Nel I, Gauler TC, Bublitz K, Lazaridis L, Goergens A, Giebel B, Schuler M, Hoffmann AC. Circulating Tumor Cell Composition in Renal Cell Carcinoma. PLoS One. 2016; 11 (4): e0153018 3.5
7. Fais S, O’Driscoll L, Borras FE, Buzas E, Camussi G, Cappello F, Carvalho J, Cordeiro da Silva A, Del Portillo H, El Andaloussi S, Ficko Trček T, Furlan R, Hendrix A, Gursel I, Kralj-Iglic V, Kaeffer B, Kosanovic M, Lekka ME, Lipps G, Logozzi M, Marcilla A, Sammar M, Llorente A, Nazarenko I, Oliveira C, Pocsfalvi G, Rajendran L, Raposo G, Rohde E, Siljander P, van Niel G, Vasconcelos MH, Yáñez-Mó M, Yliperttula ML, Zarovni N, Zavec AB and Giebel B. Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine. ACS Nano. 2016 12.9
8. Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski J, Möröy T, Khandanpour C. GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016 Feb 5. doi: 10.1038/leu.2016.11. 10.4
9. Zeuner MT, Patel K, Denecke B, Giebel B, Widera D. Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles. J Transl Med. 2016 Feb. 3.9
10. Börger V, Bremer M, Görgens A, Giebel B. Mesenchymal stem/stromal cell-derived extracellular vesicles as a new approach in stem cell therapy. ISBT Sci Ser. 2016; 11 (1): 228–234  
11. Radtke S, Görgens A, Liu B, Horn PA & Giebel B. Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitors cells. Cell Cycle. 2016 Feb 16; 15(4): 540-5 5.0
12. König L, Kasimir-Bauer S, Hoffmann O, Bittner AK, Wagner B, Manvailer LF, Schramm S, Bankfalvi A, Giebel B, Kimmig R, Horn PA, Rebmann V. The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients. Hum Immunol. 2016; 77(9):791–99 2.3

Publications 2015

2015 Impact Faktor
1. Denecke B, Horsch LD, Radtke S, Fischer JC, Horn PA, Giebel B. Human endothelial colony-forming cells expanded with an improved protocol are a useful endothelial cell source for scaffold-based tissue engineering.J Tissue Eng Regen Med. 2015; 9 (11): E84-97 5.2
2. Murke F, Castro SVC, Giebel B, Görgens A. Concise Review: Asymmetric Cell Divisions in Stem Cell Biology. Symmetry. 2015; 7: 2025-2037 0.8
3. Loeffek S, Ullrich N, Görgens A, Murke F, Eilebrecht M, Menne C, Giebel B, Schadendorf D, Singer BB, Helfrich I. CEACAM1-4L promotes anchorage-independent growth in melanoma. Front Oncol. 2015; 5: 234  
4. Görgens A, Horn PA. From Basic Biology to Engineering and Clinical Translation of Stem Cells. Cellular Reprogramming. December 2015; 17 (6): 415-418 1.8
5. Börger V, Görgens A, Rohde E, Giebel B. Therapeutisches Potenzial von extrazellulären Vesikeln aus mesenchymalen Stamm- bzw. Stromazellen. Transfusionsmedizin. 2015; 5: 131–137  
6. Doeppner TR, Herz J, Gorgens A, Schlechter J, Ludwig AK, Radtke S, de Miroschedji K, Horn PA, Giebel B and Hermann DM. Extracellular vesicles improve post-stroke neuroregeneration and prevent post-ischemic immunosuppression. Stem Cells Transl Med. 2015; 4 (10): 1131-43 5.7
7. Görgens A, Giebel B. Wie unser Blut entsteht – neue Erkenntnisse zur Hämatopoese. BIOspektrum. 2015; 21 (3): 290-293  
8. Yáñez-Mó M, Siljander PRM, Andreu Z, [...], Giebel B, [...], Vasconcelos MH, Wauben MHM, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4: 27066  
9. Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M. Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3. Stem Cells Dev. 2015 May 11 [Epub] 4.2
10. Radtke S, Görgens A, Kordelas L, Schmidt M, Kimmig KR, Köninger A, Horn PA, Giebel B. CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants. Br. J. Haematol. 2015; 169 (6):868-78 5.0
11. Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody PLoS ONE. 2015; 10(1): e0116800 3.5
12. Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O'Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BW, Wauben M, Andaloussi SE, Théry C, Rohde E, Giebel B. Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper J Extracell Vesicles. 2015 Dec 31;4:30087. doi: 10.3402/jev.v4.30087. eCollection 2015  
13. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933-9. doi: 10.1093/bioinformatics/btu741. Epub 2014 Nov 10. PMID: 25388151  

Publications 2014

1. Radtke, S., Giebel, B., Wagner, W., and Horn, P.A. Platelet lysates and their role in cell therapy. ISBT Science Series. 2014; 9(1): 193-7  
2. Brandau S, Jakob M, Bruderek K, Bootz F, Giebel B, Radtke S, Mauel K, Jäger M, Flohé SB, Lang S. Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes. PLoS One. 2014; 9(11): e114201 3.5
3. Müller CR, Mytilineos J, Ottinger H, Arnold R, Bader P, Beelen D, Bornhäuser M, Dreger P, Eiermann T, Einsele H, Faé I, Fischer G, Füssel M, Holler E, Holzberger G, Horn PA, Kröger N, Lindemann M, Seidl C, Spriewald B, Süsal C, Blasczyk R, Finke J. Deutscher Konsensus 2013 zur immungenetischen Spenderauswahl für die allogene Stammzelltransplantation. Transfusionsmedizin. 2014; 4: 190-6  
4. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, [...], Giebel B, [...], Zeidler R, Gho YS. EVpedia: A Community Web Portal for Extracellular Vesicles Research. Bioinformatics. 2014; 31 (6): 933-9 4.6
5. Malyar NM, Radtke S, Malyar K, Arjumand J, Horn PA, Kröger K, Freisinger E, Reinecke H, Giebel B, Brock FE. Autologous Bone Marrow Mononuclear Cell Therapy Improves Symptoms in Patients with End-Stage Peripheral Arterial Disease and Reduces Inflammation Associated Parameters. Cytotherapy. 2014; 16(9): 1270-9 3.3
6. Kordelas L, Rebmann V, Ludwig AK, Radtke S, Ruesing J, Doeppner TR, Epple M, Horn PA, Beelen DW, Giebel B. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia. 2014; 28(4): 970-3 10.2
7. Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014; 16(2): 170-80 3.3
8. Görgens A, Ludwig AK, Möllmann M, Krawczyk A, Dürig J, Hanenberg H, Horn PA, Giebel B. Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages. Stem Cell Reports. 2014 Dec 9;3(6):1058-72. doi: 10.1016/j.stemcr.2014.09.016. Epub 2014 Oct 23. Erratum in: Stem Cell Reports. 2015 Jul 14;5(1):154-5. PMID: 25448068  

Publications 2013

1. Görgens A, Radtke S, Horn PA, Giebel B. New Relationships of Human Hematopoietic Lineages Facilitate Detection of Multipotent Hematopoietic Stem and Progenitor Cells. Cell Cycle. 2013; 12(22): 3478-82 5.2
2. Muturi HT, Dreesen, JD, Nilweski E, Jastrow H, Giebel B, Ergun S, Singer BB. Tumor and Endothelial Cell-Derived Microvesicles Carry Distinct CEACAMs and Influence T-Cell Behavior. PLOS One. 2013; 8(9): e74654 3.7
3. Görgens A, Radtke S, Moellmann M, Cross M, Duerig J, Horn PA, Giebel B. Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages. Cell Reports. 2013; 3(5): 1539-52 8.4
4. Krawczyk A, Arndt MAE, Grosse-Hovestc L, Weichert W, Giebel B, Dittmer U, Hengel H, Jäger D, Schneweis KE, Eis-Hübingerg AM, Roggendorf M, Krauss J. Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody. Proc Natl Acad Sci USA. 2013; 110(17): 6760-5 9.7
5. Schilling B, Sucker A, Griewank K, Zhao F, Weide B, Görgens A, Giebel B, Schadendorf D, Paschen A. Vemurafenib reverses immunosuppression by myeloid derived suppressor cells. Int J Cancer. 2013; 133(7): 1653-63 5.4



Gortner L, Felderhoff-Müser U, Monz D, Bieback K, Klüter H, Jellema R, Kramer BW, Keller M, Reiss I, Horn PA, Giebel B (2012)
Regenerative therapies in neonatology: clinical perspectives
Klin Pediatr


 Doeppner TR, Ewert TAS, Tönges L, Herz J, Zechariah A, ElAli S, Ludwig A-K, Giebel B, Nagel F, GPH, Weise J, Hermann DM, Bähr M (2012)  Transduction of Neural Precursor Cells with TAT-Hsp70 Chaperone: Therapeutic Potential Against Ischemic Stroke After Intrastriatal and Systemic Transplantation
Stem Cells


 Goergens, A., Beckmann, J., Ludwig, A.-K., Möllmann, M., Dürig, J., Horn, P. A., Rajendran, L., & Giebel, B. (2012)  Lipid raft redistribution and morphological cell polarization are separable processes providing a basis for hematopoietic stem and progenitor cell migration
International Journal of Biochemistry and Cell Biology (2012), doi:10.1016/j.biocel.2012.03.020 


 Giebel B, Wodarz A (2012)  Notch signaling: numb makes the difference
Curr Biol. 2012 Feb 21;22(4):R133-5 




 Ludwig AK, Giebel B (2011)  Exosomes: small vesicles participating in intercellular communication
Int J Biochem Cell Biol. 2012 Jan;44(1):11-5 


 Radtke S, Horn PA (2011)  Cells, niche, fate: meeting report on the 6th International Meeting of the Stem Cell Network North Rhine Westphalia
Cell Reprogram. 2011 Oct;13(5):381-4 


 Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B (2011)  Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):146-50 



  Hemeda H, Jakob M, Ludwig A, Giebel B, Lang S, Brandau S.  (2010)
  Interferon-gamma and Tumor Necrosis Factor-alpha Differentially Affect Cytokine Expression and Migration Properties of Mesenchymal Stem Cells
  Stem Cells Dev. 2010 May;19(5):693-706



  Rajendran L, Beckmann J, Magenau A, Boneberg EM, Gaus K, Viola A, Giebel B, Illges H.  (2009)
  Flotillins are involved in the polarization of primitive and mature hematopoietic cells
  PLoS One e8290:




  Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart LA, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A, Giebel B, Wischhusen J, Reifenberger G, Hau P  (2008)
  Temozolomide preferentially depletes cancer stem cells in glioblastoma
  Cancer Res. 68(14): 5706-15


    Giebel B, Punzel M  (2008)
  Lineage development of hematopoietic stem and progenitor cells.
  Biol Chem 389(7): 813-24


    Giebel B, Bruns I.  (2008)
  Self-renewal versus differentiation in hematopoietic stem and progenitor cells: a focus on asymmetric cell divisions.
  Curr Stem Cell Res Ther 3(1): 9-16


    Giebel B  (2008)
  Cell polarity and asymmetric cell division within human hematopoietic stem and progenitor cells.
  Cells Tissues Organs 188(1-2): 116-26




    Giebel B, Beckmann J.  (2007)
  Asymmetric cell divisions of human hematopoietic stem and progenitor cells meet endosomes.
  Cell Cycle 6(18): 2201-4


  Feldhahn N, Henke N, Melchior K, Duy C, Soh BN, Klein F, von Levetzow G, Giebel B, Li A, Hofmann WK, Jumaa H, Müschen M.  (2007)
  Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.
  J Exp Med 204(5): 1157-66


  Beckmann J, Scheitza S, Wernet P, Fischer JC, Giebel B. (2007)
  Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins.
  Blood 109(12): 5494-501




  von Levetzow G, Spanholtz J, Beckmann J, Fischer J, Kögler G, Wernet P, Punzel M, Giebel B. (2006)
  Nucleofection, an efficient nonviral method to transfer genes into human hematopoietic stem and progenitor cells.
  Stem Cells Dev 15(2): 278-85


    Giebel B, Wodarz A.  (2006)
  Tumor suppressors: control of signaling by endocytosis.
  Curr Biol 16(3): R91-2


  Bracker TU, Giebel B, Spanholtz J, Sorg UR, Klein-Hitpass L, Moritz T, Thomale J.  (2006)
  Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.
  Stem Cells 24(3): 722-30




    Giebel B, Corbeil D, Beckmann J, Höhn J, Freund D, Giesen K, Fischer J, Kögler G, Wernet P.  (2004)
  Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells.
104(8 Blood 104(8: 2332-8


  Schneider EM, Torlakovic E, Stühler A, Diehl V, Tesch H, Giebel B.  (2004)
  The early transcription factor GATA-2 is expressed in classical Hodgkin\\\'s lymphoma.
  J Pathol 204(5): 538-45