Core "Ischemia/reperfusion and angiogenesis"


Injury due to insufficient perfusion and/or due to reperfusion of a previously ischemic tissue (ischemia-reperfusion injury) is the underlying cause or decisively involved in many diseases including heart attack, stroke or various kinds of shock. Ischemia-reperfusion injury is central concerning two of the core areas of the Faculty of Medicine, the cardiovascular system and transplantation, but is also related to the other research focus oncology.

The course will not only cover mechanisms and consequences of cell and tissue injury during ischemia-reperfusion of various organs including heart, brain, intestine, liver, and muscle but also regenerating processes following ischemia-reperfusion such as angiogenesis, and protective/therapeutic measures such as pre- and postconditioning and pharmacological treatment.

Lectures and seminars will be held on mechanisms of apoptotic and necrotic cell death, signal transduction cascades, inflammatory responses, growth factors, local progenitor and stem cells, and on strategies used to prevent cell and tissue injury induced by ischemia-reperfusion in different organs and to support regeneration.

Members of the course will get the opportunity to obtain insights into subcellular (mitochondrial), cellular and small/large animal models of ischemia-reperfusion injury and to get in contact with clinical and translational research on the subject. A wide analytical spectrum will be presented including e.g. cell and molecular biology (analysis of cellular dedifferentiation and transcriptional and post-transcriptional regulation), conventional histology, immune staining (immunofluorescence), electron microscopy, confocal 3D imaging, protein-protein interaction analysis, angiogenesis assays, and in vivo imaging.