Publikationen


2021

 

Adamczyk A, Pastille E, Kehrmann J, Vu VP, Geffers R, Wasmer MH, Kasper S, Schuler M, Lange CM, Muggli B, Rau TT, Klein D, Hansen W, Krebs P, Buer J,Westendorf AM. GPR15 facilitates recruitment of regulatory T cells to promote colorectal Cancer. Cancer Res. 2021 Mar16:canres.2133.2020. doi:10.1158/0008-5472.CAN-20-2133.Online ahead of print.


Palmieri V, Ebel JF, Ngo Thi Phuong N, Klopfleisch R, Vu VP, Adamczyk A, Zöller J, Riedel C, Buer J, Krebs P, Hansen W, Pastille E, Westendorf AM. Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity.  Mucosal Immunol. 2021 Mar 2. doi: 10.1038/s41385-021-00386-7. Online ahead of print.


Moshkelgosha S, Verhasselt HL, Masetti G, Covelli D, Biscarini F, Horstmann M, Daser A, Westendorf AM, Jesenek C, Philipp S, Diaz-Cano S, Banga JP, Michael D, Plummer S, Marchesi JR, Eckstein A, Ludgate M, Berchner-Pfannschmidt U; and the INDIGO consortium. Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease. Microbiome. 2021 Feb 16;9(1):45. doi: 10.1186/s40168-020-00952-4.

 

Wuelling M, Neu C, Thiesen AM, Kitanovski S, Cao Y, Lange A, Westendorf AM, Hoffmann D, Vortkamp A.  Epigenetic mechanisms mediating cell state transitions in chondroytes. J Bone Miner Res. 2021 Feb 3. doi: 10.1002/jbmr.4263.

 

Knuschke T, Kollenda S, Wenzek C, Zelinskyy G, Steinbach P, Dittmer U, Buer J, Epple M, Westendorf AM. A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells. mBio. 2021 Feb 2;12(1):e02121-20. doi: 10.1128/mBio.02121-20

 

 

2020

 

Hansen W, Luppus S, Barthel R, Chang DI, Broemstrup J, Zwarg T, Shibata, Westendorf AM, Buer J, Scherbaum N. Heroin-assisted treatment of heroin-addicted patients normalizes regulatroy T cells but does not restore CD4+ T cell Proliferation. Addict Biol. 2020 Dec 17:e 12998. doi: 10.1111/adb 12998. 

 

Meurer T, Crivello P, Metzing MF, Kester M, Megger DA, Chen W, van Veelen PA, van Balen P, Westendorf A, Homa G, Layer SE, Turki AT, Griffioen M, Horn PA, Sitek B, Beelen DW, Falkenburg JHF, Arrieta-Bolaños E, Fleischhauer K.  Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM. Blood, 2020. PMID: 33025005 URL  - https://www.ncbi.nlm.nih.gov/pubmed/33025005

 

Zöller J, Ebel J-F, Khairnar V, Schmitt V, Klopfleisch R, Meiners J, Seiffert V, Hansen W, Buer J, Singer BB, Lang KS, Westendorf AM. CEACAM1 regulates CD8 T cell immunity and protects from severe patholgy during Citrobacter rodentium induced colitisJune 10, 2020 . Gut Microbes https//doi.org/10.1080/19490976.2020.1775464

 

Liedtke K, Alter C, Günther A, Hövelmeyer N, Klopfleisch R, Naumann R, Wunderlich FT, Buer J, Westendorf AM, Hansen W. Endogenous CD83 Expression in CD4+   Conventional T Cells Controls Inflammatory Immune Responses. J Immunol April 27, 2020, ji2000042; DOI: https//doi.org/10.4049/jimmunol.2000042

 

Kollenda SA, Klose J, Knuschke T, Sokolova V, Schmitz J, Staniszewska M, Costa PF, Herrmann K, Westendorf AM, Fendler WP, Epple M. In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral and soft tissue administration in mice investigated by small animal PET/CT. Acta Biomater 2020 Apr 3. pii: S1742-7061 (20)30172-0. doi:10.1016/j actbio.2020.03.031 

 

David P, Drabczyk-Pluta M, Pastille E, Knuschke T, Werner T, Honke N, Megger DA, Akhmetzyanova I, Shaabani N, Eyking-Singer A, Cario E, Kershaw O, Gruber AD, Tenbusch M, Dietze KK, Trilling M, Liu J, Schadendorf D, Streeck H, Lang KS, Xie Y, Zimmer L, Sitek B, Paschen A, Westendorf AM, Dittmer U, Zelinskyy G. Combination immunotherapy with ant-PD-LL 1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology. PLoS Pathog. 2020 Mar 30;16(3):e1008340. doi: 10.1371/journal.

 

Scheffel F, Knuschke T,  Otto L,  Kollenda S,   Sokolova V, Cosmovici  C, Buer J, Timm J, Epple M and  Westendorf  AM. Eective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccines (Basel) Delivery System. Vaccines 2020 Mar 1;8(1). pii: E110. doi: 10.3390/vaccines8010110.<//span> 

 

  

2019

 

Kehrmann J, Effenberg L, Wilk C, Schoemer D, Ngo Thi Phuong N, Adamczyk A, Pastille E, Scholtysik R, Klein-Hitpass L, Klopfleisch R, Westendorf AM, Buer J. Depletion of Foxp3+ regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome. Immunology. 2019 Nov 22. doi: 10.1111/imm.13158.

Dickow J, Francois S, Kaiserling RL, Malyshkina A, Drexler I, Westendorf AM, Lang KS, Santiago ML, Dittmer U, Sutter K.  Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses. Front Immunol. 2019 Sep 24;10:2255. doi: 10.3389/fimmu.2019.02255. eCollection 2019.

 

Malewicz NM, Walstein K, Heine T, Engler A, Bick A, Cox L, Dötsch A, Westendorf AM, Horn PA, Lindemann M, Peters J, Schäfer ST.  Early suppression of peripheral mononuclear blood cells in sepsis in response to stimulation with cytomegalovirus, OKT3, and pokeweed mitogen.J Appl Physiol (1985) 2019 Sep 23. doi: 10.1152/japplphysiol.00438.2019. [Epub ahead of print]

 

Hose M, Günther A, Abberger H, Begum S, Korencak M, Becker KA, Buer J, Westendorf AM, Hansen W. T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection. Front Immunol, 2019 vol. 10 pp. 1225

 

Meiners J, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker K.A., Zöller J, Hose M, Kleuser B, Hermann D M, Kolesnick R., Buer J, Hansen W, Westendorf A. M. Intestinal acid sphingomyelinase protects from severe pathogen-driven colities. Front Immunol. 2019 June 19; doi:10.3389/fimmu.2019.01386

 

Pastille E, Wasmer MH, Adamczyk A, Vu VP, Mager LF, Phuong NNT, Palmieri V, Simillion C, Hansen W, Kasper S, Schuler M, Muggli B, McCoy KD, Buer J, Zlobec I, Westendorf AM, Krebs P. The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. Mucosal Immunol. 2019 Jun 5. doi: 10.1038/s41385-019-0176-y. [Epub ahead of print]

 

Heße C, Kollenda S, Rotan O, Pastille E, Adamczyk A, Wenzek C, Hansen W, Epple M, Buer J, Westendorf AM, Knuschke T. A tumor-peptide based nanoparticle vaccine elicits efficient tumor growth control in anti-tumor immunotherapy. Mol Cancer Ther. 2019 Apr 8. pii: molcanther.0764.2018. doi: 10.1158/1535-7163.

 

Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang S, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, v Stein J, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A , Gunzer M. A network of trans-cortical capillaries as mainstay for blood circulation in long bones. Nature Metabolism volume 1, pages236–250 (2019)

 

 

 

2018

 

Sokolova V, Loza K, Knuschke T, Heinen-Weiler J, Jastrow H, Hasenberg M, Buer J, Westendorf AM, Gunzer M, Epple M. A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells. Acta Biomater. 2018 Sep 18. pii: S1742-7061(18)30543-9. doi: 10.1016/j.actbio.2018.09.026. [Epub ahead of print]


Thiel J, Alter C, Luppus S, Eckstein A, Tan S, Führer D, Pastille E, Westendorf AM, Buer J, Hansen W. MicroRNA-183 and microRNA-96 are associated with autoimmune responses by regulating T cell activation. J Autoimmun. 2018 Sep 7. pii: S0896-8411(18)30302-0. doi: 10.1016/j.jaut.2018.08.010. [Epub ahead of print]

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS. CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection. Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2.
 
Knuschke T, Rotan O, Bayer W, Kollenda S, Dickow J, Sutter K, Hansen W, Dittmer U, Lang KS, Epple M, Buer J, Westendorf AM. Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection. Front Immunol. 2018 Apr 23;9:614

Adamczyk A, Westendorf AM. Cancer, drugs, and bugs-Bacteriotherapy on the rise? J Leukoc Biol. 2018 Apr 15. doi: 10.1002/JLB.5CE0118-018R. [epub haed of print]

Lapuente D,  Storcksdieck Genannt Bonsmann M, Maaske A, Stab V, Heinecke V, Watzstedt K, Heß R, Westendorf AM, Bayer W, Ehrhardt C, Tenbusch M. IL-1β as mucosal vaccine adjuvant: the specific induction of tissue-resident memory T cells improves the heterosubtypic immunity against influenza A viruses. Mucosal Immunol. 2018 Mar 15. doi: 10.1038/s41385-018-0017-4.


2020 Sep 6;blood.2020008464.

2017

Smirnov A, Pohlmann S, Nehring M, Ali S, Mann-Nüttel R, Scheu S, Antoni AC, Hansen W, Büttner M, Gardiasch M, Westendorf AM, Wirsdörfer F, Pastille E, Dudda M, Flohé S. Sphingosine 1-phosphate-and CCR2-dependent activation of CD4+ plasmacytoid dendritic cells in the bone marrow contributes to signs of Sepsis-Induced immunosuppression. Front. Immunol. 2017 Nov 23: doi.org/10.3389/fimmu.2017.01622.

 

Ueffing K, Abberger H, Westendorf AM, Matuschewski K, Buer J, Hansen W. Conventional CD11chigh Dendritic Cells Are Important for T Cell Priming during the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later Time Points. Front Immunol. 2017 Oct 16;8:1333. doi: 10.3389/fimmu.2017.01333. eCollection 2017.


Sokolova V, Shi Z, Huang S, Du Y, Kopp, Frede A, Knuschke T, Buer J, Yang D, Wu J, Westendorf AM, Epple M. Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo b calium phosphate nanoparticles leads to a pronounced immunostimulation.  Acta Biomater. 2017 Sep 27. pii: S1742-7061(17)30609-8.doi: 10.1016/j.actbio. 2017.09.037. 


Pastille E, Frede A, McSorley H, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM. Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PlosPathogens 2017; 13 (9): e1006649. doi: 10.1371/Journal.ppat.1006649.

 

Schoemer D, Adamczyk A, Pastille E, Westendorf AM, Buer J, Kerhmann J: Analysis of the gut microbiome in Foxp3+Regulatory T cell depleted mice.Eur J Immunol. 2017;47 2: 67-67.


Frede A, Neuhaus B, Knuschke T, Wadwa M, Kollenda S, Klopfleisch R, Hansen W, Buer J,Bruder D,Epple M,Westendorf AM. Local delivery of siRNA-loaded calcium Phosphate nanopartiles abates pulmonary Inflammation. Nanomedicine 2017; 13: 2395-2403. doi: 10.1016/j.nano.2017.08.001.


Sucker A, Zhao F, Pieper N, Heeke C, Maltaner R, Stadtler N, Real B, Bielefeld N, Howe S, Weide B, Gutzmer R, Utikal J, Loquai C, Gogas H, Klein-Hitpass L, Zeschnigk M, Westendorf AM, Trilling M, Horn S, Schilling B, Schadendorf D, Griewank KG, Paschen A. Acquired IFNɤ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions. Nat Commun. 2017 May 31;8:15440. doi: 10.1038/ncomms15440.

Van der Meer SB, Knuschke T, Frede A, Schulze N, Westendorf AM, Epple M. Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo. Acta Biomater. 2017 May 26. pii: S1742-7061(17)30340-9. doi: 10.1016/j.actbio.2017.05.049.


Adamczyk A, Gageik D, Frede A, Pastille E, Hansen W, Rueffer A, Buer J, Büning J, Langhost J, Westendorf AM. Differential expression of GPR15 on T cells during ulcerative colitis. JCI Insight. 2017; 2(8). pii: 90585. doi: 10.1172/jci.insight.90585.

Westendorf AM, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Pastille E, Jendrossek V. Hypoxia Enhances Immunosuppression by Inhibiting CD 4+ Effector T Cell Function and Promoting Treg Activity. Cell Physiol Biochem 2017; 41:1271-1284. doi: 10.1159/000464429.

Loevenich K, Ueffing K, Abel S, Hose M, Matuschewski K, Westendorf AM, Buer J, Hansen W. DC-Derived IL-10 Modulates Pro-inflammatory Cytokine production and Promotes Induction of CD4+IL-10+ Regulatory T cells during Plasmodium yoelii Infection. Front Immunol. 2017; 8:152. doi: 10.3389/fimmu. 2017.00152

Saeedghalati M, Farahpour F, Budeus B, Lange A, Westendorf AM, Seifert M, Küppes R, Hoffmann D. Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes. PLoS Comput Biol. 2017 Jan 23;13(1):e1005362. doi:10.1371/Journal.pcbi.1005362 eCollection 2017 Jan.

 

 

2016

 

Gamrad L, Rehbock C, Westendorf AM, Buer J, Hansen W. Efficient nucleic acid delivery to murine regulatory T cells by gol nanoparticle conjugates Sci Rep: 28709.


Wadwa M, Klopfleisch R, Buer J, Westendorf AM. Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice.  Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. doi: 10.1556/1886.2015.00048. eCollection 2016 Mar. Select item 269213344.

 

Wirsdörfer F, de Leve S, Cappuccini  F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschk M, Jendrossek V. Extracellular Adenosine Production by ecto-5`-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.Cancer Res. 2016 May 15; 76 (10):3045-56. doi: 10.1158/0008-5472. CAN-15-2310.

 

Wirsdörfer F, Bangen JM, Pastille E, Schmitz D, Flohé S, Schumak B, Flohé SB Dentritic Cell-Like Cells Accumumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses only upon a Microbial Challenge. PLoS One. 2016 May 19; 11 (5): e0155870. doi: 10.1371/journal.pone.0155870. eCollection 2016.

 

Knuschke T, Rotan O, Bayer W, Sokolova V, Hansen W, Sparwasser T, Dittmer U, Epple M, Buer J, Westendorf AM. Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology.2016 Apr 14;13:24. doi: 10.1186/s12977-016-0258-9.

 

Abel S, Ueffing K, Tatura R, Hutzler M, Hose M, Matuschewski K, Kehrmann J, Westendorf AM, Buer J, Hansen W. Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cellsImmunology. 2016 Jun;148(2):197-205. doi: 10.1111/imm.12602. Epub 2016 Mar 23. PMID:26932746

 

Neuhaus B, Tosun B,  Rotan O; Frede A.;  Westendorf AM; Epple M. Nanoparticles as transfection agents: a comprehensive study with ten different cell lines. RSC Adv., 2016, 6, 18102.  

 

Schäfer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schönborn, N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T Kurts C, Frede S, Peters J, Limmer A, Mitochondrial DNA: an Endogenous Trigger for Immune Paralysis. Anesthesiology. 2016 Jan 15.

 

Wadwa M, Klopfleisch R, Adamczyk A, Frede A, Pastille E, Mahnke K, Hansen W, Geffers R, Lang KS, Buer J, Büning J, Westendorf AM. Mitochondrial DNA: an Endogenous Trigger for Immune Paralysis. Mucosal Immunol. 9:1263-77. 

 

Frede A, Neuhaus B, Klopfleisch R, Walker C, Buer J, Müller W, Epple M, Westendorf AM. Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles amerliorates intestinal inflammation in vivo. J Control Release 2016 222:86-96

 

 

2015

 

Wirsdörfer F, Bangen JM, Pastille E, Hansen W. and Flohé SB. 2015. Breaking the cooperation between bystander T-cells and Natural Killer cells prevents the development of immunosuppression after traumatic skeletal injury in mice. Clin Sci 128: 825-38. 

 

Neuhaus B, Frede A, Westendorf AM, Epple M. Gene silencing of the pro-inflammatory cytokine TNF-α with siRNA delivered by calcium phosphate nanoparticles, quantified by different methods. J. Mater. Chem. B, 2015,3, 7186-7193

 

Merches K, Khairnar V, Knuschke T,  Shaabani N, Honke N, Duhan V,  Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman H, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. Virus-Induced Type I Interferon Deteriotates Control of Systemic Pseudonomas Aeruginosa Infection. Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27.

 

Seiffart V, Zoeller J, Klopfleisch R, Wadwa M, Hansen W, Buer J, Riedel C, Westendorf AM. IL10-Deficiency in CD4 T Cells Exacerbates the IFNy and IL17 Response During Bacteria Induced Colitis. Cell Physiol Biochem. 2015 Jul 1;36(4):1259-1273.

 

Tatura R, Zeschnigk M, Hansen W, Steinmann J, Goncalves Vidigal P, Hutzler M, Pastille E,  Westendorf AM, Buer J, Kehrmann J. Relevance of Foxp3(+) regulatory T cells for early and late phases of murine sepsis. Immunology. 2015 Sep;146(1):144-56. doi: 10.1111/imm.12490. Epub 2015 Jul 2.

 

Sokolova V, Westendorf AM, Buer J, Überla K, Epple M. The potential of nanoparticles for the immunization against viral infections. J. Mater. Chem. B, 2015, DOI: 10.1039/C5TB00618J.

 

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217

 

Osswald A, Sun Z, Grimm V, Ampem G, Riegel K, Westendorf AM, Sommergruber W, Otte K, Dürre P and Riedel C.U. Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy. Microb Cell Fact. 2015 Dec 12;14 (1): 199

 

 

2014  

 

Langhorst J, Frede A,  Knott M, Pastille E, Buer J, Dobos GJ,  Westendorf AM. Distinct kindetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation of myrrh, chamomile, and coffee charcoal. PLoS One. 2014 Aug 21;9(8):e104257. doi: 10.1371

 

Schäfer ST, Gessner S, Scherag A, Rump K,  Frey UH, Siffert W, Westendorf AM,  Steinmann J, Peters J, Adamzik M. Hydrocortisone fails to abolish NF-&#954;B1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. PLoS One. 2014 Aug 18;9(8):e104953. doi: 10.1371

 

Jost NH,  Abel S, Hutzler M, Sparwasser T, Zimmermann  A, Roers A, Müller W, Kopfleisch R, Henge H, Westendorf AM,  Buer J, Hansen W. Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunology and Cell Biology. 29 Juli 2014; doi: 1038/icb.2014.62

 

Knuschke T,  Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W,  Dittmer U, Epple M, Buer J, Westendorf AM. Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protecitve immunity during acute and chronic retroviral infection. Nanomedicine. 2014 Jul 8. pii: S1549-9634(14)00327-X. doi: 10.1016/j.nano.2014.06.014.

 

Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M,  Sackaguchi S, Roers A,  Muller W, Hansen W, Buer J, Westendorf AM. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res. 2014 Jun 6. pii: canres.3065.2013.

 

Wirsdörfer F, Cappuccini F, Niazman M, de Leve S, Westendorf AM, Lüdemann L  Stuschke M, Jendrossek V. Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells. Radiat Oncol. 2014 Apr 25;9(1):98. doi: 10.1186/1748-717X-9-98.

 

Wirth T, Westendorf AM, Bloemker D, Wildmann J, Engler H,  Mollerus S,  Wadwa M, Schäfer MKH, Schedlowski M and del Rey A. The sympathetic nervous system modulates CD4+Foxp3+ regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease. Brain, Behavior, and Immunity. 2014 May;38:100-10. doi: 10.1016/j.bbi.2014.01.007.

 

Pastille E,  Pohlmann S, Wirsdörfer F, Reib A, Flohé AB. A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-&#947; production of NK cells in the lung during sepsis-induced immunosuppression. Innate Immun. 2014 Jan 9.

 

Kozlova D, Sokolova V, Zhong M, Zhang W, Yang J, L Wi, Yang Y, Buer J,  Westendorf AM,.Epple M, Yan H. Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin. Virol Sin. 2014 Feb; 29(1):33-9.

 

Knuschke T, Epple M and Westendorf AM. 2013. The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization. Hum. Vaccin. Immunother. 2014 Jan 1;10(1):164-9. doi: 10.4161/hv.26203. 

 

 

 

2013

 

Adamzik A, Broll J, Steinmann J, Westendorf AM, Rehfeld I, Kreissig C and  Peters J. 2013. An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality. Intensive Care Med. Aug. 2013.

 

Bruns S, Pastille E, Wirsdörfer F, Frisch M,  Flohé SB. 2013. Lipopeptides rather than lipopolysaccharide favor the development of dendritic cell dysfunction similar to polymicrobial sepsis in mice. Inflamm. Res. April 2013.

 

Knuschke T, Sokolova V, Rotan, Wadwa M, Tenbusch M, Hansen W,  Staeheli P, Epple M, Buer J and Westendorf AM. 2013. Immunization with Biodegradable Nanoparticles Efficiently Induces Cellular Immunity and Protects against Influenza Virus Infection. J. Immunol. May 10.

 

Westendorf AM 2013. Applications of nanoparticles for treating cutaneous infection. J Invest Dermatol. May;133(5):1133-5.

 

Sokolova V, Kozlova D, Knuschke T, Buer J, Westendorf AM, Epple M. 2013. Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells. Acta Biomater. Feb 26.

 

 

 

2012


Kozlova D, Chernousova S, Knuschke T,  Buer J, Westendorf AM, Epple M. 2012. Cell targeting by antibody-functionalized calcium phosphate nanoparticles. Journal of Materials Chemistry. 22, 396-404

 

Stecher B, Denzler R, Maier L, Bernet F, Sanders MJ, Derek J, Barthel M,  Krogfeld KA, Walker AW, Ackermann M, Westendorf AW, Dobrinth U, Thomson NR, Hardt WD. 2012. Gut inflammation can boost horizontal gene transfer between pathogenic and 3 commensal Enterobacteriace. Proc Natl Acad Sci U S A. Jan 24;109(4):1269-74.

 

Young GR, Ploquin MJ, Eksmond U, Wadwa M, Stoye JP,  Kassiotis G. 2012. Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathogen. May;8(5):e1002709

 

Abel S, Lückheide N, Westendorf AM, Geffers R, Roers A, Mueller W, Sparwasser T, Matuschewsk K, Buer J, Hansen W. 2012. Strong impact of CD4+Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. Journal of Immunology. Jun 1;188(11):5467-77.

 

Wild CA, Bergmann C, Fritz G, Schuler P, Hoffmann TK, Lofti R, Westendorf AM,  Brandau S, Lang S. 2012. HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. International Immunology. Aug;24(8):485-94.

 

Riß GL, Chang DI,  Wevers C, Westendorf AM, Buer J, Scherbaum N, Hansen W. 2012. Opioid maintenance therapy restores CD4+ T cell function by normalizing CD4+CD25high regulatory T cell frequencies in heroin addicts. Brain Behavior Immunology. Aug;26(6):972-8.

 

Sokolova V, Rotan O, Klesing J, Nalbant P, Buer J, Knuschke T, Westendorf AM,  Epple M. 2012. Calcium phosphate nanoparticles as versatile carrier for small and large molecules across cell membranes. Journal of Nanoparticle Research. (14) 910.

 

Hansen W, Hutzler M; Stockmann C, Kliche S, Albert J, Alter C, Westendorf AM, Schadendorf D, Buer J, Helfrich I. 2012. Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. Journal of Experimental Medicine. 209 2001-2016. 

 

 

2011

 

Fleissner D, Loser K, Hansen W, Dissemond J, Körber A, Beissert S, Buer J,  Westendorf AM. 2011. In vitro induced CD8+ regulatory T cells inhibit skin inflammation. European Journal of Microbiology and Immunology. Sept. 3, 208–214.

 

Sokolova V, Knuschke T, Buer J, Westendorf AM, Epple M. 2011. Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cells. Acta Biomaterialia. Nov;7(11):4029-36.

 

Fleissner D, Frede A, Knott M, Knuschke T, Geffers R, Hansen W, Dobos G,  Langhorst J, Buer J, Westendorf AM. 2011. Generation and function of immunosuppressive human and murine CD8(+) T cells by transforming growth factor-β and retinoic acid. Immunology. Sep;134(1):82-92

 

Ruhl M, Knuschke T, Schewior K, Glavinic L, Neumann-Haefelin C, Chang DI,  Klein M, Heinemann FM, Tenckhoff H, Wiese M, Horn PA,  Viazov S, Spengler U, Roggendorf M, Scherbaum N, Nattermann J, Hoffmann D, Timm J , East German HCV Study Group. 2011. CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins. Gastroenterology. Jun;140(7):2064-73

 

Schenk U, Frascoli M, Proietti M, BuerJ, Ricord C, Westendorf AM, Grassi F. 2011. ATP inhibits regulatory T cell function and generation through activation of P2X receptors. Science Signaling. Mar 1;4(162):ra12.

 

Pastille E, Didovic S, Braukmann D, Rani M, Agrawal H, Schade UU, Flohé SB. 2011. Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis. Journal of Immunology. Jan 15;186(2):977-86.

 

 

 

2010 

 

Fleissner D, Hansen W, Geffers R,  Buer J, Westendorf AM. 2010 Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues. PLoS ONE Oct 20;5(10):e15373.

 

Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C,  Hamann A, Huehn J. 2010. Retinoic acid-induced gut-tropism improves the protective capacity of regulatory T cells in acute-, but not in chronic gut inflammation. European Journal of Immunology. Sep;40(9):2539-48.

 

Sokolova V, Knuschke T, Kovtun A, Buer J, Epple M and Westendorf AM. 2010. The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation. Biomaterials. Gut 31: 5627-33.

 

Hansen W, Westendorf AM, Töpfer T, Mauel S, Geffers R, Gruber AD and Buer J. 2010. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. Genes Immun. 11: 357-61.

 

Westendorf AM, Fleissner D, Hansen W and Buer J. 2010. T cells, dendritic cells and epithelial cells in intestinal homeostasis. Int. J. Med. Microbiol. 300: 11-18.

 

 

2009

 

de Buhr M F, Hedrich HJ, Westendorf AM, Obermeier F, Hofmann C, Zschemisch NH, Buer J, Bumann D, Goyert SM and  Bleich A.2009. Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflamm. Bowel. Dis. 15: 1824-1836

 

Westendorf AM, Fleissner D, Groebe L, Jung S, Gruber AD, Hansen W and Buer J. 2009. CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. Gut 58: 211-219.

 

Bleich A, Janus LM, Smoczek A, Westendorf AM, Strauch U, Mahler M,  Hedrich HJ, Fichtner-Feigl S, Scholmerich J, Falk W, Hofmann C and  Obermeier F. 2009. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology 136: 278-287.

 

 

2008

 

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf AM, Buer,  Martin B, Wilhelm C, Stockinger B. 2008. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. Oct 19. 9: 1341-1346. 

 

Hansen W, Westendorf AM and Buer J. 2008. Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation. Inflamm. Allergy Drug Targets. 7: 217-223.

 

Schenk U,  Westendorf AM, Radaelli E, Casati M. Ferro, Fumagalli M, Verderio C,  Buer J, Scanziani E, Grassi F. 2008. Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels. Sci Signal. Sep 30;1(39):ra6.

 

Haile LA, von Wasielewski R, Gamrekelashvili J, Krüger C, Bachmann O,  Westendorf AM, Buer J,  Liblau R,  Manns MP, Korangy F,  Greten TJ. 2008. Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology. 135: 871-81, 881.

 

Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC and  Stockinger B. 2008. The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins. Nature 453:106.

 

Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J and Hansen W. 2008. CD83 expression in CD4+ T cells modulates inflammation and autoimmunity. Journal of. Immunology. 180:5890.

Saeedghalati M, Farahpour F, Budeus B, Lange A, Westendorf AM, Seifert M, Küppers R, Hoffmann D. Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes. PLoS Comput Biol. 2017 Jan 23;13(1):e1005362. doi: 10.1371/journal.pcbi.1005362.2016

 

 

2007

Stecher B, Robbiani R, Walker A, Westendorf AM, Barthel M, Kremer M, Chaffron S, Macpherson A, Buer J, Parkhill J, Dougan G, von Mering C, and Hardt W-D. (2007). Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biology. 5/e244: 1-13 

 

Hansen W, Westendorf AM, Reinwald S, Bruder D, Deppenmeier S, Groebe L, Probst-Kepper M., Gruber AD, Geffers R, Buer J (2007). Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3-CD25- regulatory T cells. Journal of Immunology 179: 8059-8068

 

Ukena SN, Hansen W, Bleich A, Bruder D, Rogler G, Suerbaum S., Buer J., Gunzer F., Westendorf A.M. (2007). Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal Integrity. PLoS ONE. Dec 12;2(12):e1308.

 

 

2006

Garbe AI, Vermerr B, Hillemann T, Gamrekekashvili J, von Wasielewski R, Greten FR, Westendorf AM, Buer J, Schmid RM, Manns MP, Korangy F, Greten TF (2006); Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Research 66: 508-516. 

 

de Buhr M, Mähler M, Geffers R, Hansen W, Westendorf AM, Lauber J, Buer J, Akira S, Schlegelberger B, Dedrich HJ, Bleich A. (2006). CD14, Gbp1, and Pla2g2a: 3 major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiological Genomics 16;25(3):426-34.

 

Hansen W, Loser K, Westendorf AM, Bruder D, Siewert C, Huehn J, Beissert S, Buer J. (2006). G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. Journal of Immunology 177(1):209-15

 

Westendorf AM, Fleissner D, Deppenmeier S, Gruber AD, Bruder D, Hansen W, Liblau R, Buer J. (2006). Autoimmune mediated intestinal inflammation – impact and regulation of antigen specific CD8+ T cells. Gastroenterology 131(2):510-24

 

Pfoertner S, Jeron A, Probst-Kepper M, Guzman CA, Hansen W, Westendorf AM, Toepfer T, Schrader AJ, Franzke A, Buer J, Geffers R (2006) Signatures of Human Regulatory T Cells: An Encounter with Old Friends and New Players. Genome Biology 7: R54.1-54.18.

 

Westendorf AM, Bruder D, Hansen W, Buer J.(2006). Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model. Annals of the New York Academy of Science 1072: 401–406

 

 

2005

Westendorf AM, Templin M, Geffers R, Deppenmeier S, Gruber AD, Probst-Kepper, M, Hansen W, Liblau RS, Gunzer F, Bruder D and Buer J. (2005). CD4+ T cell mediated intestinal immunity: chronic inflammation versus immune regulation. Gut. 54, 60-69 

 

Westendorf AM, Gunzer F, Deppenmmeier S, Tapadar D, Hunger K, Schmidt MA, Buer J, Bruder D (2005).  Intestinal immunity of E. coli NISSLE 1917: A safe carrier for therapeutic molecules.  FEMS Immunology and Medical Microbiology. 43. 373-384

 

Sun J, Gunzer F, Westendorf AM, Buer J, Scharfe M, Gößling F, Blöcker H, Zeng AP. (2005). Genomic preculiarity of coding sequences and metabolic potential of probiotic Escherichia coli strain Nissle 1917 inferred from raw genome data. Journal of Biotechnology. 4. 147-161

 

Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, Mahnke K, Buer J. (2005). On the edge of autoimmunity: T cells stimulation by steady state dendritic cells prevents autoimmune diabetes. Diabetes 54: 3395-3401. *contributed equally to this work

 

Buer J, Westendorf AM, Zeng AP, Hansen W, Probst-Kepper M. (2005). Mechanisms of central and peripheral T cell tolerance: An update. Transfusion Medicine and Hemotherapy. 32:384–399

 

Ukena SN, Westendorf AM, Hansen W, Rohde M, Geffers R, Coldewey S, Suerbaum S, Buer J, Gunzer F (2005). The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1. BMC Medical Genomics 13;6(1):43

 

 

2004

Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser, K., von Boehmer, H., Buer, J. and Hansen, W. (2004). Neuropilin-1 – a surface marker of regulatory T-cells. Eur. J. Immunol. 34, 623-630 

 

Bruder D, Westendorf AM, Geffers R, Gruber AD, Gereke M, Enelow RI and Buer J (2004). CD4 T Lymphocyte–mediated lung disease: steady state between pathological and tolerogenic immune reactions. Am. J. Respir. Crit Care Med. 170:1145.