Institutsgruppe I, Räume 7.005 - 7.008b
Prof. Dr. med. Elke Cario Telefon: +49-201-723-4527
Fax: +49-201-723-6858
E-Mail: elke.cario@uni-due.de
Labor: Homepage Telefon: +49-201-723-4364
Fax: +49-201-723-4669
Details zum Forschungsschwerpunkt
Förderung durch: Crohn's and Colitis Foundation of America (CCFA) und Deutsche Forschungsgemeinschaft (DFG)
Wissenschaftliche Mitarbeiter:
Beispielhafte Projekte der Arbeitsgruppe:
1) Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.
Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, and Cario E.
J Immunol. 2013 Jun 1;190(11):5676-88. doi: 10.4049/jimmunol.1201592
(PDF)
2) Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer.
Eyking A, Ey B, Rünzi M, Roig AI, Reis H, Schmid KW, Gerken G, Podolsky DK, and Cario E.
Gastroenterology. 2011 Dec;141(6):2154-65. doi: 10.1053/j.gastro.2011.08.043
(PDF)
3) TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury.
Ey B, Eyking A, Gerken G, Podolsky DK, and Cario E.
J Biol Chem. 2009 Aug;284(33):22332-43. doi: 10.1074/jbc.M901619200
(JBC link)
4) Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.
Podolsky DK, Gerken G, Eyking A, and Cario E.
Gastroenterology. 2009 Jul;137(1):209-20. doi: 10.1053/j.gastro.2009.03.007
(PDF)
5) Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.
Cario E, Gerken G, Podolsky DK.
Gastroenterology. 2007 Apr;132(4):1359-74. doi: 10.1053/j.gastro.2007.02.056
(PDF)
6) Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C.
Cario E, Gerken G, Podolsky DK.
Gastroenterology. 2004 Jul;127(1):224-38. doi: 10.1053/j.gastro.2004.04.015
(PDF)
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